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Chemical Compound Review

AC1NUYXT     2-amino-1-hydroxy-guanidine

Synonyms: HSCI1_000240, 2-amino-1-hydroxyguanidine
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Disease relevance of N-Hydroxy-N'-aminoguanidine


High impact information on N-Hydroxy-N'-aminoguanidine


Biological context of N-Hydroxy-N'-aminoguanidine


Associations of N-Hydroxy-N'-aminoguanidine with other chemical compounds


  1. Design, synthesis, testing, and quantitative structure-activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus. Wang, P.H., Keck, J.G., Lien, E.J., Lai, M.M. J. Med. Chem. (1990) [Pubmed]
  2. Inhibition of ribonucleotide reductase and growth of human colon carcinoma HT-29 cells and mouse leukemia L1210 cells by N-hydroxy-N'-aminoguanidine derivatives. Matsumoto, M., Fox, J.G., Wang, P.H., Koneru, P.B., Lien, E.J., Cory, J.G. Biochem. Pharmacol. (1990) [Pubmed]
  3. Quantitative structure-activity relationship (QSAR) analysis of the cytotoxicities of aminohydroxyguanidine derivatives and their antiviral activities in vitro. Wang, P.H., Hui, M.B., Nandy, P., Banerjee, S., Gao, H., Lien, E.J. Pharm. Res. (1991) [Pubmed]
  4. Effects of N-hydroxy-N'-aminoguanidine derivatives on ribonucleotide reductase activity, nucleic acid synthesis, clonogenicity, and cell cycle of L1210 cells. Weckbecker, G., Weckbecker, A., Lien, E.J., Cory, J.G. Cancer Res. (1987) [Pubmed]
  5. Studies of N-hydroxy-N'-aminoguanidine derivatives by nitrogen-15 nuclear magnetic resonance spectroscopy and as ribonucleotide reductase inhibitors. Tai, A.W., Lien, E.J., Moore, E.C., Chun, Y., Roberts, J.D. J. Med. Chem. (1983) [Pubmed]
  6. Synthesis and testing of new antileukemic Schiff bases of N-hydroxy-N'-aminoguanidine against CCRF-CEM/0 human leukemia cells in vitro and synergism studies with cytarabine (Ara-C). Koneru, P.B., Lien, E.J., Avramis, V.I. Pharm. Res. (1993) [Pubmed]
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