Disease relevance of mefruside

• Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension [1].

High impact information on mefruside

• The increase in the slope was greater in patients whose slope had been depressed and blood pressure was sodium sensitive before mefruside treatment [2].
• Combined therapy with mefruside did not further reduce heart rate [1].
• 5-Oxo-mefruside was able to displace mefruside from its red blood cell binding sites in vitro [3].
• In this multicentre, randomised, double-blind, cross-over study, we evaluated and compared the effects of nitrendipine (a calcium entry blocker of the dihydropyridine group) and mefruside (a diuretic) on BP, cardiac output, cerebral blood flow and metabolic parameters in 22 elderly hypertensives [4].
• Pharmacokinetics of mefruside and two active metabolites in man [5].

Chemical compound and disease context of mefruside

• The long-term haemodynamic effects of treatment with mefruside alone or in combination with alprenolol have been studied in nine patients with essential hypertension [6].

Biological context of mefruside

• Quantitative gas chromatographic determination of mefruside in body fluids by extractive methylation and nitrogen detection [7].
• Comparison of nifedipine (retard formulation) and mefruside in the treatment of mild to moderate hypertension--a prospective randomized double-blind crossover study in general practice [8].

Anatomical context of mefruside

• Quantitative gas chromatographic determination of two oxidized metabolites of the diuretic mefruside in human urine, plasma and red blood cells [3].

Associations of mefruside with other chemical compounds

• The results of blood pressure measurements and laboratory investigations during the three phases of the study showed that significantly better blood pressure control was achieved with nifedipine alone than with mefruside alone [9].
• Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters [4].
• Dosages of mefruside and cyclopenthiazide were adjusted to give approximately equal blood pressure levels in the two drug periods [10].
• The additive hypotensive effect of alprenolol seems to be related in part to blocking of the increase in sympathetic activity that was found after treatment with mefruside alone [6].
• Blood pressure reduction and vascular adaptation. A study on long-term effects of treatment with mefruside or atenolol [11].

Analytical, diagnostic and therapeutic context of mefruside

• Determination of mefruside and its metabolites in urine by high performance liquid chromatography [12].
• The gas-liquid chromatographic method (GLC) was based on using cross-linked methylsilicone gum capillary column with flame ionization detector for the determination of nifedipine and mefruside in the binary mixture [13].
• Simultaneous determination of the binary mixture of nifedipine and mefruside using derivate spectroscopy, capillary gas-liquid chromatography and high performance liquid chromatography [13].
• Muscle content of water and electrolytes (needle biopsy), intraarterial BP and cardiac output (dye dilution technique) were measured in 12 patients with essential hypertension before and after 4 months of mefruside therapy (25 mg/day) [14].

References