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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hyperinsulinism


Psychiatry related information on Hyperinsulinism


High impact information on Hyperinsulinism


Chemical compound and disease context of Hyperinsulinism

  • In addition, the mean (+/- SEM) fasting plasma triglyceride levels in subjects with hyperinsulinemia were significantly higher (1.73 +/- 0.2 vs. 1.24 +/- 0.1 mmol per liter) and the plasma high-density lipoprotein cholesterol concentrations were lower (1.21 +/- 0.06 vs. 1.43 +/- 0.06 mmol per liter) than in subjects with normoinsulinemia [15].
  • Seven patients with excessive growth (Group A) had hyperinsulinism, normal IGF values, elevated basal prolactin levels, and a delayed thyrotropin response to thyrotropin-releasing hormone, which was compatible with hypothalamic lesions [16].
  • CONCLUSIONS--In NIDDM patients, high-carbohydrate diets compared with high-monounsaturated-fat diets caused persistent deterioration of glycemic control and accentuation of hyperinsulinemia, as well as increased plasma triglyceride and very-low-density lipoprotein cholesterol levels, which may not be desirable [17].
  • Hyperinsulinemia and uric acid clearance [18].
  • On the other hand, the 163-171 fragment did not cause any of several inflammation-associated metabolic changes inducible by the whole IL-1 beta molecule in vivo: hypoferremia, hypoglycemia, hyperinsulinemia, increase in circulating corticosterone, SAA and fibrinogen, decrease in hepatic drug-metabolizing enzymes [19].

Biological context of Hyperinsulinism


Anatomical context of Hyperinsulinism


Gene context of Hyperinsulinism


Analytical, diagnostic and therapeutic context of Hyperinsulinism


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  2. Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. Taylor, T.E., Molyneux, M.E., Wirima, J.J., Fletcher, K.A., Morris, K. N. Engl. J. Med. (1988) [Pubmed]
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  12. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Kulkarni, R.N., Holzenberger, M., Shih, D.Q., Ozcan, U., Stoffel, M., Magnuson, M.A., Kahn, C.R. Nat. Genet. (2002) [Pubmed]
  13. Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome. Collin, G.B., Marshall, J.D., Ikeda, A., So, W.V., Russell-Eggitt, I., Maffei, P., Beck, S., Boerkoel, C.F., Sicolo, N., Martin, M., Nishina, P.M., Naggert, J.K. Nat. Genet. (2002) [Pubmed]
  14. A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene. Bitner-Glindzicz, M., Lindley, K.J., Rutland, P., Blaydon, D., Smith, V.V., Milla, P.J., Hussain, K., Furth-Lavi, J., Cosgrove, K.E., Shepherd, R.M., Barnes, P.D., O'Brien, R.E., Farndon, P.A., Sowden, J., Liu, X.Z., Scanlan, M.J., Malcolm, S., Dunne, M.J., Aynsley-Green, A., Glaser, B. Nat. Genet. (2000) [Pubmed]
  15. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. Zavaroni, I., Bonora, E., Pagliara, M., Dall'Aglio, E., Luchetti, L., Buonanno, G., Bonati, P.A., Bergonzani, M., Gnudi, L., Passeri, M. N. Engl. J. Med. (1989) [Pubmed]
  16. Insulin-like growth factors I and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma. Bucher, H., Zapf, J., Torresani, T., Prader, A., Froesch, E.R., Illig, R. N. Engl. J. Med. (1983) [Pubmed]
  17. Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. Garg, A., Bantle, J.P., Henry, R.R., Coulston, A.M., Griver, K.A., Raatz, S.K., Brinkley, L., Chen, Y.D., Grundy, S.M., Huet, B.A. JAMA (1994) [Pubmed]
  18. Hyperinsulinemia and uric acid clearance. Gaut, Z.N. JAMA (1992) [Pubmed]
  19. In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1 beta. Boraschi, D., Nencioni, L., Villa, L., Censini, S., Bossù, P., Ghiara, P., Presentini, R., Perin, F., Frasca, D., Doria, G. J. Exp. Med. (1988) [Pubmed]
  20. Insulin resistance in essential hypertension. Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M.A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., Bevilacqua, S. N. Engl. J. Med. (1987) [Pubmed]
  21. Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. Glaser, B., Chiu, K.C., Anker, R., Nestorowicz, A., Landau, H., Ben-Bassat, H., Shlomai, Z., Kaiser, N., Thornton, P.S., Stanley, C.A. Nat. Genet. (1994) [Pubmed]
  22. Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism. Buchanan, T.A., Thawani, H., Kades, W., Modrall, J.G., Weaver, F.A., Laurel, C., Poppiti, R., Xiang, A., Hsueh, W. J. Clin. Invest. (1993) [Pubmed]
  23. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. Farooqi, I.S., Yeo, G.S., Keogh, J.M., Aminian, S., Jebb, S.A., Butler, G., Cheetham, T., O'Rahilly, S. J. Clin. Invest. (2000) [Pubmed]
  24. Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm. Lembo, G., Iaccarino, G., Vecchione, C., Barbato, E., Izzo, R., Fontana, D., Trimarco, B. J. Clin. Invest. (1997) [Pubmed]
  25. Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats. Wardzala, L.J., Hirshman, M., Pofcher, E., Horton, E.D., Mead, P.M., Cushman, S.W., Horton, E.S. J. Clin. Invest. (1985) [Pubmed]
  26. Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. Miyake, K., Ogawa, W., Matsumoto, M., Nakamura, T., Sakaue, H., Kasuga, M. J. Clin. Invest. (2002) [Pubmed]
  27. Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool. Kahn, B.B., Horton, E.S., Cushman, S.W. J. Clin. Invest. (1987) [Pubmed]
  28. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Warram, J.H., Martin, B.C., Krolewski, A.S., Soeldner, J.S., Kahn, C.R. Ann. Intern. Med. (1990) [Pubmed]
  29. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Bernal-Mizrachi, C., Weng, S., Feng, C., Finck, B.N., Knutsen, R.H., Leone, T.C., Coleman, T., Mecham, R.P., Kelly, D.P., Semenkovich, C.F. Nat. Med. (2003) [Pubmed]
  30. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Kido, Y., Hayashi, Y., Nakayama, K.I., White, M.F., Kasuga, M. Nat. Med. (2005) [Pubmed]
  31. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Sund, N.J., Vatamaniuk, M.Z., Casey, M., Ang, S.L., Magnuson, M.A., Stoffers, D.A., Matschinsky, F.M., Kaestner, K.H. Genes Dev. (2001) [Pubmed]
  32. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Shimomura, I., Matsuda, M., Hammer, R.E., Bashmakov, Y., Brown, M.S., Goldstein, J.L. Mol. Cell (2000) [Pubmed]
  33. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. Huopio, H., Reimann, F., Ashfield, R., Komulainen, J., Lenko, H.L., Rahier, J., Vauhkonen, I., Kere, J., Laakso, M., Ashcroft, F., Otonkoski, T. J. Clin. Invest. (2000) [Pubmed]
  34. Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity. Laine, H., Yki-Jarvinen, H., Kirvela, O., Tolvanen, T., Raitakari, M., Solin, O., Haaparanta, M., Knuuti, J., Nuutila, P. J. Clin. Invest. (1998) [Pubmed]
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  37. Impaired function of pancreatic islets from rats with portal hypertension resulting from cirrhosis and partial portal vein ligation. Gomis, R., Fernández-Alvarez, J., Pizcueta, P., Fernández, M., Casamitjana, R., Bosch, J., Rodés, J. Hepatology (1994) [Pubmed]
  38. A new case of abnormal insulinemia with diabetes. Reduced insulin values determined by radioreceptor assay. Iwamoto, Y., Sakura, H., Ishii, Y., Yamamoto, R., Kumakura, S., Sakamoto, Y., Matsuda, A., Kuzuya, T. Diabetes (1986) [Pubmed]
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