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Gene Review

IPK1  -  inositol pentakisphosphate 2-kinase

Saccharomyces cerevisiae S288c

Synonyms: GSL1, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Inositol-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase, ...
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High impact information on IPK1


Biological context of IPK1


Associations of IPK1 with chemical compounds

  • IP(3) accumulation upon glucose addition was completely absent in the plc1Delta strain and was amplified both by deletion of either ARG82 or IPK1 genes and by overexpression of PLC1 [8].
  • The ability to modulate the intracellular inositol polyphosphate levels by altering IPK2 and IPK1 expression in rat cells will provide powerful tools to study the roles of I(1,3,4,5,6)P5 and IP6 in cell signaling [1].

Analytical, diagnostic and therapeutic context of IPK1


  1. A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. Fujii, M., York, J.D. J. Biol. Chem. (2005) [Pubmed]
  2. Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway. Miller, A.L., Suntharalingam, M., Johnson, S.L., Audhya, A., Emr, S.D., Wente, S.R. J. Biol. Chem. (2004) [Pubmed]
  3. The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Verbsky, J.W., Wilson, M.P., Kisseleva, M.V., Majerus, P.W., Wente, S.R. J. Biol. Chem. (2002) [Pubmed]
  4. Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. Stevenson-Paulik, J., Odom, A.R., York, J.D. J. Biol. Chem. (2002) [Pubmed]
  5. Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. Ives, E.B., Nichols, J., Wente, S.R., York, J.D. J. Biol. Chem. (2000) [Pubmed]
  6. Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast. Perera, N.M., Michell, R.H., Dove, S.K. J. Biol. Chem. (2004) [Pubmed]
  7. Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis. Mio, T., Adachi-Shimizu, M., Tachibana, Y., Tabuchi, H., Inoue, S.B., Yabe, T., Yamada-Okabe, T., Arisawa, M., Watanabe, T., Yamada-Okabe, H. J. Bacteriol. (1997) [Pubmed]
  8. Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast. Tisi, R., Belotti, F., Wera, S., Winderickx, J., Thevelein, J.M., Martegani, E. Curr. Genet. (2004) [Pubmed]
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