Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Papc-hcl N'-(4-ethylaminobutyl)-N-[4- (4...

Synonyms: CHEMBL551489, NCIMech_000262, AG-K-15999, ACMC-20ckc1, SL-11061, ...

Dolan, M.E. et al., Dorhout, B. et al., Basu, H.S. et al., Jeffers, L. et al., Eiseman, J.L. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SL-11061

Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines [1].
The polyamine analogue 1,19-bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4), 5 mg/kg i.p., was given twice daily on days 0-3 and 7-10 (cycle 1) to nude mice with human malignant gliomas (SF-767 and U-87 MG), lung adenocarcinoma (A549), and colon carcinomas (HCT116 and HT29) [2].
cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines [3].
Slowing proliferation in head and neck tumors: in vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas [4].
As BE-4-4-4-4 proceeds toward and undergoes clinical evaluation, the data and analytical method presented herein should prove useful in formulating a dose-escalation strategy and, possibly, evaluating toxicities encountered [5].

High impact information on SL-11061

The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment [2].
No demonstrable effect of BE-4-4-4-4 on single dose radiation survival was identified in any SCC cell line [4].
CONCLUSION: Similar to the findings in the cell-free system, the polyamine analog BE-4-4-4-4 inhibited nucleosome formation and, thereby, altered the expression of specific genes in a cellular system [6].
RESULTS: We observed a more than six fold increase in SV-40 late gene expression in cells pretreated with BE-4-4-4-4 for 18 h [6].
PURPOSE: The polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) depletes cellular polyamines and inhibits malignant cell growth [6].

Chemical compound and disease context of SL-11061

CONCLUSION: These results show the polyamine analogues BE-4-4-4-4, BE-3-3-3 and BE-3-7-3 to be effective inhibitors of prostate cancer cell growth in vitro and BE-4-4-4-4 to be an effective inhibitor of DU145 cells in vivo with minimal toxicity [7].
Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines [8].

Biological context of SL-11061

1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) was given to mice carrying the U-87 MG or A549 tumors on day 4 (cycle 1) and day 46 (cycle 2) in the maximal tolerated dose of 50 mg/kg for BCNU alone and 40 mg/kg for BCNU plus BE-4-4-4-4 [2].
The plasma pharmacokinetics of BE-4-4-4-4 were linear with dose [5].

Associations of SL-11061 with other chemical compounds

Simultaneous determination of polyamines, N-acetylated polyamines and the polyamine analogues BE-3-3-3 and BE-4-4-4-4 by capillary gas chromatography with nitrogen-phosphorus detection [9].

Gene context of SL-11061

In vivo, mice were given saline or BE-4-4-4-4 3 mg/kg or 5 mg/kg intraperitoneally twice daily on days 7-10 and 14-17 (cycle 1), days 49-52 and 56-59 (cycle 2) and days 91-94 and 98-101 (cycle 3) [7].
RESULTS: BE-4-4-4-4 inhibited ornithine decarboxylase activity and depleted all 3 polyamines [10].

Analytical, diagnostic and therapeutic context of SL-11061

Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts [2].
There was significant inhibition of tumor growth after treatment with one cycle of BE-4-4-4-4 in animals carrying the A549, HCT116, and HT29 tumors [2].
The mitotic index of A549 tumors was 18 times greater in control mice than in those treated with BE-4-4-4-4 for one or two cycles 99 days after initiation of treatment [2].

References

Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines. Basu, H.S., Pellarin, M., Feuerstein, B.G., Shirahata, A., Samejima, K., Deen, D.F., Marton, L.J. Cancer Res. (1993) [Pubmed]
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. Dolan, M.E., Fleig, M.J., Feuerstein, B.G., Basu, H.S., Luk, G.D., Casero, R.A., Marton, L.J. Cancer Res. (1994) [Pubmed]
cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines. Reddy, V.K., Sarkar, A., Valasinas, A., Marton, L.J., Basu, H.S., Frydman, B. J. Med. Chem. (2001) [Pubmed]
Slowing proliferation in head and neck tumors: in vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas. Harari, P.M., Pickart, M.A., Contreras, L., Petereit, D.G., Basu, H.S., Marton, L.J. Int. J. Radiat. Oncol. Biol. Phys. (1995) [Pubmed]
Plasma pharmacokinetics and urinary excretion of the polyamine analogue 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane in CD2F1 mice. Eiseman, J.L., Yuan, Z.M., Eddington, N.D., Sentz, D.L., Callery, P.S., Egorin, M.J. Cancer Chemother. Pharmacol. (1996) [Pubmed]
Polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) enhances simian virus 40 late gene expression. Basu, H.S., Dreckschmidt, N., Tu, L., Chanbusarakum, L. Cancer Chemother. Pharmacol. (1999) [Pubmed]
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines. Jeffers, L., Church, D., Basu, H., Marton, L., Wilding, G. Cancer Chemother. Pharmacol. (1997) [Pubmed]
Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines. Bergeron, C.J., Basu, H.S., Marton, L.J., Deen, D.F., Pellarin, M., Feuerstein, B.G. Cancer Chemother. Pharmacol. (1995) [Pubmed]
Simultaneous determination of polyamines, N-acetylated polyamines and the polyamine analogues BE-3-3-3 and BE-4-4-4-4 by capillary gas chromatography with nitrogen-phosphorus detection. Dorhout, B., Kingma, A.W., de Hoog, E., Muskiet, F.A. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
A novel cytotoxic agent for human carcinoid tumors. Litvak, D.A., Papaconstantinou, H.T., Ko, T.C., Townsend, C.M. Surgery (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.