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Chemical Compound Review

PNBA     4-nitrobenzoic acid

Synonyms: LS-43, PubChem15437, SureCN43476, CHEMBL101263, NSC-7707, ...
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Disease relevance of p-Nitrobenzoic acid


High impact information on p-Nitrobenzoic acid

  • These isolates could be differentiated from other slowly growing pigmented mycobacteria by their inability to grow at 37 degrees C, production of niacin and urease, absence of nitrate reductase, negative Tween 80 hydrolysis and resistance to isoniazid (1 mug ml(-1)), p-nitrobenzoic acid, thiacetazone and thiophene-2-carboxylic hydrazide [6].
  • However, when an aqueous anaerobic solution (pH 10) of PBSA and either nitromethane (NM) or 4-nitrobenzoic acid (4-NBA) were irradiated, the corresponding nitro anion radicals were observed [7].
  • 3. Caecal bacterial biotransformation activities (beta-glucosidase (EC, beta-glucuronidase (EC, reduction of p-nitrobenzoic acid, apparent ammonia formation) were consistently decreased by both ARS sources [8].
  • 1. A semi-synthetic diet, the semi-synthetic diet plus pectin, and a stock diet were fed to rats, and three metabolic functions of the caecal bacteria (reduction of amaranth, p-nitrobenzoic acid and nitrate) were measured in vitro [9].
  • 1. Hepatic microsomal drug metabolism determined with the substrates aniline (p-hydroxylation), ethylmorphine (N-demethylation) and p-nitrobenzoic acid (reduction), decreased during gestation in the rat to 53-73% of non-pregnant control levels by day 20 of gestation [10].

Chemical compound and disease context of p-Nitrobenzoic acid


Biological context of p-Nitrobenzoic acid


Anatomical context of p-Nitrobenzoic acid


Associations of p-Nitrobenzoic acid with other chemical compounds


Gene context of p-Nitrobenzoic acid


Analytical, diagnostic and therapeutic context of p-Nitrobenzoic acid


  1. Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Rafii, F., Hansen, E.B. Antimicrob. Agents Chemother. (1998) [Pubmed]
  2. The relationship between nitro group reduction and the intestinal microflora. Wheeler, L.A., Soderberg, F.B., Goldman, P. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  3. Selective inhibition of the Mycobacterium tuberculosis complex by p-nitro-alpha-acetylamino-beta-hydroxypropio phenone (NAP) and p-nitrobenzoic acid (PNB) used in 7H11 agar medium. Rastogi, N., Goh, K.S., David, H.L. Res. Microbiol. (1989) [Pubmed]
  4. Radiometric studies on the use of selective inhibitors in the identification of Mycobacterium spp. Collins, T., Levett, P.N. J. Med. Microbiol. (1989) [Pubmed]
  5. P-Nitrobenzoic acid alpha2u nephropathy in 13-week studies is not associated with renal carcinogenesis in 2-year feed studies. Williams, K.D., Dunnick, J., Horton, J., Greenwell, A., Eldridge, S.R., Elwell, M., Sills, R.C. Toxicologic pathology. (2001) [Pubmed]
  6. Mycobacterium pseudoshottsii sp. nov., a slowly growing chromogenic species isolated from Chesapeake Bay striped bass (Morone saxatilis). Rhodes, M.W., Kator, H., McNabb, A., Deshayes, C., Reyrat, J.M., Brown-Elliott, B.A., Wallace, R., Trott, K.A., Parker, J.M., Lifland, B., Osterhout, G., Kaattari, I., Reece, K., Vogelbein, W., Ottinger, C.A. Int. J. Syst. Evol. Microbiol. (2005) [Pubmed]
  7. Photophysical and photochemical studies of 2-phenylbenzimidazole and UVB sunscreen 2-phenylbenzimidazole-5-sulfonic acid. Inbaraj, J.J., Bilski, P., Chignell, C.F. Photochem. Photobiol. (2002) [Pubmed]
  8. Influence of starches of low digestibility on the rat caecal microflora. Mallett, A.K., Bearne, C.A., Young, P.J., Rowland, I.R., Berry, C. Br. J. Nutr. (1988) [Pubmed]
  9. Dietary fibre, bacterial metabolism and toxicity of nitrate in the rat. Wise, A., Mallett, A.K., Rowland, I.R. Xenobiotica (1982) [Pubmed]
  10. Hepatic microsomal drug metabolism in the pregnant rat. Symons, A.M., Turcan, R.G., Parke, D.V. Xenobiotica (1982) [Pubmed]
  11. Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (spy dust) and its metabolites in vitro and in vivo. Zeiger, E., Shelby, M.D., Ivett, J., McFee, A.F. Environmental mutagenesis. (1987) [Pubmed]
  12. Main metabolites of 1-(2-chloroethyl)-3-[1'-(5'-p-nitrobenzoyl-2',3'-isopropylidene)-alpha, beta-D-ribofuranosyl]-1-nitrosourea and 1-(2-chloroethyl)-3-(2',3', 4'-tri-O-acetyl-alpha, beta-D-ribopyranosyl)-1-nitrosourea in rats. Madelmont, J.C., Moreau, M.F., Godeneche, D., Duprat, J., Plagne, R., Meyniel, G. Drug Metab. Dispos. (1982) [Pubmed]
  13. The Hendrickson reagent and the Mitsunobu reaction: a mechanistic study. Elson, K.E., Jenkins, I.D., Loughlin, W.A. Org. Biomol. Chem. (2003) [Pubmed]
  14. 4-Nitrobenzoic acid reductase of the nematode Ascaris lumbricoides var suum. Localization of the enzyme and optimum assay conditions. Douch, P.G. Xenobiotica (1975) [Pubmed]
  15. Photoreactivity of chloramphenicol in vitro and in vivo. de Vries, H., Hemelaar, P.J., Gevers, A.C., Beyersbergen van Henegouwen, G.M. Photochem. Photobiol. (1994) [Pubmed]
  16. The effects of the continuous administration of N,N-dimethyl-4-phenylazoaniline (DAB) on the activities and the inducibilities of some drug-metabolizing enzymes in rat liver. Autrup, H., Thurlow, B.J., Warwick, G.P. Chem. Biol. Interact. (1975) [Pubmed]
  17. The effect of flavins and enzyme inhibitors on 4-nitrobenzoic acid reductase and azo reductase of Ascaris lumbricoides var suum. Douch, P.G. Xenobiotica (1975) [Pubmed]
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