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Chemical Compound Review:

FRAXINE 7-hydroxy-6-methoxy-8- [(2S,3R,4S,5S,6R)-3...

Synonyms: Fraxin, CHEMBL293864, MEGxp0_000484, STOCK1N-14640, AC1NRV6B, ...

Whang, W.K. et al., Sivitz, A.B. et al., Li, C. et al.

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High impact information on Fraxin

AtSUC9 showed low substrate specificity, similar to AtSUC2 (At1g22710), and transported a wide range of glucosides, including helicin, salicin, arbutin, maltose, fraxin, esculin, turanose, and alpha-methyl-d-glucose [1].
Differential display reverse transcription-PCR revealed that fraxin upregulated antiapoptotic genes (clusterin and apoptosis inhibitor 5) and tumor suppressor gene (ST13) [2].
Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress [2].
A non-aqueous capillary electrophoresis method has been developed for the separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its preparation for the first time [3].
The purpose of this study is to investigate cellular protective activity of coumarin compound, fraxin extracted from Weigela florida var. glabbra, under oxidative stress, to identify genes expressed differentially by fraxin and to compare antioxidative effect of fraxin with its structurally related chemicals [2].

Biological context of Fraxin

Fraxin recovered viability of HUVECs damaged by H2O2-treatment and reduced the lipid peroxidation and the internal reactive oxygen species level elevated by H2O2 treatment [2].

Anatomical context of Fraxin

Of the coumarins, protective effects of fraxin against cytotoxicity induced by H2O2 were examined in human umbilical vein endothelial cells (HUVECs) [2].

References

Arabidopsis Sucrose Transporter AtSUC9. High-Affinity Transport Activity, Intragenic Control of Expression, and Early Flowering Mutant Phenotype. Sivitz, A.B., Reinders, A., Johnson, M.E., Krentz, A.D., Grof, C.P., Perroux, J.M., Ward, J.M. Plant Physiol. (2007) [Pubmed]
Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Whang, W.K., Park, H.S., Ham, I., Oh, M., Namkoong, H., Kim, H.K., Hwang, D.W., Hur, S.Y., Kim, T.E., Park, Y.G., Kim, J.R., Kim, J.W. Exp. Mol. Med. (2005) [Pubmed]
Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its medicinal preparations. Li, C., Chen, A., Chen, X., Ma, X., Chen, X., Hu, Z. Biomed. Chromatogr. (2005) [Pubmed]

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