Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NSKHU (8S,9S,10R,13S,14S,17S)-17- (2...

Synonyms: SureCN141610, NSC 9702, UNII-FO4V44A3G3, EINECS 200-776-2, 17-Deoxycortisone, ...

Ackermann, D. et al., López Bernal, A. et al., Nath, N. et al., Robinzon, B. et al., Maser, E., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Dehydrocorticosterone

Cortical collecting tubules (CCT) were isolated by microdissection and used for measurements of the activity of 11beta-HSD2 by assessing the conversion of corticosterone to dehydrocorticosterone [1].
Kinetics of glucocorticoid oxidoreduction were determined with corticosterone and dehydrocorticosterone as substrates for oxidation and reduction, respectively [2].
11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) is the enzyme that catalyzes the reversible oxidation of the biologically active steroid cortisol and corticosterone to their inactive metabolites cortisone and dehydrocorticosterone [3].
Dehydrocorticosterone inhibited the reduction to both isomers by pig liver microsomes, but only to 7 alpha-OH-DHEA by human microsomes; CBX inhibited both reactions [4].
Only the decidua could convert cortisone and DHC to the biologically more active cortisol and corticosterone, respectively [5].

Associations of Dehydrocorticosterone with other chemical compounds

Tritiated cortisol, cortisone, corticosterone, 11-dehydrocorticosterone (DHC) and 11-deoxycorticosterone (DOC) were incubated in vitro with homogenates of these tissues and extracts chromatographed on Sephadex LH20 columns [5].

Analytical, diagnostic and therapeutic context of Dehydrocorticosterone

Serum concentrations of corticosterone and dehydrocorticosterone in the DHEAS group were significantly (P < 0.05) lower than those of the control group [6].

References

Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis. Ackermann, D., Vogt, B., Escher, G., Dick, B., Reichen, J., Frey, B.M., Frey, F.J. Hepatology (1999) [Pubmed]
11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes. Maser, E. Cancer Res. (1998) [Pubmed]
Presence of 11 beta-hydroxysteroid dehydrogenase enzyme in the human prostate tumor cell line LNCaP. Nath, N., Lakshmi, V., Rosenthal, J.C. Prostate (1993) [Pubmed]
Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases? Robinzon, B., Michael, K.K., Ripp, S.L., Winters, S.J., Prough, R.A. Arch. Biochem. Biophys. (2003) [Pubmed]
Corticosteroid metabolism in vitro by human placenta, fetal membranes and decidua in early and late gestation. López Bernal, A., Craft, I.L. Placenta (1981) [Pubmed]
Activation of 11 beta-hydroxysteroid dehydrogenase by dehydroepiandrosterone sulphate as an anti-hypertensive agent in spontaneously hypertensive rats. Homma, M., Onodera, T., Hirabatake, M., Oka, K., Kanazawa, M., Miwa, T., Hayashi, T. J. Pharm. Pharmacol. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.