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Chemical Compound Review:

CPD-704 4-nitrobenzoate

Synonyms: SureCN187708, ZINC01688307, AC1NA1ZT, A833662, 4NBZate, ...

This record was replaced with 6108.

Parales, R.E., Wardman, P. et al., Peres, C.M. et al., Michán, C. et al., Hughes, M.A. et al., et al.

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Disease relevance of p-Nitrobenzoic acid

Cloning and characterization of the pnb genes, encoding enzymes for 4-nitrobenzoate catabolism in Pseudomonas putida TW3 [1].
Although isolated on 4-aminobenzoate, Burkholderia cepacia strain PB4 is also able to grow on 4-nitrobenzoate [2].
Novel degradative pathway of 4-nitrobenzoate in Comamonas acidovorans NBA-10 [3].

High impact information on p-Nitrobenzoic acid

In contrast, strain 4NT did not respond to any aromatic acids when grown with 4-nitrotoluene or 4-nitrobenzoate, apparently because these substrates are not metabolized to the inducer (beta-ketoadipate) of the chemotaxis system [4].
The TOL pWW0 delta pm plasmid converts 4-nitrotoluene into 4-nitrobenzoate through its upper pathway, but it does not metabolize 4-nitrobenzoate [5].
Pulse radiolysis was used to establish one-electron transfer equilibria between radical cations of methyl or benzyl viologens (V2+) and nitroaryl compounds (ArNO2): a nitroimidazole (misonidazole or metronidazole), 4-nitrobenzoate or nitrofurazone [6].

Biological context of p-Nitrobenzoic acid

The broad specificity of this chemotaxis system works as an advantage in strains TW3 and 4NT because it functions to detect diverse carbon sources, including 4-nitrobenzoate [4].

References

Cloning and characterization of the pnb genes, encoding enzymes for 4-nitrobenzoate catabolism in Pseudomonas putida TW3. Hughes, M.A., Williams, P.A. J. Bacteriol. (2001) [Pubmed]
Continuous degradation of mixtures of 4-nitrobenzoate and 4-aminobenzoate by immobilized cells of Burkholderia cepacia strain PB4. Peres, C.M., Van Aken, B., Naveau, H., Agathos, S.N. Appl. Microbiol. Biotechnol. (1999) [Pubmed]
Novel degradative pathway of 4-nitrobenzoate in Comamonas acidovorans NBA-10. Groenewegen, P.E., Breeuwer, P., van Helvoort, J.M., Langenhoff, A.A., de Vries, F.P., de Bont, J.A. J. Gen. Microbiol. (1992) [Pubmed]
Nitrobenzoates and aminobenzoates are chemoattractants for Pseudomonas strains. Parales, R.E. Appl. Environ. Microbiol. (2004) [Pubmed]
In vivo construction of a hybrid pathway for metabolism of 4-nitrotoluene in Pseudomonas fluorescens. Michán, C., Delgado, A., Haïdour, A., Lucchesi, G., Ramos, J.L. J. Bacteriol. (1997) [Pubmed]
Temperature effects on the one-electron reduction potentials of nitroaryl compounds. Wardman, P., Clarke, E.D. Free Radic. Res. Commun. (1991) [Pubmed]

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