Disease relevance of Cannabigerol

• As cannabigerol lacked these toxicities, it appears that the ocular hypotensive effect of this cannabinoid is somewhat dissociable from both the adverse central and ocular effects accompanying marihuana intake [1].
• Cannabinol but not cannabigerol caused conjunctival erythema and hyperemia [1].

High impact information on Cannabigerol

• Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol [1].
• Botanical definitions include inactive substances such as cannabigerol, as well as alkaloids and other secondary constituents of Cannabis sativa, but exclude synthetics such as levonantradol and nabilone [2].
• OBJECTIVE: We investigated the plant cannabinoids Delta-9 tetrahydrocannabinol, cannabidiol, cannabinol and cannabigerol for their ability to inhibit the proliferation of a hyper-proliferating human keratinocyte cell line and for any involvement of cannabinoid receptors [3].
• The metabolism of delta-9-tetrahydrocannabinol (delta-9-THC), delta-8-THC, delta-11-THC, cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabigerol (CBG) and the equatorial-isomer of hexahydrocannabinol (HHC) was studied in microsomal preparations obtained from rats, mice, guinea pigs, rabbits, hamsters, gerbils and a cat [4].
• Neither delta 9-THC nor cannabigerol altered the rate of formation of aqueous humor [5].

References