Disease relevance of D02427

• Plasma insulin response to glibornuride in thyrotoxicosis [1].
• Peripheral uptake and hepatic production of glucose and lipolysis were measured during hyperinsulinemia using the euglycemic clamp technique and 3-3H-glucose infusions twice, once during a period with glibornuride treatment (50 mg b.i.d.), and once without [2].

High impact information on D02427

• Lack of effect of tenoxicam on glibornuride kinetics and response [3].
• The single i.v. dose of glibornuride had no detectable effect on the kinetics of tenoxicam [3].
• Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats [4].
• It was concluded that probably, due to its antioxidant property, parsley extract has a protective effect comparable to glibornuride against hepatotoxicity caused by diabetes [4].
• The acute effects of therapeutic doses of intravenous tolbutamide and glibornuride on the systolic time intervals (QS2c, LVETc, PEPc and PEP/LVET) were examined in 5 healthy volunteers [5].

Analytical, diagnostic and therapeutic context of D02427

• Glibornuride is an addition to the second-generation sulphonylureas, that has been shown in clinical trials to be effective and non-toxic [6].

References