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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Endocrinology

  • We reported evidence for CaM kinase II and a synapsin I-like protein present in mouse insulinoma MIN6 cells (Matsumoto, K., Fukunaga, K., Miyazaki, J., Shichiri, M., and Miyamoto, E. (1995) Endocrinology 136, 3784-3793) [1].
  • METHODS: We reassessed the relationship between the optimal daily levothyroxine dose and the pretreatment serum thyrotropin concentration as determined by the newer assay in 192 consecutive patients with primary hypothyroidism referred to an endocrinology clinic over a period of 4 years [2].
  • High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP) [3].
  • Cardiovascular endocrinology 1: aldosterone function in diabetes mellitus: effects on cardiovascular and renal disease [4].
  • SETTING: The study took place within the Department of Endocrinology and Reproductive Medicine, Necker Hospital, Paris, France. PATIENTS: We describe eight patients with inflammatory gigantomastia, occurring in a context of immune-mediated diseases: myasthenia, chronic arthritis, or thyroiditis [5].

Psychiatry related information on Endocrinology


High impact information on Endocrinology

  • Our findings indicate that insulin, together with leptin and other neuropeptides, may modulate hypothalamic control of appetite and reproductive endocrinology [7].
  • In agreement with this wide distribution of receptors is the fact that now more than 300 separate actions of PRL have been reported in various vertebrates, including effects on water and salt balance, growth and development, endocrinology and metabolism, brain and behavior, reproduction, and immune regulation and protection [8].
  • Molecular endocrinology of hydroxysteroid dehydrogenases [9].
  • This new field of endocrinology, called intracrinology, describes the local synthesis of androgens and estrogens made locally in each cell of each peripheral tissue from the adrenal precursors DHEA and 4-dione [10].
  • Assessment of the place for GH therapy in the treatment of short stature requires special knowledge of childhood diseases, growth, and endocrinology [11].

Chemical compound and disease context of Endocrinology


Biological context of Endocrinology


Anatomical context of Endocrinology

  • Pretreatment of rat FRTL-5 thyroid cells with thyrotropin (TSH) markedly potentiated the mitogenic response to insulin-like growth factor I (IGF-I) (Tramontano, D., Moses, A. C., Veneziani, B. M., and Ingbar, S. H. (1988) Endocrinology 122, 127-132; Takahashi, S.-I., Conti, M., and Van Wyk, J. J. (1990) Endocrinology 126, 736-745) [22].
  • Pancreatic islet cells contain at least six PKC isoenzymes (Knutson, K. L., and Hoenig, M. (1994) Endocrinology 135, 881-886) [23].
  • The bovine uterus, like other estrogen-responsive organs of man and rat, synthesizes an unusual nonpolar metabolite of estradiol (Schatz, F., and Hochberg, R. B. (1981) Endocrinology 109, 697-703) [24].
  • A monoclonal antibody (MAb), designated PR-6, produced against chick oviduct progesterone receptors [Sullivan, W. P., Beito, T. G., Proper, J., Krco, C. J., & Toft, D. O. (1986) Endocrinology (Baltimore) 119, 1549-1557] cross-reacts with the Mr 120,000 human B receptors [25].
  • We recently described a better correlation of DNA synthesis with phosphatidylinositol (PI) 3-kinase than with mitogen-activated protein (MAP) kinase stimulated by insulin-like growth factor (IGF)-1 or epidermal growth factor (EGF) in human skin fibroblasts (Takahashi et al., 1997, Endocrinology 138:741-750) [26].

Associations of Endocrinology with chemical compounds

  • Murine uterine steady-state protein levels of the 90-kilodalton heat shock protein (HSP90) have been demonstrated recently to be increased by estrogen in a target tissue- and steroid-specific manner (C. Ramachandran, M.G. Catelli, W. Schneider, and G. Shyamala, Endocrinology 123:956-961, 1988) [27].
  • After graduating from the School of Technology, I started working in the Department of Medicine at Charles University in Prague as a clinical chemist in endocrinology [28].
  • The pituitary-derived bGH has been shown to be heterogeneous at the NH2 terminus (Lorenson, M. F., and Ellis, S. (1975) Endocrinology 96, 833-838), whereas the recombinant DNA-derived bGH contains a single NH2 terminus [29].
  • In this cell, norepinephrine stimulates cyclic GMP and cyclic AMP greater than 100-fold by activating both alpha 1- and beta-adrenoceptors. beta-Adrenergic activation is a requisite event and is potentiated by alpha 1-adrenergic activation (Vanecek, J., Sugden, D., Weller, J. L., and Klein, D. C. (1985) Endocrinology 116, 2167-2173) [30].
  • The calmodulin antagonist, trifluoperazine, rescues bone loss in ovariectomized mice (Zhang, L., Feng, X., and McDonald, J. M. (2003) Endocrinology 144, 4536-4543) [31].

Gene context of Endocrinology


Analytical, diagnostic and therapeutic context of Endocrinology

  • RESEARCH DESIGN AND METHODS--A prospective, blinded cross-over study was performed at the Endocrinology Clinic of a U.S. Army Medical Center on 20 volunteers with NIDDM, treated with diet alone or diet plus an oral hypoglycemic agent [37].
  • We describe a convenient and specific radioimmunoassay for urinary metanephrine, in which we used an antiserum generated in rabbits by injecting with synephrine conjugated to bovine serum albumin as described by Grota and Brown [Endocrinology 98, 615 (1976)] [38].
  • After initial purification of ovine placental lactogen (oPL) using the procedures described previously [(1976) Endocrinology 98, 65-75], the oPL preparation was further purified by high-performance liquid chromatography (HPLC) using an anionic exchange column (Bio-Sil TSK DEAE-2-SW) [39].
  • STUDY DESIGN: A longitudinal study of response to daily GH treatment (15-26 IU/m2/week) was performed in 16 singleton Caucasian prepubertal children (11 boys, 5 girls) with isolated GH insufficiency (peak GH response to insulin tolerance test <13.5 mU/L) attending a pediatric endocrinology clinic [40].
  • SETTING: Department of Reproductive Endocrinology and Infertility at the University of Vermont, College of Medicine. PATIENTS: One hundred twenty patients, all of whom had a HSG, hysteroscopy, and laparoscopy by a member of our department between 1989 and 1993 [41].


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  2. Serum thyrotropin in primary hypothyroidism. A possible predictor of optimal daily levothyroxine dose in primary hypothyroidism. Kabadi, U.M., Jackson, T. Arch. Intern. Med. (1995) [Pubmed]
  3. High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP). Massa, O., Meschi, F., Cuesta-Munoz, A., Caumo, A., Cerutti, F., Toni, S., Cherubini, V., Guazzarotti, L., Sulli, N., Matschinsky, F.M., Lorini, R., Iafusco, D., Barbetti, F. Diabetologia (2001) [Pubmed]
  4. Cardiovascular endocrinology 1: aldosterone function in diabetes mellitus: effects on cardiovascular and renal disease. McFarlane, S.I., Sowers, J.R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  5. Breast inflammatory gigantomastia in a context of immune-mediated diseases. Touraine, P., Youssef, N., Alyanakian, M.A., Lechat, X., Balleyguier, C., Duflos, C., Dib, A., May, A., Carel, J.C., Laborde, K., Sigal-Zafrani, B., Goffin, V., Eymard, B., Boitard, C., Brousse, N., Kuttenn, F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology. Goodyer, I.M., Park, R.J., Netherton, C.M., Herbert, J. The British journal of psychiatry : the journal of mental science. (2001) [Pubmed]
  7. IRS-2 pathways integrate female reproduction and energy homeostasis. Burks, D.J., Font de Mora, J., Schubert, M., Withers, D.J., Myers, M.G., Towery, H.H., Altamuro, S.L., Flint, C.L., White, M.F. Nature (2000) [Pubmed]
  8. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Bole-Feysot, C., Goffin, V., Edery, M., Binart, N., Kelly, P.A. Endocr. Rev. (1998) [Pubmed]
  9. Molecular endocrinology of hydroxysteroid dehydrogenases. Penning, T.M. Endocr. Rev. (1997) [Pubmed]
  10. DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Labrie, F., Luu-The, V., Labrie, C., Simard, J. Frontiers in neuroendocrinology. (2001) [Pubmed]
  11. Which children should have growth hormone therapy? Milner, R.D. Lancet (1986) [Pubmed]
  12. Induction of ovarian follicular cysts in the pregnant rat by human chorionic gonadotropin. Bogovich, K. Biol. Reprod. (1991) [Pubmed]
  13. Pituitary-testicular function of prostatic cancer patients during treatment with a gonadotropin-releasing hormone agonist analog. II. Endocrinology and histology of the testis. Huhtaniemi, I., Nikula, H., Parvinen, M., Rannikko, S. J. Androl. (1987) [Pubmed]
  14. Gestational outcome of clomiphene-related conceptions. Adashi, E.Y., Rock, J.A., Sapp, K.C., Martin, E.J., Wentz, A.C., Jones, G.S. Fertil. Steril. (1979) [Pubmed]
  15. A survey of dopamine agonist withdrawal policy in UK endocrinologists treating patients with prolactinomas. Clinical Endocrinology 58, 111. Wass, J., Turner, H. Clin. Endocrinol. (Oxf) (2003) [Pubmed]
  16. 1,25-Dihydroxyvitamin D3 selectively translocates PKCalpha to nuclei in ROS 17/2.8 cells. Rivera-Bermúdez, M.A., Bertics, P.J., Albrecht, R.M., Mosavin, R., Mellon, W.S. Mol. Cell. Endocrinol. (2002) [Pubmed]
  17. Galanin and galanin antagonists: molecular and biochemical perspectives. Bartfai, T., Fisone, G., Langel, U. Trends Pharmacol. Sci. (1992) [Pubmed]
  18. Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors. Muscat, G.E., Mynett-Johnson, L., Dowhan, D., Downes, M., Griggs, R. Nucleic Acids Res. (1994) [Pubmed]
  19. A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update. Waelput, W., Brouckaert, P., Broekaert, D., Tavernier, J. Current medicinal chemistry. (2006) [Pubmed]
  20. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Ehrmann, D.A., Barnes, R.B., Rosenfield, R.L., Cavaghan, M.K., Imperial, J. Diabetes Care (1999) [Pubmed]
  21. Skin reactive hyperemia in diabetic patients. A study by laser Doppler flowmetry. Tur, E., Yosipovitch, G., Bar-On, Y. Diabetes Care (1991) [Pubmed]
  22. Thyrotropin and insulin-like growth factor I regulation of tyrosine phosphorylation in FRTL-5 cells. Interaction between cAMP-dependent and growth factor-dependent signal transduction. Takahashi, S., Conti, M., Prokop, C., Van Wyk, J.J., Earp, H.S. J. Biol. Chem. (1991) [Pubmed]
  23. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. Yedovitzky, M., Mochly-Rosen, D., Johnson, J.A., Gray, M.O., Ron, D., Abramovitch, E., Cerasi, E., Nesher, R. J. Biol. Chem. (1997) [Pubmed]
  24. Estradiol fatty acid esters. The isolation and identification of the lipoidal derivative of estradiol synthesized in the bovine uterus. Mellon-Nussbaum, S.H., Ponticorvo, L., Schatz, F., Hochberg, R.B. J. Biol. Chem. (1982) [Pubmed]
  25. Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. Estes, P.A., Suba, E.J., Lawler-Heavner, J., Elashry-Stowers, D., Wei, L.L., Toft, D.O., Sullivan, W.P., Horwitz, K.B., Edwards, D.P. Biochemistry (1987) [Pubmed]
  26. Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts. Takahashi, Y., Akanuma, Y., Yazaki, Y., Kadowaki, T. J. Cell. Physiol. (1999) [Pubmed]
  27. Estrogenic regulation of murine uterine 90-kilodalton heat shock protein gene expression. Shyamala, G., Gauthier, Y., Moore, S.K., Catelli, M.G., Ullrich, S.J. Mol. Cell. Biol. (1989) [Pubmed]
  28. Rough and rocky road to the retinoid revolution. Chytil, F. Annu. Rev. Nutr. (2003) [Pubmed]
  29. The kinetics of bovine growth hormone folding are consistent with a framework model. Brems, D.N., Plaisted, S.M., Dougherty, J.J., Holzman, T.F. J. Biol. Chem. (1987) [Pubmed]
  30. A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes. Sugden, D., Klein, D.C. J. Biol. Chem. (1987) [Pubmed]
  31. Fas binding to calmodulin regulates apoptosis in osteoclasts. Wu, X., Ahn, E.Y., McKenna, M.A., Yeo, H., McDonald, J.M. J. Biol. Chem. (2005) [Pubmed]
  32. CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency. Joehrer, K., Geley, S., Strasser-Wozak, E.M., Azziz, R., Wollmann, H.A., Schmitt, K., Kofler, R., White, P.C. Hum. Mol. Genet. (1997) [Pubmed]
  33. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. Oh, Y., Müller, H.L., Lamson, G., Rosenfeld, R.G. J. Biol. Chem. (1993) [Pubmed]
  34. Uterine endocrinology and paracrinology: insulin-like growth factor binding protein-1 and placental protein 14 revisited. Seppälä, M., Koistinen, R., Rutanen, E.M. Hum. Reprod. (1994) [Pubmed]
  35. Somatostatin and cancer: applying endocrinology to oncology. Grimberg, A. Cancer Biol. Ther. (2004) [Pubmed]
  36. Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide. Meier, J.J., Nauck, M.A. Best practice & research. Clinical endocrinology & metabolism. (2004) [Pubmed]
  37. Effect of cold remedies on metabolic control of NIDDM. LeMar, H.J., Georgitis, W.J. Diabetes Care (1993) [Pubmed]
  38. Radioimmunoassay for free and conjugated urinary metanephrine. Lam, R.W., Artal, R., Fisher, D.A. Clin. Chem. (1977) [Pubmed]
  39. Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography. Evidence for two forms of oPL. Chan, J.S., Nie, Z.R., Seidah, N.G., Chrétien, M. FEBS Lett. (1986) [Pubmed]
  40. Birth weight influences the initial response to growth hormone treatment in growth hormone-insufficient children. Achermann, J.C., Hamdani, K., Hindmarsh, P.C., Brook, C.G. Pediatrics (1998) [Pubmed]
  41. The association of intrauterine filling defects on hysterosalpingogram with endometriosis. McBean, J.H., Gibson, M., Brumsted, J.R. Fertil. Steril. (1996) [Pubmed]
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