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Chemical Compound Review

AC1L1GFU     diethyl-[2-(3-methyl-2- phenyl...

Synonyms: LS-75346, C 2003, 78266-03-2
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Disease relevance of 3-methyl-2-phenyl-hexanoic acid 2-diethylaminoethyl ester

  • We have recently reported that osteopontin (OPN) stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase-type plasminogen activator (uPA) through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells (Das, R., Mahabeleshwar, G. H., and Kundu, G. C. (2003) J. Biol. Chem. 278, 28593-28606) [1].

High impact information on 3-methyl-2-phenyl-hexanoic acid 2-diethylaminoethyl ester

  • We have previously reported (Dobreva, I., Waeber, G., Mooser, V., James, R. W., and Widmann, C. (2003) J. Lipid Res. 44, 2382-2390) that low density lipoproteins (LDLs) induce activation of the p38 MAPK pathway, resulting in fibroblast spreading and lamellipodia formation [2].
  • Recently, we demonstrated that Nodal mRNA and several ALK7 transcripts are expressed in human placenta throughout pregnancy (Roberts, H. J., Hu, S., Qiu, Q., Leung, P. C. K., Cannigia, I., Gruslin, A., Tsang, B., and Peng, C. (2003) Biol. Reprod. 68, 1719-1726) [3].
  • This increased adhesion is mediated primarily through induction of interleukin (IL)-8 via activation of the transcription factor AP-1 (Srinivasan, S., Yeh, M., Danziger, E. C., Hatley, M. E., Riggan, A. E., Leitinger, N., Berliner, J. A., and Hedrick, C. C. (2003) Circ. Res. 92, 371-377) [4].
  • We recently showed that down-regulation of nucleolar protein RNA helicase II/Gualpha (RH-II/Gualpha or DDX21) in Xenopus oocytes inhibited processing of 20 S rRNA to 18 S and contributed to degradation of 28 S rRNA (Yang, H., Zhou, J., Ochs, R. L., Henning, D., Jin, R., and Valdez, B. C. (2003) J. Biol. Chem. 278, 38847-38859) [5].
  • We have previously isolated two MIN6 beta-cell sublines, B1, highly responsive to glucose-stimulated insulin secretion, and C3, markedly refractory (Lilla, V., Webb, G., Rickenbach, K., Maturana, A., Steiner, D. F., Halban, P. A. and Irminger, J. C. (2003) Endocrinology 144, 1368-1379) [6].

Biological context of 3-methyl-2-phenyl-hexanoic acid 2-diethylaminoethyl ester

  • Crucially, while it is known that the bonds between G2 and G6 are broken by co-operative occupancy of calcium binding sites in both domains [Lagarrique, E., Maciver, S. K., Fattoum, A., Benyamin, Y. & Roustan, C. (2003) Eur. J. Biochem. 270, 2236-2243.], pH values that activate gelsolin do not result in a weakening of the G2-G6 bonds [7].
  • The students submitted audio-diaries as part of a national study (Pope, R., Graham. L., Finnerty. G., Magnusson, C. 2003. An investigation of the preparation and assessment for midwifery practice within a range of settings. Project Report. University of Surrey) [8].

Gene context of 3-methyl-2-phenyl-hexanoic acid 2-diethylaminoethyl ester

  • We previously found that six residues of the yeast IF(1) (Phe17, Arg20, Glu21, Arg22, Glu25, and Phe28) form an ATPase inhibitory site [Ichikawa, N. and Ogura, C. (2003) J. Bioenerg. Biomembr. 35, 399-407] [9].


  1. Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells. Das, R., Mahabeleshwar, G.H., Kundu, G.C. J. Biol. Chem. (2004) [Pubmed]
  2. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. Dobreva, I., Waeber, G., James, R.W., Widmann, C. J. Biol. Chem. (2006) [Pubmed]
  3. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. Munir, S., Xu, G., Wu, Y., Yang, B., Lala, P.K., Peng, C. J. Biol. Chem. (2004) [Pubmed]
  4. Glucose regulates interleukin-8 production in aortic endothelial cells through activation of the p38 mitogen-activated protein kinase pathway in diabetes. Srinivasan, S., Bolick, D.T., Hatley, M.E., Natarajan, R., Reilly, K.B., Yeh, M., Chrestensen, C., Sturgill, T.W., Hedrick, C.C. J. Biol. Chem. (2004) [Pubmed]
  5. Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. Henning, D., So, R.B., Jin, R., Lau, L.F., Valdez, B.C. J. Biol. Chem. (2003) [Pubmed]
  6. Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. Tomas, A., Yermen, B., Min, L., Pessin, J.E., Halban, P.A. J. Cell. Sci. (2006) [Pubmed]
  7. The activation of gelsolin by low pH: the calcium latch is sensitive to calcium but not pH. Lagarrigue, E., Ternent, D., Maciver, S.K., Fattoum, A., Benyamin, Y., Roustan, C. Eur. J. Biochem. (2003) [Pubmed]
  8. An exploration of student midwives' language to describe non-formal learning in professional practice. Finnerty, G., Pope, R. Nurse education today. (2005) [Pubmed]
  9. Mitochondrial ATP synthase residue betaarginine-408, which interacts with the inhibitory site of regulatory protein IF1, is essential for the function of the enzyme. Ichikawa, N., Chisuwa, N., Tanase, M., Nakamura, M. J. Biochem. (2005) [Pubmed]
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