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Chemical Compound Review

Triostin A     N-[3,11,13,16,24,26- hexamethyl-2,5,9,12,15...

Synonyms: NSC-244425, AC1L7TVE, NSC244425, NCI60_001953, B100928K382, ...
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High impact information on Triostin A


Biological context of Triostin A

  • The molecular conformations are compared with those deduced from NMR data and those reported for two complexes of triostin A with oligonucleotides [6].
  • In an effort to carry out anti-cancer drug design, we synthesized another novel cyclic peptide as the analogue of the cyclic peptide in Triostin A [7].

Anatomical context of Triostin A


Associations of Triostin A with other chemical compounds


Gene context of Triostin A

  • Normal-phase LC analysis of the n- and p-conformer interconversion of triostin A dissolved in chloroform results in a value of 0.04/s for kn-p at 25 degrees C, with a corresponding activation energy of 18 kcal/mol [11].


  1. Molecular mechanical studies of d(CGTACG)2: complex of triostin A with the middle A - T base pairs in either Hoogsteen or Watson-Crick pairing. Singh, U.C., Pattabiraman, N., Langridge, R., Kollman, P.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. NMR investigation of Hoogsteen base pairing in quinoxaline antibiotic--DNA complexes: comparison of 2:1 echinomycin, triostin A and [N-MeCys3,N-MeCys7] TANDEM complexes with DNA oligonucleotides. Addess, K.J., Feigon, J. Nucleic Acids Res. (1994) [Pubmed]
  3. DNA sequence recognition by under-methylated analogues of triostin A. Low, C.M., Fox, K.R., Olsen, R.K., Waring, M.J. Nucleic Acids Res. (1986) [Pubmed]
  4. DNA-ditercalinium interactions: implications for recognition of damaged DNA. Williams, L.D., Gao, Q. Biochemistry (1992) [Pubmed]
  5. Efficient solid-phase-based total synthesis of the bisintercalator TANDEM. Malkinson, J.P., Anim, M.K., Zloh, M., Searcey, M., Hampshire, A.J., Fox, K.R. J. Org. Chem. (2005) [Pubmed]
  6. Structures of quinoxaline antibiotics. Sheldrick, G.M., Heine, A., Schmidt-Bäse, K., Pohl, E., Jones, P.G., Paulus, E., Waring, M.J. Acta Crystallogr., B (1995) [Pubmed]
  7. A novel cyclic octapeptide as an analogue of cyclic peptide in triostin A. Yang, P., Song, Y. Prep. Biochem. Biotechnol. (2002) [Pubmed]
  8. Equilibrium and kinetic studies on the binding of des-N-tetramethyltriostin A to DNA. Fox, K.R., Olsen, R.K., Waring, M.J. Biochim. Biophys. Acta (1982) [Pubmed]
  9. DNA recognition by quinoxaline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of triostin A and TANDEM. Bailly, C., Waring, M.J. Biochem. J. (1998) [Pubmed]
  10. Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations. Marco, E., Negri, A., Luque, F.J., Gago, F. Nucleic Acids Res. (2005) [Pubmed]
  11. Conformer interconversion in the LC analysis of triostin A and its under-N-methylated synthetic analogue. Alfredson, T.V., Bruins, P.W., Maki, A.H., Excoffier, J.L. Journal of chromatographic science. (1994) [Pubmed]
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