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MeSH Review

Swine, Miniature

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Disease relevance of Swine, Miniature


High impact information on Swine, Miniature

  • Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital [6].
  • We have previously shown that indefinite systemic tolerance to renal allografts in miniature swine is induced in 100% of cases across a two-haplotype class I plus minor histocompatibility antigen disparity by a 12-d course of Cyclosporine A (CyA), in contrast to irreversible rejection observed uniformly without CyA treatment [7].
  • We compared the effects of 1-yr treatment of 9-mo-old minipigs with sodium fluoride (NaF, 2 mg/kg/d p.o.) or alendronate (ALN, 4 amino-1-hydroxybutylidene bisphosphonate monosodium, 1 mg/kg/d p.o.) on the biomechanical and histomorphometric properties of pig bones [8].
  • METHODS: Mature Goettingen minipigs were treated with solvent (n = 5), EGF (30; n = 6) for 4 weeks, or EGF (30; n = 5) for 5 weeks followed by 3 weeks of recovery [9].
  • Previously, we generated inbred miniature swine with a null allele of the alpha-1,3-galactosyltransferase locus (GGTA1) by nuclear transfer (NT) with gene-targeted fibroblasts [10].

Chemical compound and disease context of Swine, Miniature


Biological context of Swine, Miniature

  • Molecular characterization of porcine MHC class I clones from two MHC class I loci (P1 and P14) obtained from homozygous inbred miniature swine of three haplotypes (aa, cc, and dd), revealed extensive conservation between loci, suggesting that the genes were products of duplication from a common ancestral sequence [16].
  • Immune tolerance to MHC class II identical renal grafts is achievable in miniature swine following a short immunosuppressive treatment [17].
  • This study examines the vascular sampling site, insulin kinetics, pulsatility and the response to glucose pulse entrainment to evaluate the Göttingen minipig as a model for studying pulsatile insulin secretion [18].
  • Application of different NOS-inhibitors in humans, minipigs, and dogs decreased NOS-activity and thereby increased vascular resistance [19].
  • Contribution of intestinal microbial lysine to lysine homeostasis is reduced in minipigs fed a wheat gluten-based diet [20].

Anatomical context of Swine, Miniature


Associations of Swine, Miniature with chemical compounds

  • METHODS AND RESULTS: We investigated the effects of 17 beta-estradiol (E2) on endothelial vasomotor function in cholesterol-fed miniature swine [26].
  • METHODS AND RESULTS: Thirty-two Götingen minipigs were randomized as control diet-fed (C), captopril (25 mg/d)/hydrochlorothiazide (12.5 mg/d)-treated C (C+Cp), caseinate-based diet-fed (M), and M+Cp minipigs [27].
  • Minipigs on a methionine-rich caseinate-based diet, however, have a special long-lasting postprandial plasma accumulation of methionine, the metabolic precursor of homocysteine [27].
  • Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species [28].
  • The purpose of the present study was to determine the maximal coronary flow reserve (CFR) before and after the administration of successive cocaine doses (0.1, 0.5, 3, and 7 mg/kg IV) for 2 minutes at 10-minute intervals in eight miniature swine [29].

Gene context of Swine, Miniature

  • Docetaxel was metabolized in pig, minipig, rat, and human liver microsomes mainly to hydroxydocetaxel (OHDTX), whereas CYP3A-induced rat microsomes produced primarily diastereomeric hydroxyoxazolidinones [30].
  • The nifedipine oxidase activity and testosterone 6beta-hydroxylating activity (specific markers for CYP3A enzymes) of the human liver microsomal and minipig liver microsomal samples were comparable, as were the results of specific inhibition of this activity by triacetyloleandomycin [31].
  • The activity of CYP2E1 was 4 times higher in female than in male minipigs and 2 times higher in female than in male pigs [32].
  • From comparisons, it can be concluded that the sequence of the first 20 amino acids at the N-terminus of minipig CYP2A is highly similar to human CYP2A6 (70% identity) [33].
  • CONCLUSIONS: Thus, our results further support the view that minipigs may serve as model animals in pharmacological/toxicological studies with substrates of human CYP enzymes, namely, of the CYP3A and CYP2A forms [33].

Analytical, diagnostic and therapeutic context of Swine, Miniature


  1. Hemodynamic effect of the nitroxide superoxide dismutase mimics. Hahn, S.M., Sullivan, F.J., DeLuca, A.M., Bacher, J.D., Liebmann, J., Krishna, M.C., Coffin, D., Mitchell, J.B. Free Radic. Biol. Med. (1999) [Pubmed]
  2. The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs. Hasegawa, N., Oka, Y., Nakayama, M., Berry, G.J., Bursten, S., Rice, G., Raffin, T.A. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  3. Sustained retention of tetradecylthioacetic acid after local delivery reduces angioplasty-induced coronary stenosis in the minipig. Pettersen, R.J., Muna, Z.A., Kuiper, K.K., Svendsen, E., Müller, F., Aukrust, P., Berge, R.K., Nordrehaug, J.E. Cardiovasc. Res. (2001) [Pubmed]
  4. Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol. Bril, A., Slivjak, M., DiMartino, M.J., Feuerstein, G.Z., Linee, P., Poyser, R.H., Ruffolo, R.R., Smith, E.F. Cardiovasc. Res. (1992) [Pubmed]
  5. Uterine-specific proteins in luminal secretions of swine leukocyte antigen-inbred miniature swine with cystic endometrial hyperplasia. Segerson, E.C., Diehl, J.R., Stuart, L.D. Biol. Reprod. (1988) [Pubmed]
  6. Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital. Dees, J.H., Coe, L.D., Yasukochi, Y., Masters, B.S. Science (1980) [Pubmed]
  7. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. Yamada, K., Gianello, P.R., Ierino, F.L., Lorf, T., Shimizu, A., Meehan, S., Colvin, R.B., Sachs, D.H. J. Exp. Med. (1997) [Pubmed]
  8. Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study. Lafage, M.H., Balena, R., Battle, M.A., Shea, M., Seedor, J.G., Klein, H., Hayes, W.C., Rodan, G.A. J. Clin. Invest. (1995) [Pubmed]
  9. Systemic treatment with epidermal growth factor in pigs induces ductal proliferations in the pancreas. Vinter-Jensen, L., Juhl, C.O., Teglbjaerg, P.S., Poulsen, S.S., Dajani, E.Z., Nexø, E. Gastroenterology (1997) [Pubmed]
  10. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Kolber-Simonds, D., Lai, L., Watt, S.R., Denaro, M., Arn, S., Augenstein, M.L., Betthauser, J., Carter, D.B., Greenstein, J.L., Hao, Y., Im, G.S., Liu, Z., Mell, G.D., Murphy, C.N., Park, K.W., Rieke, A., Ryan, D.J., Sachs, D.H., Forsberg, E.J., Prather, R.S., Hawley, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. The DaNeX study of embryonic mesencephalic, dopaminergic tissue grafted to a minipig model of Parkinson's disease: preliminary findings of effect of MPTP poisoning on striatal dopaminergic markers. Danielsen, E.H., Cumming, P., Andersen, F., Bender, D., Brevig, T., Falborg, L., Gee, A., Gillings, N.M., Hansen, S.B., Hermansen, F., Johansen, J., Johansen, T.E., Dahl-Jørgensen, A., Jørgensen, H.A., Meyer, M., Munk, O., Pedersen, E.B., Poulsen, P.H., Rodell, A.B., Sakoh, M., Simonsen, C.Z., Smith, D.F., Sørensen, J.C., Ostergård, L., Zimmer, J., Gjedde, A. Cell transplantation. (2000) [Pubmed]
  12. Pulmonary vascular impedance response to hypoxia in dogs and minipigs: effects of inhaled nitric oxide. Maggiorini, M., Brimioulle, S., De Canniere, D., Delcroix, M., Wauthy, P., Naeije, R. J. Appl. Physiol. (1995) [Pubmed]
  13. Unilateral hypoxic pulmonary vasoconstriction in the dog, pony and miniature swine. Elliott, A.R., Steffey, E.P., Jarvis, K.A., Marshall, B.E. Respiration physiology. (1991) [Pubmed]
  14. Septicemia during pregnancy: a study in different species of experimental animals. Beller, F.K., Schmidt, E.H., Holzgreve, W., Hauss, J. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  15. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Parker, S.G., Taylor, E.M., Hamburger, S.A., Vimal, M., Kaumann, A.J. Naunyn Schmiedebergs Arch. Pharmacol. (1995) [Pubmed]
  16. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. Sullivan, J.A., Oettinger, H.F., Sachs, D.H., Edge, A.S. J. Immunol. (1997) [Pubmed]
  17. A particular TCR beta variable region used by T cells infiltrating kidney transplants. Baron, C., Sachs, D.H., LeGuern, C. J. Immunol. (2001) [Pubmed]
  18. The conscious Göttingen minipig as a model for studying rapid pulsatile insulin secretion in vivo. Larsen, M.O., Elander, M., Sturis, J., Wilken, M., Carr, R.D., Rolin, B., Pørksen, N. Diabetologia (2002) [Pubmed]
  19. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., Heusch, G., Schaub, G.A., Bryan, N.S., Feelisch, M., Kelm, M. Free Radic. Biol. Med. (2003) [Pubmed]
  20. Contribution of intestinal microbial lysine to lysine homeostasis is reduced in minipigs fed a wheat gluten-based diet. Backes, G., Hennig, U., Petzke, K.J., Elsner, A., Junghans, P., Nürnberg, G., Metges, C.C. Am. J. Clin. Nutr. (2002) [Pubmed]
  21. Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle-emitting stent. Laird, J.R., Carter, A.J., Kufs, W.M., Hoopes, T.G., Farb, A., Nott, S.H., Fischell, R.E., Fischell, D.R., Virmani, R., Fischell, T.A. Circulation (1996) [Pubmed]
  22. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Halsted, C.H., Villanueva, J., Chandler, C.J., Stabler, S.P., Allen, R.H., Muskhelishvili, L., James, S.J., Poirier, L. Hepatology (1996) [Pubmed]
  23. Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Göttingen minipig, a model of moderate insulin deficiency and diabetes. Larsen, M.O., Rolin, B., Wilken, M., Carr, R.D., Gotfredsen, C.F. Diabetes (2003) [Pubmed]
  24. A new balloon-expandable tantalum coil stent: angiographic patency and histologic findings in an atherogenic swine model. White, C.J., Ramee, S.R., Banks, A.K., Mesa, J.E., Chokshi, S., Isner, J.M. J. Am. Coll. Cardiol. (1992) [Pubmed]
  25. Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography. Borah, B., Dufresne, T.E., Chmielewski, P.A., Gross, G.J., Prenger, M.C., Phipps, R.J. J. Bone Miner. Res. (2002) [Pubmed]
  26. 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Keaney, J.F., Shwaery, G.T., Xu, A., Nicolosi, R.J., Loscalzo, J., Foxall, T.L., Vita, J.A. Circulation (1994) [Pubmed]
  27. Hyperhomocysteinemia-induced vascular damage in the minipig. Captopril-hydrochlorothiazide combination prevents elastic alterations. Rolland, P.H., Friggi, A., Barlatier, A., Piquet, P., Latrille, V., Faye, M.M., Guillou, J., Charpiot, P., Bodard, H., Ghiringhelli, O. Circulation (1995) [Pubmed]
  28. Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species. Gustafsson, K., Germana, S., Hirsch, F., Pratt, K., LeGuern, C., Sachs, D.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm. Núñez, B.D., Miao, L., Wang, Y., Núñez, M.M., Klein, M.A., Sellke, F.W., Ross, J.N., Susulic, V., Paik, G.Y., Carrozza, J.P. Circ. Res. (1994) [Pubmed]
  30. Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Vaclavikova, R., Soucek, P., Svobodova, L., Anzenbacher, P., Simek, P., Guengerich, F.P., Gut, I. Drug Metab. Dispos. (2004) [Pubmed]
  31. Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Anzenbacher, P., Soucek, P., Anzenbacherová, E., Gut, I., Hrubý, K., Svoboda, Z., Kvĕtina, J. Drug Metab. Dispos. (1998) [Pubmed]
  32. Cytochrome P450 sex differences in minipigs and conventional pigs. Skaanild, M.T., Friis, C. Pharmacol. Toxicol. (1999) [Pubmed]
  33. Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs. Soucek, P., Zuber, R., Anzenbacherová, E., Anzenbacher, P., Guengerich, F.P. BMC Pharmacol. (2001) [Pubmed]
  34. Transplantation in miniature swine. XII. N-terminal sequences of class I histocompatibility antigens (SLA) and beta 2-microglobulin. Metzger, J.J., Lunney, J.K., Sachs, D.H., Rudikoff, S. J. Immunol. (1982) [Pubmed]
  35. Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs. Buchwald, A.B., Wagner, A.H., Webel, C., Hecker, M. J. Am. Coll. Cardiol. (2002) [Pubmed]
  36. alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies. Dor, F.J., Tseng, Y.L., Cheng, J., Moran, K., Sanderson, T.M., Lancos, C.J., Shimizu, A., Yamada, K., Awwad, M., Sachs, D.H., Hawley, R.J., Schuurman, H.J., Cooper, D.K. Transplantation (2004) [Pubmed]
  37. Spontaneous acceptance or rejection of orthotopic liver transplants in outbred and partially inbred miniature swine. Flye, M.W., Pennington, L., Kirkman, R., Weber, B., Sindelar, W., Sachs, D.H. Transplantation (1999) [Pubmed]
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