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MeSH Review

Nerve Fibers, Unmyelinated

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Disease relevance of Nerve Fibers, Unmyelinated


Psychiatry related information on Nerve Fibers, Unmyelinated

  • The destruction of C fibers by capsaicin was attenuated during development, but individual differences in the reduction of C fibers were observed on and after 15 days of life and seemed to become more marked over time [5].
  • It will be necessary to assess the inhibitory effect of capsaicin on DO caused by activation of C-fibers and the reversibility of C-fiber activation after surgical treatment for BPH, so that the criteria for decision-making for the treatment of BPH may be clarified with the aid of the IWT [6].

High impact information on Nerve Fibers, Unmyelinated


Chemical compound and disease context of Nerve Fibers, Unmyelinated


Biological context of Nerve Fibers, Unmyelinated


Anatomical context of Nerve Fibers, Unmyelinated


Associations of Nerve Fibers, Unmyelinated with chemical compounds

  • Electrically evoked nonadrenergic noncholinergic contractions of isolated bronchi mediated by the release of neurokinin A (NKA) from C-fibers, but not those elicited by exogenous NKA, were inhibited by NS1619 [25].
  • The mechanism may involve accumulation of prostaglandins, kinins (such as bradykinin), or substance P (neurotransmitter present in respiratory tract C-fibers); both bradykinin and substance P are degraded by ACE [26].
  • The decrease in binding results in the inability of galanin to inhibit the C fibers stimulation-induced facilitation of the rat flexor reflex, demonstrating that peptide-PNA constructs act in vivo to suppress expression of functional galanin receptors [27].
  • Sensitization of the foot withdrawal response after application of capsaicin (C fibers) or dimethyl sulfoxide (Adelta fibers) observed in control animals was reduced or eliminated in animals infected with the proenkephalin-encoding virus for at least 7 weeks postinfection [28].
  • Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog [29].

Gene context of Nerve Fibers, Unmyelinated

  • None of the C+ fibers immunostained for IgG or IgM, and none failed to immunostain for CD59 or CD46-inhibitors of the complement cascade [30].
  • Virtually all small neurons and C-fiber innervation requires TrkA to develop, but TrkC-reporter is present in only a small proportion that uniquely innervates piloneural complexes of guard hairs and inner conical bodies of vibrissa follicle-sinus complexes [31].
  • Neuropeptide Y (NPY) is a 36-amino-acid, C-terminal amidated peptide that is found in bulbospinal pathways and can inhibit the release of the primary afferent C-fiber neurotransmitter, substance P [32].
  • By immunohistochemistry, Ptc2 protein was seen on unmyelinated nerve fibers [33].
  • 2. In these preparations, various slow responses of spinal neurons evoked by stimulation of primary afferent C fibers were depressed by a tachykinin antagonist, spantide [34].

Analytical, diagnostic and therapeutic context of Nerve Fibers, Unmyelinated


  1. Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation. Chavolla-Calderón, M., Bayer, M.K., Fontán, J.J. J. Clin. Invest. (2003) [Pubmed]
  2. Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture. Garland, A., Jordan, J.E., Necheles, J., Alger, L.E., Scully, M.M., Miller, R.J., Ray, D.W., White, S.R., Solway, J. J. Clin. Invest. (1995) [Pubmed]
  3. Activation of dopamine D2-like receptors attenuates pulmonary C-fiber hypersensitivity in rats. Lin, Y.S., Gu, Q., Lee, L.Y. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  4. Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia. Sweitzer, S.M., Peters, M.C., Ma, J.Y., Kerr, I., Mangadu, R., Chakravarty, S., Dugar, S., Medicherla, S., Protter, A.A., Yeomans, D.C. Pain (2004) [Pubmed]
  5. Age-dependent attenuation of the decrease of C fibers by capsaicin and its effects on responses to nociceptive stimuli. Hiura, A., López Villalobos, E., Ishizuka, H. Somatosensory & motor research. (1992) [Pubmed]
  6. Positive response to ice water test associated with high-grade bladder outlet obstruction in patients with benign prostatic hyperplasia. Hirayama, A., Fujimoto, K., Matsumoto, Y., Ozono, S., Hirao, Y. Urology (2003) [Pubmed]
  7. Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Chen, S., Rio, C., Ji, R.R., Dikkes, P., Coggeshall, R.E., Woolf, C.J., Corfas, G. Nat. Neurosci. (2003) [Pubmed]
  8. Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. McLean, P.G., Ahluwalia, A., Perretti, M. J. Exp. Med. (2000) [Pubmed]
  9. Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibers. Kobayashi, K., Poo, M.M. Neuron (2004) [Pubmed]
  10. Hypotonicity induces TRPV4-mediated nociception in rat. Alessandri-Haber, N., Yeh, J.J., Boyd, A.E., Parada, C.A., Chen, X., Reichling, D.B., Levine, J.D. Neuron (2003) [Pubmed]
  11. Modulation of airway sensitivity to inhaled irritants: role of inflammatory mediators. Lee, L.Y., Widdicombe, J.G. Environ. Health Perspect. (2001) [Pubmed]
  12. Activation of C fibers by metabolic perturbations associated with tourniquet ischemia. MacIver, M.B., Tanelian, D.L. Anesthesiology (1992) [Pubmed]
  13. Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats. Yokoyama, O., Yusup, A., Miwa, Y., Oyama, N., Aoki, Y., Akino, H. J. Urol. (2005) [Pubmed]
  14. Effect of preemptive treatment of capsaicin or resiniferatoxin on the development of pre-micturition contractions after partial urethral obstruction in the rat. Tanaka, H., Kakizaki, H., Shibata, T., Mitsui, T., Koyanagi, T. J. Urol. (2003) [Pubmed]
  15. Prostanoids and cardiac reflexes of sympathetic and vagal origin. Staszewska-Barczak, J. Am. J. Cardiol. (1983) [Pubmed]
  16. Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy. Demiot, C., Tartas, M., Fromy, B., Abraham, P., Saumet, J.L., Sigaudo-Roussel, D. Diabetes (2006) [Pubmed]
  17. Effect of nedocromil sodium on neurogenic mechanisms in vitro. Myers, A.C., Riccio, M.M., Undem, B.J. J. Allergy Clin. Immunol. (1996) [Pubmed]
  18. Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis. Granovsky, Y., Matre, D., Sokolik, A., Lorenz, J., Casey, K.L. Pain (2005) [Pubmed]
  19. Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin. Tong, C., Conklin, D., Clyne, B.B., Stanislaus, J.D., Eisenach, J.C. Anesthesiology (2006) [Pubmed]
  20. Cigarette smoke-induced bronchoconstriction and release of tachykinins in guinea pig lungs. Lee, L.Y., Lou, Y.P., Hong, J.L., Lundberg, J.M. Respiration physiology. (1995) [Pubmed]
  21. Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Huettner, J.E. Neuron (1990) [Pubmed]
  22. Pharmacology of the effects of bradykinin, serotonin, and histamine on the release of calcitonin gene-related peptide from C-fiber terminals in the rat trachea. Hua, X.Y., Yaksh, T.L. J. Neurosci. (1993) [Pubmed]
  23. Negative feedback neuroendocrine control of the inflammatory response in rats. Green, P.G., Miao, F.J., Jänig, W., Levine, J.D. J. Neurosci. (1995) [Pubmed]
  24. The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn. Lever, I.J., Pezet, S., McMahon, S.B., Malcangio, M. Mol. Cell. Neurosci. (2003) [Pubmed]
  25. Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. Fox, A.J., Barnes, P.J., Venkatesan, P., Belvisi, M.G. J. Clin. Invest. (1997) [Pubmed]
  26. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Israili, Z.H., Hall, W.D. Ann. Intern. Med. (1992) [Pubmed]
  27. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Pooga, M., Soomets, U., Hällbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J.X., Xu, X.J., Wiesenfeld-Hallin, Z., Hökfelt, T., Bartfai, T., Langel, U. Nat. Biotechnol. (1998) [Pubmed]
  28. Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Wilson, S.P., Yeomans, D.C., Bender, M.A., Lu, Y., Goins, W.F., Glorioso, J.C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  29. Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog. Kaufman, M.P., Baker, D.G., Coleridge, H.M., Coleridge, J.C. Circ. Res. (1980) [Pubmed]
  30. Unexpected sarcolemmal complement membrane attack complex deposits on nonnecrotic muscle fibers in muscular dystrophies. Spuler, S., Engel, A.G. Neurology (1998) [Pubmed]
  31. TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. Fünfschilling, U., Ng, Y.G., Zang, K., Miyazaki, J., Reichardt, L.F., Rice, F.L. J. Comp. Neurol. (2004) [Pubmed]
  32. The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. Hua, X.Y., Boublik, J.H., Spicer, M.A., Rivier, J.E., Brown, M.R., Yaksh, T.L. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  33. Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. Bajestan, S.N., Umehara, F., Shirahama, Y., Itoh, K., Sharghi-Namini, S., Jessen, K.R., Mirsky, R., Osame, M. J. Neurobiol. (2006) [Pubmed]
  34. Pain and neurotransmitters. Otsuka, M., Yanagisawa, M. Cell. Mol. Neurobiol. (1990) [Pubmed]
  35. Interactions between sympathetic vasoconstrictor outflow and C nociceptor-induced antidromic vasodilatation. Ochoa, J.L., Yarnitsky, D., Marchettini, P., Dotson, R., Cline, M. Pain (1993) [Pubmed]
  36. Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular headache. Markowitz, S., Saito, K., Moskowitz, M.A. Cephalalgia : an international journal of headache. (1988) [Pubmed]
  37. Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats. Weng, H.R., Dougherty, P.M. Neuroscience (2005) [Pubmed]
  38. Sensory neuropeptide interactions in the production of plasma extravasation in the rat. Green, P.G., Basbaum, A.I., Levine, J.D. Neuroscience (1992) [Pubmed]
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