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Chemical Compound Review

Papc-hcl     N'-(4-ethylaminobutyl)-N-[4- (4...

Synonyms: CHEMBL551489, NCIMech_000262, AG-K-15999, ACMC-20ckc1, SL-11061, ...
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Disease relevance of SL-11061


High impact information on SL-11061

  • The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment [2].
  • No demonstrable effect of BE-4-4-4-4 on single dose radiation survival was identified in any SCC cell line [4].
  • CONCLUSION: Similar to the findings in the cell-free system, the polyamine analog BE-4-4-4-4 inhibited nucleosome formation and, thereby, altered the expression of specific genes in a cellular system [6].
  • RESULTS: We observed a more than six fold increase in SV-40 late gene expression in cells pretreated with BE-4-4-4-4 for 18 h [6].
  • PURPOSE: The polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) depletes cellular polyamines and inhibits malignant cell growth [6].

Chemical compound and disease context of SL-11061


Biological context of SL-11061


Associations of SL-11061 with other chemical compounds


Gene context of SL-11061

  • In vivo, mice were given saline or BE-4-4-4-4 3 mg/kg or 5 mg/kg intraperitoneally twice daily on days 7-10 and 14-17 (cycle 1), days 49-52 and 56-59 (cycle 2) and days 91-94 and 98-101 (cycle 3) [7].
  • RESULTS: BE-4-4-4-4 inhibited ornithine decarboxylase activity and depleted all 3 polyamines [10].

Analytical, diagnostic and therapeutic context of SL-11061


  1. Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines. Basu, H.S., Pellarin, M., Feuerstein, B.G., Shirahata, A., Samejima, K., Deen, D.F., Marton, L.J. Cancer Res. (1993) [Pubmed]
  2. Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. Dolan, M.E., Fleig, M.J., Feuerstein, B.G., Basu, H.S., Luk, G.D., Casero, R.A., Marton, L.J. Cancer Res. (1994) [Pubmed]
  3. cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines. Reddy, V.K., Sarkar, A., Valasinas, A., Marton, L.J., Basu, H.S., Frydman, B. J. Med. Chem. (2001) [Pubmed]
  4. Slowing proliferation in head and neck tumors: in vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas. Harari, P.M., Pickart, M.A., Contreras, L., Petereit, D.G., Basu, H.S., Marton, L.J. Int. J. Radiat. Oncol. Biol. Phys. (1995) [Pubmed]
  5. Plasma pharmacokinetics and urinary excretion of the polyamine analogue 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane in CD2F1 mice. Eiseman, J.L., Yuan, Z.M., Eddington, N.D., Sentz, D.L., Callery, P.S., Egorin, M.J. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  6. Polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) enhances simian virus 40 late gene expression. Basu, H.S., Dreckschmidt, N., Tu, L., Chanbusarakum, L. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  7. Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines. Jeffers, L., Church, D., Basu, H., Marton, L., Wilding, G. Cancer Chemother. Pharmacol. (1997) [Pubmed]
  8. Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines. Bergeron, C.J., Basu, H.S., Marton, L.J., Deen, D.F., Pellarin, M., Feuerstein, B.G. Cancer Chemother. Pharmacol. (1995) [Pubmed]
  9. Simultaneous determination of polyamines, N-acetylated polyamines and the polyamine analogues BE-3-3-3 and BE-4-4-4-4 by capillary gas chromatography with nitrogen-phosphorus detection. Dorhout, B., Kingma, A.W., de Hoog, E., Muskiet, F.A. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  10. A novel cytotoxic agent for human carcinoid tumors. Litvak, D.A., Papaconstantinou, H.T., Ko, T.C., Townsend, C.M. Surgery (1998) [Pubmed]
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