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Chemical Compound Review

ethyron     ethylsulfanylmethanimidamide

Synonyms: Lopac-E-3149, Tocris-0873, CHEMBL321691, CHEBI:43633, CHEBI:275077, ...
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High impact information on ethylsulfanylmethanimidamide


Biological context of ethylsulfanylmethanimidamide


Anatomical context of ethylsulfanylmethanimidamide


Associations of ethylsulfanylmethanimidamide with other chemical compounds


Gene context of ethylsulfanylmethanimidamide

  • The NOS inhibitor ethylisothiourea, used for control purposes, showed a hypertensive effect in eNOS+/+ mice, but no such effect in eNOS-/- mice [16].

Analytical, diagnostic and therapeutic context of ethylsulfanylmethanimidamide

  • 1. The aim of this study was to compare the effects of an intravenous infusion of a potent and non selective nitric oxide synthase inhibitor S-ethylisothiourea (Ethyl-TU) with that of a nitric oxide (NO) donor on the pathological sequelae associated with splanchnic artery occlusion (SAO) shock [17].
  • More specifically, EITU failed to influence transcription of iNOS mRNA (Northern blot analysis), translation of iNOS protein (pulse experiments), or degradation of translated iNOS protein (pulse-chase experiments) [11].


  1. Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus. Rairigh, R.L., Le Cras, T.D., Ivy, D.D., Kinsella, J.P., Richter, G., Horan, M.P., Fan, I.D., Abman, S.H. J. Clin. Invest. (1998) [Pubmed]
  2. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Fischmann, T.O., Hruza, A., Niu, X.D., Fossetta, J.D., Lunn, C.A., Dolphin, E., Prongay, A.J., Reichert, P., Lundell, D.J., Narula, S.K., Weber, P.C. Nat. Struct. Biol. (1999) [Pubmed]
  3. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. Garvey, E.P., Oplinger, J.A., Tanoury, G.J., Sherman, P.A., Fowler, M., Marshall, S., Harmon, M.F., Paith, J.E., Furfine, E.S. J. Biol. Chem. (1994) [Pubmed]
  4. Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands. Stevenson, T.H., Gutierrez, A.F., Alderton, W.K., Lian , L., Scrutton, N.S. Biochem. J. (2001) [Pubmed]
  5. Contribution of nitric oxide produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in streptozotocin-diabetic rats. Ishikawa, T., Kohno, F., Kawase, R., Yamamoto, Y., Nakayama, K. Br. J. Pharmacol. (2004) [Pubmed]
  6. Selective inhibition of inducible nitric oxide synthase: effects on hemodynamics and regional blood flow in healthy and septic sheep. Booke, M., Hinder, F., McGuire, R., Traber, L.D., Traber, D.L. Crit. Care Med. (1999) [Pubmed]
  7. S-ethylisothiourea, a nonamino acid inhibitor of nitric oxide synthase, reverses septic vasodilation in sheep. Booke, M., Hinder, F., Traber, L.D., McGuire, R., Traber, D.L. Shock (1995) [Pubmed]
  8. Inhibition of nitric oxide synthase by isothioureas: cardiovascular and antinociceptive effects. Handy, R.L., Wallace, P., Moore, P.K. Pharmacol. Biochem. Behav. (1996) [Pubmed]
  9. Effect of S-ethylisothiourea, a putative inhibitor of inducible nitric oxide synthase, on mouse skin vascular permeability. Muraki, T., Fujii, E., Okada, M., Horikawa, H., Irie, K., Ohba, K. Jpn. J. Pharmacol. (1996) [Pubmed]
  10. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis. Fiala, M., Murphy, T., MacDougall, J., Yang, W., Luque, A., Iruela-Arispe, L., Cashman, J., Buga, G., Byrns, R.E., Barbaro, G., Arthos, J. Cardiovasc. Toxicol. (2004) [Pubmed]
  11. Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein. Wei, L.H., Arabolos, N., Ignarro, L.J. Nitric Oxide (1998) [Pubmed]
  12. Deferoxamine reduces and nitric oxide synthase inhibition increases neutrophil-mediated myotube injury. McLoughlin, T.J., Tsivitse, S.K., Edwards, J.A., Aiken, B.A., Pizza, F.X. Cell Tissue Res. (2003) [Pubmed]
  13. Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits. Seo, H.G., Fujiwara, N., Kaneto, H., Asahi, M., Fujii, J., Taniguchi, N. J. Biochem. (1996) [Pubmed]
  14. Inactivation of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPase by N-cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide. Chadwick, C.C., Thomas, E.W. Biochim. Biophys. Acta (1983) [Pubmed]
  15. Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase. Hurwitz, A., Finci-Yeheskel, Z., Milwidsky, A., Mayer, M. Reproduction (2002) [Pubmed]
  16. Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene. Wallerath, T., Gödecke, A., Molojavyi, A., Li, H., Schrader, J., Förstermann, U. Nitric Oxide (2004) [Pubmed]
  17. Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Squadrito, F., Altavilla, D., Squadrito, G., Campo, G.M., Ioculano, M., Canale, P., Rossi, F., Saitta, A., Caputi, A.P. Br. J. Pharmacol. (1996) [Pubmed]
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