Chemical Compound Review:
Nitrumon 1,3-bis(2-chloroethyl)-1- nitroso-urea
Synonyms:
Becenum, Becenun, Carmubris, carmustine, BiCNU, ...
- Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors. Aronin, P.A., Mahaley, M.S., Rudnick, S.A., Dudka, L., Donohue, J.F., Selker, R.G., Moore, P. N. Engl. J. Med. (1980)
- Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood. O'Driscoll, B.R., Hasleton, P.S., Taylor, P.M., Poulter, L.W., Gattameneni, H.R., Woodcock, A.A. N. Engl. J. Med. (1990)
- Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Quinn, J.A., Jiang, S.X., Carter, J., Reardon, D.A., Desjardins, A., Vredenburgh, J.J., Rich, J.N., Gururangan, S., Friedman, A.H., Bigner, D.D., Sampson, J.H., McLendon, R.E., Herndon, J.E., Threatt, S., Friedman, H.S. Clin. Cancer Res. (2009)
- Intensive 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma. Phillips, G.L., Wolff, S.N., Fay, J.W., Herzig, R.H., Lazarus, H.M., Schold, C., Herzig, G.P. J. Clin. Oncol. (1986)
- Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity. Powell, S.R., Puglia, C.D. J. Pharmacol. Exp. Ther. (1987)
- Phase II study--intra-arterial BCNU therapy for metastatic brain tumors. Madajewicz, S., West, C.R., Park, H.C., Ghoorah, J., Avellanosa, A.M., Takita, H., Karakousis, C., Vincent, R., Caracandas, J., Jennings, E. Cancer (1981)
- The role of interstitial BCNU chemotherapy in the treatment of malignant glioma. Engelhard, H.H. Surgical neurology. (2000)
- Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. Esteller, M., Garcia-Foncillas, J., Andion, E., Goodman, S.N., Hidalgo, O.F., Vanaclocha, V., Baylin, S.B., Herman, J.G. N. Engl. J. Med. (2000)
- Carmustine as a cause of acute nonlymphocytic leukemia. Greene, M.H., Boice, J.D., Strike, T.A. N. Engl. J. Med. (1985)
- Vitamin E reversal of the effect of extracellular calcium on chemically induced toxicity in hepatocytes. Fariss, M.W., Pascoe, G.A., Reed, D.J. Science (1985)
- Effect of cell-cell interactions on drug sensitivity and growth of drug-sensitive and -resistant tumor cells in spheroids. Tofilon, P.J., Buckley, N., Deen, D.F. Science (1984)
- Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. Shen, J., Wenger, N., Glaspy, J., Hays, R.D., Albert, P.S., Choi, C., Shekelle, P.G. JAMA (2000)
- High-dose tri-alkylator chemotherapy with autologous stem cell rescue in patients with refractory malignancies. Moormeier, J.A., Williams, S.F., Kaminer, L.S., Garner, M., Bitran, J.D. J. Natl. Cancer Inst. (1990)
- Acute lung injury following treatment with high-dose cyclophosphamide, cisplatin, and carmustine: pharmacodynamic evaluation of carmustine. Jones, R.B., Matthes, S., Shpall, E.J., Fisher, J.H., Stemmer, S.M., Dufton, C., Stephens, J.K., Bearman, S.I. J. Natl. Cancer Inst. (1993)
- Modified chemotherapy with carmustine, cytarabine, cyclophosphamide, and 6-thioguanine (BACT) and autologous bone marrow transplantation in 24 poor-risk patients with acute lymphoblastic leukemia. Pico, J.L., Hartmann, O., Maraninchi, D., Beaujean, F., Benhamou, E., Mascret, B., Novakovitch, G., Ghalie, R., Kalifa, C., Hayat, M. J. Natl. Cancer Inst. (1986)
- Gastric cancer: current status of treatment. Carter, S.K., Comis, R.L. J. Natl. Cancer Inst. (1977)
- Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model. Eder, J.P., Teicher, B.A., Holden, S.A., Cathcart, K.N., Schnipper, L.E. J. Clin. Invest. (1987)
- Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. Micetich, K.C., Futscher, B., Koch, D., Fisher, R.I., Erickson, L.C. J. Natl. Cancer Inst. (1992)
- Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. Chenevert, T.L., Stegman, L.D., Taylor, J.M., Robertson, P.L., Greenberg, H.S., Rehemtulla, A., Ross, B.D. J. Natl. Cancer Inst. (2000)
- In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. Zielske, S.P., Reese, J.S., Lingas, K.T., Donze, J.R., Gerson, S.L. J. Clin. Invest. (2003)
- Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. Engelward, B.P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., Samson, L. EMBO J. (1996)
- Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. Durand, R.E. J. Natl. Cancer Inst. (1986)
- Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. Friedman, H.S., Dolan, M.E., Moschel, R.C., Pegg, A.E., Felker, G.M., Rich, J., Bigner, D.D., Schold, S.C. J. Natl. Cancer Inst. (1992)
- Sensitivity of proliferating cultured murine pancreatic tumor cells to selected antitumor agents. Wilkoff, L.J., Dulmadge, E.A. J. Natl. Cancer Inst. (1986)
- The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Chakravarti, A., Chakladar, A., Delaney, M.A., Latham, D.E., Loeffler, J.S. Cancer Res. (2002)
- Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Liu, L., Markowitz, S., Gerson, S.L. Cancer Res. (1996)
- Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes. Starke, P.E., Farber, J.L. J. Biol. Chem. (1985)
- Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. Yan, L., Donze, J.R., Liu, L. Oncogene (2005)
- Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors. Zaboikin, M., Srinivasakumar, N., Zaboikina, T., Schuening, F. Hum. Gene Ther. (2004)
- Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. Walker, M.D., Green, S.B., Byar, D.P., Alexander, E., Batzdorf, U., Brooks, W.H., Hunt, W.E., MacCarty, C.S., Mahaley, M.S., Mealey, J., Owens, G., Ransohoff, J., Robertson, J.T., Shapiro, W.R., Smith, K.R., Wilson, C.B., Strike, T.A. N. Engl. J. Med. (1980)
- Growth and rejection of leukemia cells in individual mice after combined treatment with amphotericin B and 1,3-bis(2-chloroethyl)-1-nitrosourea. Valeriote, F., Lynch, R., Medoff, G., Tolen, S., Dieckman, J. J. Natl. Cancer Inst. (1978)