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Chemical Compound Review

Quinine     (S)-[(4R,5S,7S)-5-ethenyl-1...

Synonyms: SureCN41279, SureCN6359943, CHEBI:15854, CCG-205108, AC1L9AHT, ...
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Disease relevance of Quinine

  • This article describes the results of a combined photophysical and photobiological study aimed at understanding the phototoxicity mechanism of the antimalarial drugs quinine (Q), quinacrine (QC) and mefloquine (MQ) [1].

Psychiatry related information on Quinine


High impact information on Quinine

  • We also observed associations between an ABC transporter (G7) and response to QN and AS and between another ABC transporter (G49) and response to dihydro-artemisinin (DHA) [3].
  • Second, quinine (Q), tetraethylammonium ion (TEA) and charybdotoxin (CTX), at concentrations not affecting cell viability, all decreased 3H-TdR incorporation and cell growth in PC.RC cultures, but only TEA had similar effects in transformed cells [4].
  • Pharmacokinetics of (+)-M1, but not (+)-T, was affected by Q pretreatment: early after the start of (+)-T infusion, levels of (+)-M1 were significantly lower (P < 0.05) [5].
  • The results obtained showed that fluorescence and intersystem crossing account for all the adsorbed quanta for Q and MQ (quantum yield of about 0.1 and 0.9, respectively) and only for 24% in the case of QC, which has a negligible fluorescence quantum yield (0.001) [1].
  • The speed and stage specificity of antimalarial drug action on the metabolic activities of cultured Plasmodium falciparum were studied for chloroquine (CQ), quinine (QN), artemisinin (AR), and sodium artelinate (SA) [6].

Biological context of Quinine

  • For QN and MQ, the median IC50 values showed no significant difference related to clinical status, age or parasitaemia levels [7].

Anatomical context of Quinine

  • The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action [8].

Associations of Quinine with other chemical compounds


  1. Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions. Aloisi, G.G., Barbafina, A., Canton, M., Dall'Acqua, F., Elisei, F., Facciolo, L., Latterini, L., Viola, G. Photochem. Photobiol. (2004) [Pubmed]
  2. Visual learning in individually assayed Drosophila larvae. Gerber, B., Scherer, S., Neuser, K., Michels, B., Hendel, T., Stocker, R.F., Heisenberg, M. J. Exp. Biol. (2004) [Pubmed]
  3. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance? Anderson, T.J., Nair, S., Qin, H., Singlam, S., Brockman, A., Paiphun, L., Nosten, F. Antimicrob. Agents Chemother. (2005) [Pubmed]
  4. Transformation of renal tubule epithelial cells by simian virus-40 is associated with emergence of Ca(2+)-insensitive K+ channels and altered mitogenic sensitivity to K+ channel blockers. Teulon, J., Ronco, P.M., Geniteau-Legendre, M., Baudouin, B., Estrade, S., Cassingena, R., Vandewalle, A. J. Cell. Physiol. (1992) [Pubmed]
  5. Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity. Garrido, M.J., Sayar, O., Segura, C., Rapado, J., Dios-Vieitez, M.C., Renedo, M.J., Troconiz, I.F. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  6. Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. ter Kuile, F., White, N.J., Holloway, P., Pasvol, G., Krishna, S. Exp. Parasitol. (1993) [Pubmed]
  7. In vitro drug sensitivity and clinical aspects of Plasmodium falciparum malaria in African children. Carme, B., Gay, F., Ndounga, M., Hayette-Gorremans, M.P., Bouquety, J.C. Trop. Med. Parasitol. (1995) [Pubmed]
  8. Antimalarials inhibit human erythrocyte membrane acetylcholinesterase. Katewa, S.D., Katyare, S.S. Drug and chemical toxicology. (2005) [Pubmed]
  9. Alternative method for determination of pyrimethamine in plasma by high-performance liquid chromatography. Na-Bangchang, K., Tan-ariya, P., Ubalee, R., Kamanikom, B., Karbwang, J. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
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