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Chemical Compound Review

CHEBI:53146     (3E)-6,6-dihydroxy-2-oxo- hexa-3,5-dienoic...

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Disease relevance of C02501


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  • This observation together with the low K(m) of 2-hydroxymuconate (0.47 mM) suggests that only the tight binding sites function catalytically in the R39Q mutant [4].
  • Its catalytic products from 2-aminomuconate and 2-amino-5-chloromuconate were 2-hydroxymuconate and 2-hydroxy-5-chloromuconate, respectively, which are different from those previously reported for the deaminases of Pseudomonas species [5].
  • Both catechol 1,2- and 2,3-dioxygenase activities were present, and these were separated from each other and from the activities of cis-glycol dehydrogenase and 2-hydroxymuconic acid semialdehyde hydrolase by ion-exchange chromatography of extracts [6].
  • NAH2 determines the constitutive production of low concentrations of catechol 2,3-dioxygenase and 2-hydroxymuconic acid semialdehyde dehydrogenase, and NAH3 determines the constitutive production of high concentration of these [7].


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  4. Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase. Harris, T.K., Czerwinski, R.M., Johnson, W.H., Legler, P.M., Abeygunawardana, C., Massiah, M.A., Stivers, J.T., Whitman, C.P., Mildvan, A.S. Biochemistry (1999) [Pubmed]
  5. A Novel Deaminase Involved in Chloronitrobenzene and Nitrobenzene Degradation with Comamonas sp. Strain CNB-1. Liu, L., Wu, J.F., Ma, Y.F., Wang, S.Y., Zhao, G.P., Liu, S.J. J. Bacteriol. (2007) [Pubmed]
  6. Metabolism of styrene by Rhodococcus rhodochrous NCIMB 13259. Warhurst, A.M., Clarke, K.F., Hill, R.A., Holt, R.A., Fewson, C.A. Appl. Environ. Microbiol. (1994) [Pubmed]
  7. Naphthalene plasmids in pseudomonads. Connors, M.A., Barnsley, E.A. J. Bacteriol. (1982) [Pubmed]
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