Disease relevance of Butantrone

• In the butantrone groups, there was only one single papilloma with the 1.5 mM concentration plus DMBA [1].
• Clinical trials with butantrone on psoriasis are justified [2].
• When short contact treatment is used, erythema and staining with butantrone are weaker than with dithranol [3].
• Dithranol and butantrone did not produce any chemical, hematological or serious histological abnormalities during the treatment, suggesting a lack of systemic toxicity [4].

Psychiatry related information on Butantrone

• At 0.5% and 1.0% strengths, butantrone produced significant levels of irritation and staining with minimal clinical response and poor patient compliance [5].

High impact information on Butantrone

• The tumor-producing and skin-irritating activity of the antipsoriatic drug dithranol and its 10-acyl analogues butantrone (10-butyryl dithranol), 10-isobutyryl dithranol and 10-valeryl dithranol were studied in 650 SENCAR mice using a two-stage skin carcinogenesis assay [6].
• In contrast to their stimulatory effects on liposomal membrane peroxidation, both anthralin and butantrone diminished Fe3+/ascorbate-induced lipid peroxidation in liposomes [7].
• The highest (10(-5) M) concentration of butantrone caused an abrupt decrease in cell number [8].
• Non-confluent monolayers of HeLa cells were treated with various concentrations (10(-5)-10(-8) M) of dithranol or butantrone for 45 min [8].
• Short-contact therapy for psoriasis with 3.9% butantrone (10-butyryl dithranol) [9].

Biological context of Butantrone

• Intact butantrone rather than its hydrolysis product was the primary effector and the 10-butyryl moiety its site specific probe, probably directing the inhibitor to the proximity of the binding site of the lipid substrate/product [10].

Analytical, diagnostic and therapeutic context of Butantrone

• This long-term study did not predict delayed irritation of butantrone observed in about 1/3 of the psoriatic patients after treatment for 1-2 months [4].
• Continuous topical administration of dithranol and butantrone for 6 months caused different irritation profiles in miniature swine [4].

References