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Chemical Compound Review

Baypress     ethyl methyl 2,6-dimethyl-4-(3...

Synonyms: Gericin, Jutapress, Niprina, Nitrensal, Trendinol, ...
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Disease relevance of Bayotensin


Psychiatry related information on Bayotensin


High impact information on Bayotensin


Chemical compound and disease context of Bayotensin


Biological context of Bayotensin

  • Nitrendipine was increased to 20 mg twice daily if the target diastolic blood pressure (<90 mm Hg) was not achieved [14].
  • 1 mM La3+, 10 mM Co2+, 50 microM verapamil, and 50 microM nitrendipine (calcium channel antagonists) reversibly inhibited lamellipod formation and cell locomotion in both spontaneously migrating and electrically guided cells [21].
  • Nitrendipine reduced systolic and diastolic pressures from 145 +/- 4/95 +/- 3 to 119 +/- 3/78 +/- 2 mm Hg, respectively, (p less than 0.001) through a fall in total peripheral resistance index (46 +/- 4 to 34 +/- 3 units/m2, p less than 0.001) without associated reflex cardiac stimulation [22].
  • When cells were held at depolarized membrane potentials at which Ca2+ currents were approximately equal to 70% inactivated, nitrendipine blocked Ca2+ currents very potently, with half-block by subnanomolar concentrations [23].
  • Nitrendipine treatment did not influence left ventricular mass (which was positively correlated with delta BW; p less than 0.01) but was associated with an increase in the left ventricular ejection fraction [3].

Anatomical context of Bayotensin


Associations of Bayotensin with other chemical compounds


Gene context of Bayotensin


Analytical, diagnostic and therapeutic context of Bayotensin

  • Blood pressure, echocardiography, and aortic and peripheral arterial pulse-wave velocity were studied in 40 hypertensive patients on long-term hemodialysis during a 24-week administration of nitrendipine (1,4-dihydro-2,6-dimethyl-4-[m-nitrophenyl]-3,5-pyridine-dicarboxylic acid ethyl methylester) monotherapy [3].
  • Pharmacological dissection of whole-cell barium currents revealed that 23% of the current was sensitive to nitrendipine, 35% to omega-conotoxin GVIA, and between 10 and 39% to omega-Aga-IVA [35].
  • Chronic denervation produces a further increase in the number of nitrendipine receptors which reaches a factor of about 2 at 15 days of denervation [36].
  • Data show that long-term calcium entry blockade by nitrendipine does not modify RBF or GFR despite the decreased renal perfusion pressure [37].
  • Heart rate and ejection fraction were similar in both control groups and hypertensive patients before and after nitrendipine [38].


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  15. Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons. Tolkovsky, A.M., Walker, A.E., Murrell, R.D., Suidan, H.S. J. Cell Biol. (1990) [Pubmed]
  16. Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group. Wang, J.G., Staessen, J.A., Gong, L., Liu, L. Arch. Intern. Med. (2000) [Pubmed]
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  18. Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium. Henry, P.D., Wahl, A.M. Eur. Heart J. (1983) [Pubmed]
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  20. Hemodynamic and metabolic effects of the calcium channel blocking agent nitrendipine. Johnson, B.F., Romero, L., Marwaha, R. Clin. Pharmacol. Ther. (1986) [Pubmed]
  21. Motility of cultured fish epidermal cells in the presence and absence of direct current electric fields. Cooper, M.S., Schliwa, M. J. Cell Biol. (1986) [Pubmed]
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  23. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Bean, B.P. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  24. Identification of two calcium channel receptor sites for [3H]nitrendipine in mammalian cardiac and smooth muscle membrane. Rogart, R.B., deBruyn Kops, A., Dzau, V.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids. Hallaq, H., Smith, T.W., Leaf, A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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  29. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Forette, F., Seux, M.L., Staessen, J.A., Thijs, L., Birkenhäger, W.H., Babarskiene, M.R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., Laks, T., Lilov, E., Moisseyev, V., Tuomilehto, J., Vanhanen, H., Webster, J., Yodfat, Y., Fagard, R. Lancet (1998) [Pubmed]
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  33. Neuropeptide-Y enhances luteinizing hormone (LH)-releasing hormone-induced LH release and elevations in cytosolic Ca2+ in rat anterior pituitary cells: evidence for involvement of extracellular Ca2+ influx through voltage-sensitive channels. Crowley, W.R., Shah, G.V., Carroll, B.L., Kennedy, D., Dockter, M.E., Kalra, S.P. Endocrinology (1990) [Pubmed]
  34. Effect of ageing in the early biochemical signals elicited by PTH in intestinal cells. Gentili, C., Picotto, G., Morelli, S., Boland, R., de Boland, A.R. Biochim. Biophys. Acta (2003) [Pubmed]
  35. Lambert-Eaton myasthenic syndrome immunoglobulins react with multiple types of calcium channels in small-cell lung carcinoma. Meriney, S.D., Hulsizer, S.C., Lennon, V.A., Grinnell, A.D. Ann. Neurol. (1996) [Pubmed]
  36. The nitrendipine-sensitive Ca2+ channel in chick muscle cells and its appearance during myogenesis in vitro and in vivo. Schmid, A., Renaud, J.F., Fosset, M., Meaux, J.P., Lazdunski, M. J. Biol. Chem. (1984) [Pubmed]
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