Disease relevance of Dicyclanil

• In addition, to investigate its possible initiation activity, partially hepatectomized male F344 rats given a single oral administration of 75 mg/kg body weight of dicyclanil were examined by a short-term liver initiation assay [1].

High impact information on Dicyclanil

• The insecticides spinosad, diazinon, nitenpyram, lufenuron and dicyclanil did not induce any P450, GST or esterase gene expression after a short exposure to high lethal concentrations of insecticide [2].
• Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice [3].
• Our previous studies showed the possibility that oxidative stress, including oxidative DNA damage, is involved in the mechanism of dicyclanil (DC)-induced hepatocarcinogenesis at the preneoplastic stage in mice [4].
• Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice [4].
• Three and 24 hr after administration, cell migration, as a marker of DNA damage in comet assay, was not observed in any of the tissues of dicyclanil-treated mice [1].

Analytical, diagnostic and therapeutic context of Dicyclanil

• Efficacy of dicyclanil in the prevention of screwworm infestation (Cochliomyia hominivorax) in cattle castration wounds [5].
• When compared with the control groups, dicyclanil achieved a 100 per cent reduction of infestation in the treated groups of both flocks for at least 24 weeks, and an 80 per cent reduction for 31 weeks [6].
• Sheep treated with dicyclanil reached the 1% limit at week 21 after treatment [7].

References