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Chemical Compound Review

Anaprox     sodium2-(6-methoxynaphthalen- 2-yl)propanoate

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Disease relevance of NAPROXEN

  • Successful migraine prophylaxis with naproxen sodium [1].
  • Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study [2].
  • Also the premonitory symptoms and photophobia improved significantly on naproxen sodium and significantly less rescue analgesics were required [2].
  • When the test medications were taken within 2 h of onset of attack, naproxen sodium was statistically significantly more effective than the ergotamine combination in reducing the severity of headache pain, nausea, and lightheadedness [3].
  • Thirty-seven patients with chronic back pain were entered into a randomised, 3-way, double-blind, cross-over comparison of naproxen sodium 550 mg twice daily, diflunisal 500 mg twice daily, and placebo [4].

Psychiatry related information on NAPROXEN


High impact information on NAPROXEN


Chemical compound and disease context of NAPROXEN


Biological context of NAPROXEN


Anatomical context of NAPROXEN


Associations of NAPROXEN with other chemical compounds


Gene context of NAPROXEN


Analytical, diagnostic and therapeutic context of NAPROXEN


  1. Successful migraine prophylaxis with naproxen sodium. Welch, K.M., Ellis, D.J., Keenan, P.A. Neurology (1985) [Pubmed]
  2. Naproxen sodium in the treatment of migraine. Johnson, E.S., Ratcliffe, D.M., Wilkinson, M. Cephalalgia : an international journal of headache. (1985) [Pubmed]
  3. Acute migraine attack therapy: comparison of naproxen sodium and an ergotamine tartrate compound. Pradalier, A., Rancurel, G., Dordain, G., Verdure, L., Rascol, A., Dry, J. Cephalalgia : an international journal of headache. (1985) [Pubmed]
  4. Naproxen sodium, diflunisal, and placebo in the treatment of chronic back pain. Berry, H., Bloom, B., Hamilton, E.B., Swinson, D.R. Ann. Rheum. Dis. (1982) [Pubmed]
  5. Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals. Baldwin, A.C., Stevenson, S.W., Dudley, G.A. J. Gerontol. A Biol. Sci. Med. Sci. (2001) [Pubmed]
  6. The influence of anxiety and locus of control on adolescents' response to naproxen sodium for mild to moderate pain. DuRant, R.H., Jay, S., Jerath, R., Fink, S. Journal of adolescent health care : official publication of the Society for Adolescent Medicine. (1988) [Pubmed]
  7. Differential response by adolescents to naproxen sodium therapy for spasmodic and congestive dysmenorrhea. Jay, M.S., Durant, R.H., Shoffitt, T., Linder, C.W. Journal of adolescent health care : official publication of the Society for Adolescent Medicine. (1986) [Pubmed]
  8. Change in pain threshold by meperidine, naproxen sodium, and acetaminophen as determined by electric pulp testing. Carnes, P.L., Cook, B., Eleazer, P.D., Scheetz, J.P. Anesthesia progress. (1998) [Pubmed]
  9. Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly. Mamdani, M., Rochon, P., Juurlink, D.N., Anderson, G.M., Kopp, A., Naglie, G., Austin, P.C., Laupacis, A. Arch. Intern. Med. (2003) [Pubmed]
  10. Gastrointestinal tract bleeding associated with naproxen sodium vs ibuprofen. Strom, B.L., Schinnar, R., Bilker, W.B., Feldman, H., Farrar, J.T., Carson, J.L. Arch. Intern. Med. (1997) [Pubmed]
  11. Anirolac vs. naproxen for postpartum uterine pain. Bloomfield, S.S., Cissell, G.B., Peters, N.M., Mitchell, J., Nelson, E.D., Barden, T.P. Clin. Pharmacol. Ther. (1987) [Pubmed]
  12. Prostaglandin E2 content in residual gastric juice reflects endoscopic damage to the gastric mucosa after naproxen sodium administration. Sarosiek, J., Marcinkiewicz, M., Parolisi, S., Peura, D.A. Am. J. Gastroenterol. (1996) [Pubmed]
  13. Naproxen and naproxen sodium in acute migraine attacks. Nestvold, K. Cephalalgia : an international journal of headache. (1986) [Pubmed]
  14. Severe metabolic acidosis after acute naproxen sodium ingestion. Martinez, R., Smith, D.W., Frankel, L.R. Annals of emergency medicine. (1989) [Pubmed]
  15. Sumatriptan and naproxen sodium for the acute treatment of migraine. Smith, T.R., Sunshine, A., Stark, S.R., Littlefield, D.E., Spruill, S.E., Alexander, W.J. Headache. (2005) [Pubmed]
  16. Valdecoxib, a cyclooxygenase-2-specific inhibitor, is effective in treating primary dysmenorrhea. Daniels, S.E., Talwalker, S., Torri, S., Snabes, M.C., Recker, D.P., Verburg, K.M. Obstetrics and gynecology. (2002) [Pubmed]
  17. Myometrial oxytocin receptors and prostaglandin in the parturition process in the rat. Chan, W.Y., Chen, D.L. Biol. Reprod. (1992) [Pubmed]
  18. Pharmacokinetics of naproxen sodium. Moyer, S. Cephalalgia : an international journal of headache. (1986) [Pubmed]
  19. Effects of various granulating systems on the bioavailability of naproxen sodium from polymeric matrix tablets. Dahl, T., Ling, T., Yee, J., Bormeth, A. Journal of pharmaceutical sciences. (1990) [Pubmed]
  20. Control of menorrhagia by the cyclo-oxygenase inhibitors naproxen sodium and mefenamic acid. Hall, P., Maclachlan, N., Thorn, N., Nudd, M.W., Taylor, C.G., Garrioch, D.B. British journal of obstetrics and gynaecology. (1987) [Pubmed]
  21. A double-blind, randomized study of naproxen sodium, ibuprofen, and placebo in postoperative dental pain. Kiersch, T.A., Halladay, S.C., Koschik, M. Clinical therapeutics. (1993) [Pubmed]
  22. The effect of naproxen and interleukin-1 on proteoglycan catabolism and on neutral metalloproteinase activity in normal articular cartilage in vitro. Glazer, P.A., Rosenwasser, M.P., Ratcliffe, A. Journal of clinical pharmacology. (1993) [Pubmed]
  23. Naproxen kinetics in synovial fluid of patients with osteoarthritis. Bruno, R., Iliadis, A., Jullien, I., Guego, M., Pinhas, H., Cunci, S., Cano, J.P. British journal of clinical pharmacology. (1988) [Pubmed]
  24. Effects of inactivation of oxytocin receptor and inhibition of prostaglandin synthesis on uterine oxytocin receptor and gap junction formation and labor in the rat. Chan, W.Y., Berezin, I., Daniel, E.E., Russell, K.C., Hruby, V.J. Can. J. Physiol. Pharmacol. (1991) [Pubmed]
  25. Differential inhibition of fetal vascular prostacyclin and platelet thromboxane synthesis by nonsteroidal anti-inflammatory drugs in humans. Mäkilä, U.M., Kokkonen, E., Viinikka, L., Ylikorkala, O. Prostaglandins (1983) [Pubmed]
  26. The relationship between the content of aggressive and protective components in gastric juice and endoscopic findings after naproxen sodium and acetaminophen administration. Marcinkiewicz, M., Peura, D.A., Sarosiek, J. Am. J. Gastroenterol. (1996) [Pubmed]
  27. Comparison of the analgesic efficacy of rofecoxib and enteric-coated diclofenac sodium in the treatment of postoperative dental pain: a randomized, placebo-controlled clinical trial. Chang, D.J., Desjardins, P.J., Chen, E., Polis, A.B., McAvoy, M., Mockoviak, S.H., Geba, G.P. Clinical therapeutics. (2002) [Pubmed]
  28. Etoricoxib provides analgesic efficacy to patients after knee or hip replacement surgery: a randomized, double-blind, placebo-controlled study. Rasmussen, G.L., Malmstrom, K., Bourne, M.H., Jove, M., Rhondeau, S.M., Kotey, P., Ang, J., Aversano, M., Reicin, A.S. Anesth. Analg. (2005) [Pubmed]
  29. Correlation between drug release kinetics from proteineous matrix and matrix structure: EPR and NMR study. Katzhendler, I., Mäder, K., Friedman, M. Journal of pharmaceutical sciences. (2000) [Pubmed]
  30. Correlation between drug release kinetics from proteineous matrices and protein folding: elasticity and compressibility study. Katzhendler, I., Priev, A., Friedman1, M. Journal of controlled release : official journal of the Controlled Release Society. (2000) [Pubmed]
  31. A look at the safety profile of over-the-counter naproxen sodium: a meta-analysis. Bansal, V., Dex, T., Proskin, H., Garreffa, S. Journal of clinical pharmacology. (2001) [Pubmed]
  32. Comparative analgesic effects of naproxen sodium, aspirin, and placebo. Sevelius, H., Segre, E., Bursick, K. Journal of clinical pharmacology. (1980) [Pubmed]
  33. Naproxen sodium in uterine pain following intrauterine contraceptive device insertion. Buttram, V., Izu, A., Henzl, M.R. Am. J. Obstet. Gynecol. (1979) [Pubmed]
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