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Gene Review

nahH  -  catechol 2,3-dioxygenase

Pseudomonas putida ND6

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Disease relevance of nahH


High impact information on nahH


Chemical compound and disease context of nahH


Biological context of nahH

  • The lapR gene is transcribed independently and encodes a member of the XylR/DmpR positive transcriptional regulators. lapB, the first gene in the lap operon, encodes catechol 2,3-dioxygenase (C23O) [13].
  • 3- and 4-alkylphenol degradation pathway in Pseudomonas sp. strain KL28: genetic organization of the lap gene cluster and substrate specificities of phenol hydroxylase and catechol 2,3-dioxygenase [13].
  • Gene sequence conservation, highlighted by examining the phylogeny of Proteobacterial catechol 2,3-dioxygenase sequences, reveals that sequences generally cluster in a manner which correlates with the taxonomic grouping of the Proteobacterial subgroup from which they originated [14].
  • By site directed homologous recombination a KX cassette [kanamycin resistance (kanr) and catechol 2,3 dioxygenase (xylE)] and a ZY cassette [lactose utilization (lacZY, beta-galactosidase, lactose permease)] were introduced at least 1 Mbp apart on the 6.6 Mbp bacterial chromosome [15].
  • The inhibited regime resulted in a 60% lower growth yield, near constant levels of C23D monomer, but a 50% reduction in the specific activity of C23D, increased RNA synthesis rates (total and aniline pathway mRNA), and elevated RNA decay rates [16].

Associations of nahH with chemical compounds


Analytical, diagnostic and therapeutic context of nahH


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  12. Preliminary study on relationships among strains forming a bacterial community selected on naphthalene from a marine sediment. Tagger, S., Truffaut, N., Le Petit, J. Can. J. Microbiol. (1990) [Pubmed]
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  18. Cloning of cmpE, a plasmid-borne catechol 2,3-dioxygenase-encoding gene from the aromatic- and chloroaromatic-degrading Pseudomonas sp. HV3. Yrjälä, K., Paulin, L., Kilpi, S., Romantschuk, M. Gene (1994) [Pubmed]
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  20. Simultaneous biodegradation of chlorobenzene and toluene by a Pseudomonas strain. Pettigrew, C.A., Haigler, B.E., Spain, J.C. Appl. Environ. Microbiol. (1991) [Pubmed]
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  23. Mass spectrometric mapping of the enzymes involved in the phenol degradation of an indigenous soil pseudomonad. Tsirogianni, I., Aivaliotis, M., Karas, M., Tsiotis, G. Biochim. Biophys. Acta (2004) [Pubmed]
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