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Chemical Compound Review:

AC1NSZTK 5-hydroxy-2-(4- hydroxyphenyl)-7- [(2R,3R,4S...

Synonyms:

Wistuba, D. et al., McIntosh, C.A. et al., Soria, F. et al., Choi, J.S. et al., Garcia-Mas, J. et al.

Wistuba, Trapp, Gel-Moreto, Galensa, Schurig,

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Disease relevance of Prunin

Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin [1].

High impact information on Prunin

Temperature- and pH-dependent enantiomerization or epimerization barriers of several flavanones (naringenin, homoeriodictyol) and flavanone-7-O-glycosides (naringin, neohesperidin, prunin, narirutin) in basic media (pH values of 9-11) have been observed [2].
Both prunin and oleosin genes are present in one or two copies in the almond genome [3].
This new enzyme in the subclass 2.4.1 catalyzes the glucosylation of the 7-OH group of naringenin (4',5',7-trihydroxyflavanone) to prunin and has been purified (943-fold) by fractional precipitation with ammonium sulfate and successive chromatography on Sephadex G-100, hydroxyapatite, UDP-glucuronic acid agarose, Mono Q, and Mono P columns [4].
7. Maximum activity of the beta-D-glucosidases was from pH 4 to 6 and at 65 degrees C. Both glucosidases were active on p -nitrophenol glucoside and prunin with respective Km values of 1.9 mm and 1.6 mm for beta G1 and 2.1 mm and 0.25 mm for beta G2 [5].

References

Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, prunin. Choi, J.S., Yokozawa, T., Oura, H. Planta Med. (1991) [Pubmed]
Stereoisomeric separation of flavanones and flavanone-7-O-glycosides by capillary electrophoresis and determination of interconversion barriers. Wistuba, D., Trapp, O., Gel-Moreto, N., Galensa, R., Schurig, V. Anal. Chem. (2006) [Pubmed]
Molecular characterization of cDNAs corresponding to genes expressed during almond (Prunus amygdalus Batsch) seed development. Garcia-Mas, J., Messeguer, R., Arús, P., Puigdomènech, P. Plant Mol. Biol. (1995) [Pubmed]
Flavanone-specific 7-O-glucosyltransferase activity in Citrus paradisi seedlings: purification and characterization. McIntosh, C.A., Latchinian, L., Mansell, R.L. Arch. Biochem. Biophys. (1990) [Pubmed]
Fractionation of the naringinase complex from Aspergillus terreus by dye affinity chromatography. Soria, F., Ellenrieder, G., Grasselli, M., Navarro del Cañizo, A.A., Cascone, O. Biotechnol. Lett. (2004) [Pubmed]

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