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Chemical Compound Review

Lufenuron     N-[[2,5-dichloro-4- (1,1,2,3,3,3...

Synonyms: Lufenurone, Fluphenacur, Lufenuronum, CHEMBL1364906, BSPBio_002424, ...
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Disease relevance of Lufenuron


High impact information on Lufenuron


Chemical compound and disease context of Lufenuron


Biological context of Lufenuron


Anatomical context of Lufenuron

  • The chorion of lufenuron-treated larvae consisted of an outer layer, middle and inner layers that were thinner and less electron dense than those of controls, and lacked the innermost chorionic layer found in the control larvae [15].
  • An unexpected result of lufenuron treatment was the inhibition of midgut epithelial cell differentiation [16].
  • Electron micrographs showed that lufenuron often disrupted formation of the endocuticle resulting in the deposition of an amorphous mass of randomly oriented chitin microfibrils [17].
  • Microscopic examination of unhatched larvae, revealed that the cuticle epidermal cells, chorion, and vitelline membrane all were affected by lufenuron treatment [15].
  • Dermatophyte cultures isolated from clinical cases were exposed to lufenuron by three different methods: direct application and application of whole blood or subcutaneous tissue samples obtained from a lufenuron-treated healthy dog [18].

Associations of Lufenuron with other chemical compounds


Gene context of Lufenuron

  • One exception was lufenuron, which caused no significant toxicity to the host cells and expressed approximate MIC50 values of 2.95 micrograms/ml and 6.3 micrograms/ml against E. intestinalis and V. corneae, respectively [24].

Analytical, diagnostic and therapeutic context of Lufenuron


  1. In vitro efficacy of lufenuron against filamentous fungi and blood concentrations after PO administration in horses. Scotty, N.C., Evans, T.J., Giuliano, E., Johnson, P.J., Rottinghaus, G.E., Fothergill, A.W., Cutler, T.J. J. Vet. Intern. Med. (2005) [Pubmed]
  2. Effects of lufenuron treatment in cats on the establishment and course of Microsporum canis infection following exposure to infected cats. DeBoer, D.J., Moriello, K.A., Blum, J.L., Volk, L.M. J. Am. Vet. Med. Assoc. (2003) [Pubmed]
  3. Action of major insecticide groups on insect cell lines of the beet armyworm, Spodoptera exigua, compared with larvicidal toxicity. Decombel, L., Smagghe, G., Tirry, L. In Vitro Cell. Dev. Biol. Anim. (2004) [Pubmed]
  4. Use of lufenuron as a treatment for fungal endometritis in four mares. Hess, M.B., Parker, N.A., Purswell, B.J., Dascanio, J.D. J. Am. Vet. Med. Assoc. (2002) [Pubmed]
  5. Lufenuron and tick paralysis. Strakosch, M.R. Aust. Vet. J. (2000) [Pubmed]
  6. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz, M.R., Chung, H., Magoc, L., Rigby, S., Wong, W., O'Keefe, M., McKenzie, J.A., Batterham, P., Daborn, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Determination of pesticide residues in coconut water by liquid-liquid extraction and gas chromatography with electron-capture plus thermionic specific detection and solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. Brito, N.M., Navickiene, S., Polese, L., Jardim, E.F., Abakerli, R.B., Ribeiro, M.L. Journal of chromatography. A. (2002) [Pubmed]
  8. A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital. Willoughby, L., Chung, H., Lumb, C., Robin, C., Batterham, P., Daborn, P.J. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  9. Efficacy of lufenuron against developmental stages of fleas (Ctenocephalides felis felis) in dogs housed in simulated home environments. Blagburn, B.L., Hendrix, C.M., Vaughan, J.L., Lindsay, D.S., Barnett, S.H. Am. J. Vet. Res. (1995) [Pubmed]
  10. Synergistic effect of entomogenous fungi on some insecticides against Bihar hairy caterpillar Spilarctia obliqua (Lepidoptera: Arctiidae). Purwar, J.P., Sachan, G.C. Microbiol. Res. (2006) [Pubmed]
  11. Evaluation of the susceptibility of Coccidioides immitis to lufenuron, a chitin synthase inhibitor. Johnson, S.M., Zimmermann, C.R., Kerekes, K.M., Davidson, A., Pappagianis, D. Med. Mycol. (1999) [Pubmed]
  12. Dose titration of an injectable formulation of lufenuron in cats experimentally infested with fleas. Blagburn, B.L., Vaughan, J.L., Butler, J.M., Parks, S.C. Am. J. Vet. Res. (1999) [Pubmed]
  13. Estimation of neonatal exposure after accidental ingestion of lufenuron in a breastfeeding mother. Bar-Oz, B., Ito, S., Parks, V., Maurer, M.P., Koren, G. Journal of human lactation : official journal of International Lactation Consultant Association. (2000) [Pubmed]
  14. Effects of lufenuron on Lobesia botrana (Lepidoptera: Tortricidae) egg, larval, and adult stages. Sáenz-de-Cabezón, F.J., Pérez-Moreno, I., Zalom, F.G., Marco, V. J. Econ. Entomol. (2006) [Pubmed]
  15. Effect of lufenuron on chorionic and cuticular structure of unhatched larval Ctenocephalides felis (Siphonaptera: Pulicidae). Meola, R.W., Dean, S.R., Meola, S.M., Sittertz-Bhatkar, H., Schenker, R. J. Med. Entomol. (1999) [Pubmed]
  16. Mode of action of lufenuron in adult Ctenocephalides felis (Siphonaptera: Pulicidae). Dean, S.R., Meola, R.W., Meola, S.M., Sittertz-Bhatkar, H., Schenker, R. J. Med. Entomol. (1999) [Pubmed]
  17. Mode of action of lufenuron on larval cat fleas (Siphonaptera: Pulicidae). Dean, S.R., Meola, R.W., Meola, S.M., Sittertz-Bhatkar, H., Schenker, R. J. Med. Entomol. (1998) [Pubmed]
  18. In vitro and in vivo Effects of Lufenuron on Dermatophytes Isolated from Cases of Canine and Feline Dermatophytoses*. Zur, G., Elad, D. J. Vet. Med. B Infect. Dis. Vet. Public Health (2006) [Pubmed]
  19. Comparison of flea control strategies using imidacloprid or lufenuron on cats in a controlled simulated home environment. Jacobs, D.E., Hutchinson, M.J., Fox, M.T., Krieger, K.J. Am. J. Vet. Res. (1997) [Pubmed]
  20. Comparison of susceptibility of fungal isolates to lufenuron and nikkomycin Z alone or in combination with itraconazole. Hector, R.F., Davidson, A.P., Johnson, S.M. Am. J. Vet. Res. (2005) [Pubmed]
  21. Disruption of reproductive activity of Coptotermes formosanus (Isoptera: Rhinotermitidae) primary reproductives by three chitin synthesis inhibitors. Rojas, M.G., Morales-Ramos, J.A. J. Econ. Entomol. (2004) [Pubmed]
  22. Resistance to the insecticides lufenuron and propoxur in natural populations of Drosophila melanogaster (Diptera: Drosophilidae). Wilson, T.G., Cain, J.W. J. Econ. Entomol. (1997) [Pubmed]
  23. Selectivity of pesticides used on cotton (Gossypium hirsutum) to Trichogramma pretiosum reared on two laboratory-reared hosts. Bastos, C.S., de Almeida, R.P., Suinaga, F.A. Pest Manag. Sci. (2006) [Pubmed]
  24. Screening of compounds for antimicrosporidial activity in vitro. Didier, E.S., Maddry, J.A., Kwong, C.D., Green, L.C., Snowden, K.F., Shadduck, J.A. Folia Parasitol. (1998) [Pubmed]
  25. Use of lufenuron for treating fungal infections of dogs and cats: 297 cases (1997-1999). Ben-Ziony, Y., Arzi, B. J. Am. Vet. Med. Assoc. (2000) [Pubmed]
  26. Use of injectable lufenuron for treatment of infestations of Ctenocephalides felis in cats. Franc, M., Cadiergues, M.C. Am. J. Vet. Res. (1997) [Pubmed]
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