The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

BW-B70C     1-[(E)-4-[3-(4- fluorophenoxy)phenyl]but-3...

Synonyms: CHEMBL86676, BWB70C, BW-B 70C, BSPBio_001512, B4558_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BW B70C


High impact information on BW B70C

  • The 5-lipoxygenase inhibitor, BW B70C, injected i.p. (30 mg/kg) prevented leukotriene C4 synthesis by alveolar macrophages and reduced leucocyte migration to the airways lumen as well as albumin microvascular leakage but did not affect the endotoxin-induced increase in the blood level of TNF-alpha and of secreted phospholipase A2 [4].
  • In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes, this priming effect being abrogated in the presence of BW B70C [5].
  • Furthermore, in vitro, BW-B 70C inhibited lipopolysaccharide (LPS) mediated nitric oxide production, iNOS induction and NF-kappaB activation in the BV2 microglial cell line [2].
  • Treating rat primary microglia with BW-B70C confirmed blockage of LPS-mediated translocation of the p65 subunit of NF-kappaB from cytosol to nucleus [2].
  • In the presence of Lyprinol, or of BW B70C, the hyper-activation of monocytes from allergic patients was significantly suppressed [6].

Gene context of BW B70C

  • Furthermore, the mechanism and the anti-inflammatory potential of BW-B 70C in the regulation of nuclear factor kappa B (NF-kappaB) and inflammatory inducible nitric oxide synthase (iNOS) were investigated both in vivo and in vitro [2].

Analytical, diagnostic and therapeutic context of BW B70C

  • Compound BW B70C, a selective 5-lipoxygenase inhibitor was tested for its ability to reduce inflammatory damage in an in vivo rabbit model of renal storage and transplantation [1].


  1. Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. Lane, N.J., Thorniley, M.S., Manek, S., Fuller, B.J., Green, C.J. Transplantation (1994) [Pubmed]
  2. Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. Jatana, M., Giri, S., Ansari, M.A., Elango, C., Singh, A.K., Singh, I., Khan, M. Journal of neuroinflammation [electronic resource]. (2006) [Pubmed]
  3. Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Yeadon, M., Dougan, F.L., Petrovic, A., Beesley, J.E., Payne, A.N. Agents Actions (1993) [Pubmed]
  4. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. Bureau, M.F., De Castro, C.M., Cortese, C., Bachelet, M., Vargaftig, B.B. Eur. J. Pharmacol. (1997) [Pubmed]
  5. Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation. Dugas, N., Dugas, B., Kolb, J.P., Yamaoka, K., Delfraiss, J.F., Damais, C. Immunology (1996) [Pubmed]
  6. Lyprinol inhibits LTB4 production by human monocytes. Dugas, B. Allergie et immunologie. (2000) [Pubmed]
WikiGenes - Universities