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Chemical Compound Review

Nitrogen-15     azane

Synonyms: Ammonia-15N, AC1L32GY, 299227_ALDRICH, 487953_ALDRICH, 13767-16-3, ...
 
 
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Disease relevance of ammonia

  • The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel [1].
  • The resultant ammonia toxicity might exacerbate the neurological deficits of HD [2].
  • Nitrogen 15 tracer studies on the pathway of denitrification in Pseudomonas aeruginosa [3].
  • The dynamic properties of ribosomal protein L9 from Bacillus stearothermophilus were investigated in solution using an analysis of nitrogen-15 longitudinal and transverse relaxation rates and amide nitrogen-proton nuclear Overhauser effects [4].
  • d-Amino acid amidase (DAA) from Ochrobactrum anthropi SV3, which catalyzes the stereospecific hydrolysis of d-amino acid amides to yield the d-amino acid and ammonia, has attracted increasing attention as a catalyst for the stereospecific production of d-amino acids [5].
 

Psychiatry related information on ammonia

  • In anorexia nervosa patients, biochemical abnormalities in the serum were more frequent in total serum protein (93%), blood sugar (85%), and globulins (78%) than in other serum factors, such as blood urea nitrogen (15%), uric acid (15%), and alkaline phosphatase (7%) [6].
 

High impact information on ammonia

  • In Escherichia coli, previous studies have indicated that binding of the P(II) signal transduction protein GlnK to the ammonia channel AmtB regulates the channel thereby controlling ammonium influx in response to the intracellular nitrogen status [1].
  • The dependence of T1 and nuclear Overhauser effects upon correlation time is discussed, and preliminary nitrogen-15 nuclear magnetic resonance results for several biopolymers, including lysozyme, protamines, pepsin, hemoglobin, vitamin B 12, and tRNA, are presented [7].
  • Microglia also degrade fAbeta if lysosomes are acidified by an ammonia pulse-wash or by treatment with forskolin, which activates protein kinase A. Our results indicate that regulated lysosomal acidification can potentiate fAbeta degradation by microglia [8].
  • Detailed nitrogen-15 relaxation measurements indicate that Ca2+ may facilitate the adaptive recognition of the substrate by inducing slow micro- to millisecond time-scale dynamics in the active site [9].
  • 0. Only an averaged azide signal was observed in the nitrogen-15 NMR spectra for solutions that contained the azide complex of chloroperoxidase, horseradish peroxidase, and myoglobin [10].
 

Chemical compound and disease context of ammonia

 

Biological context of ammonia

 

Anatomical context of ammonia

 

Associations of ammonia with other chemical compounds

 

Gene context of ammonia

  • In this study, we investigated the pH titration behavior of the carboxyl groups of the N-terminal domain of rat CD2 (CD2d1) using the chemical shifts of backbone amide nitrogen-15 ((15)N) and proton NMR resonances, and carboxyl carbon-13 ((13)C) signals [29].
  • Significant within-group differences were found for the PLC group: CORT before compared with immediately after exercise; INS before compared with immediately after exercise and before compared with 1.5 hours after exercise; and AMM before compared with immediately after exercise and before compared with 1.5 hours after exercise [30].
  • Analysis of the hyperfine-shifted nitrogen-15 resonances of the oxidized form of Anabaena 7120 heterocyst ferredoxin [31].
  • Multinuclear magnetic resonance studies of the 2Fe.2S* ferredoxin from Anabaena species strain PCC 7120. 3. Detection and characterization of hyperfine-shifted nitrogen-15 and hydrogen-1 resonances of the oxidized form [32].
  • Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase [33].
 

Analytical, diagnostic and therapeutic context of ammonia

  • The dynamic aspects of protein metabolism in uremic children were studied by using newly developed gas chromatography and mass spectrometry micromethods for determining nitrogen-15 enrichment in plasma lysine during a continuous i.v. infusion of 15N-lysine [34].
  • This organ is responsible for most of the excretory processes (ultrafiltration, reabsorption and secretion) and secretes an acidic ammonia-rich excretory fluid [35].
  • The quantitative determinations have been carried out by selective titrations in aqueous solutions, thermal programmed desorption connected to mass spectrometry (TPD-MS), and ammonia adsorption-desorption, measured by thermogravimetry (TG) [36].
  • A sequential upflow anaerobic sludge blanket (UASB) and air-lift loop sludge blanket (ALSB) treatment was introduced into leachate recirculation to remove organic matter and ammonia from leachate in a lab-scale bioreactor landfill [37].
  • Treatment of chromomycosis by cryosurgery with liquid nitrogen: 15 years' experience [38].

References

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  2. Dysregulation of C/EBP{alpha} by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. Chiang, M.C., Chen, H.M., Lee, Y.H., Chang, H.H., Wu, Y.C., Soong, B.W., Chen, C.M., Wu, Y.R., Liu, C.S., Niu, D.M., Wu, J.Y., Chen, Y.T., Chern, Y. Hum. Mol. Genet. (2007) [Pubmed]
  3. Nitrogen 15 tracer studies on the pathway of denitrification in Pseudomonas aeruginosa. St John, R.T., Hollocher, T.C. J. Biol. Chem. (1977) [Pubmed]
  4. An investigation of the dynamics of ribosomal protein L9 using heteronuclear NMR relaxation measurements. Lillemoen, J., Hoffman, D.W. J. Mol. Biol. (1998) [Pubmed]
  5. Crystal Structure and Functional Characterization of a D-Stereospecific Amino Acid Amidase from Ochrobactrum anthropi SV3, a New Member of the Penicillin-recognizing Proteins. Okazaki, S., Suzuki, A., Komeda, H., Yamaguchi, S., Asano, Y., Yamane, T. J. Mol. Biol. (2007) [Pubmed]
  6. Biochemical abnormalities of the serum in anorexia nervosa. Umeki, S. J. Nerv. Ment. Dis. (1988) [Pubmed]
  7. Applications of natural-abundance nitrogen-15 nuclear magnetic resonance to large biochemically important molecules. Gust, D., Moon, R.B., Roberts, J.D. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  8. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., Maxfield, F.R. Mol. Biol. Cell (2007) [Pubmed]
  9. Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop. Naik, M.T., Suree, N., Ilangovan, U., Liew, C.K., Thieu, W., Campbell, D.O., Clemens, J.J., Jung, M.E., Clubb, R.T. J. Biol. Chem. (2006) [Pubmed]
  10. Proton and nitrogen-15 NMR spectroscopic studies of hydrogen ion-dependent pseudo-halide ion binding to chloroperoxidase. Lukat, G.S., Goff, H.M. J. Biol. Chem. (1986) [Pubmed]
  11. Assignment of the three methionyl carbonyl carbon resonances in Streptomyces subtilisin inhibitor by a carbon-13 and nitrogen-15 double-labeling technique. A new strategy for structural studies of proteins in solution. Kainosho, M., Tsuji, T. Biochemistry (1982) [Pubmed]
  12. NMR study of nitrogen-15-labeled Escherichia coli valine transfer RNA. Choi, B.S., Redfield, A.G. Biochemistry (1992) [Pubmed]
  13. Suitability of biocompost as a bedding material for stabled horses: respiratory hygiene and management practicalities. Seedorf, J., Schröder, M., Köhler, L., Hartung, J. Equine Vet. J. (2007) [Pubmed]
  14. The structure of the core-O-chain linkage region of the lipopolysaccharide from Bordetella hinzii. Vinogradov, E. Carbohydr. Res. (2007) [Pubmed]
  15. Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR. Paul, L., Mishra, P.K., Blumenthal, R.M., Matthews, R.G. BMC Microbiol. (2007) [Pubmed]
  16. Hydrogen exchange in unligated and ligated staphylococcal nuclease. Loh, S.N., Prehoda, K.E., Wang, J., Markley, J.L. Biochemistry (1993) [Pubmed]
  17. Human type-alpha transforming growth factor undergoes slow conformational exchange between multiple backbone conformations as characterized by nitrogen-15 relaxation measurements. Li, Y.C., Montelione, G.T. Biochemistry (1995) [Pubmed]
  18. Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices. Reinehr, R., Görg, B., Becker, S., Qvartskhava, N., Bidmon, H.J., Selbach, O., Haas, H.L., Schliess, F., Häussinger, D. Glia (2007) [Pubmed]
  19. A Novel Deaminase Involved in Chloronitrobenzene and Nitrobenzene Degradation with Comamonas sp. Strain CNB-1. Liu, L., Wu, J.F., Ma, Y.F., Wang, S.Y., Zhao, G.P., Liu, S.J. J. Bacteriol. (2007) [Pubmed]
  20. Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25. Ellingson, W.J., Chesser, D.G., Winder, W.W. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  21. From Gene to HSQC in under Five Hours: High-Throughput NMR Proteomics. Keppetipola, S., Kudlicki, W., Nguyen, B.D., Meng, X., Donovan, K.J., Shaka, A.J. J. Am. Chem. Soc. (2006) [Pubmed]
  22. NMR exchange broadening arising from specific low affinity protein self-association: analysis of nitrogen-15 nuclear relaxation for rat CD2 domain 1. Pfuhl, M., Chen, H.A., Kristensen, S.M., Driscoll, P.C. J. Biomol. NMR (1999) [Pubmed]
  23. Comparative in vivo nitrogen-15 nuclear magnetic resonance study of the cell wall components of five Gram-positive bacteria. Lapidot, A., Irving, C.S. Biochemistry (1979) [Pubmed]
  24. Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2. Mavri-Damelin, D., Eaton, S., Damelin, L.H., Rees, M., Hodgson, H.J., Selden, C. Int. J. Biochem. Cell Biol. (2007) [Pubmed]
  25. Highly selective excitation in biomolecular NMR by frequency-switched single-transition cross-polarization. Ferrage, F., Eykyn, T.R., Bodenhausen, G. J. Am. Chem. Soc. (2002) [Pubmed]
  26. The nitrogen-15 magnetic resonance of glycine. Leipert, T.K., Noggle, J.H. J. Am. Chem. Soc. (1975) [Pubmed]
  27. Investigation of proton transport tautomerism in clusters of protonated nucleic acid bases (cytosine, uracil, thymine, and adenine) and ammonia by high-pressure mass spectrometry and ab initio calculations. Wu, R., McMahon, T.B. J. Am. Chem. Soc. (2007) [Pubmed]
  28. Protonation States of Ammonia/Ammonium in the Hydrophobic Pore of Ammonia Transporter Protein AmtB. Ishikita, H., Knapp, E.W. J. Am. Chem. Soc. (2007) [Pubmed]
  29. Determination of pK(a) values of carboxyl groups in the N-terminal domain of rat CD2: anomalous pK(a) of a glutamate on the ligand-binding surface. Chen, H.A., Pfuhl, M., McAlister, M.S., Driscoll, P.C. Biochemistry (2000) [Pubmed]
  30. Effects of liquid carbohydrate ingestion on markers of anabolism following high-intensity resistance exercise. Thyfault, J.P., Carper, M.J., Richmond, S.R., Hulver, M.W., Potteiger, J.A. Journal of strength and conditioning research / National Strength & Conditioning Association. (2004) [Pubmed]
  31. Analysis of the hyperfine-shifted nitrogen-15 resonances of the oxidized form of Anabaena 7120 heterocyst ferredoxin. Chae, Y.K., Markley, J.L. Biochemistry (1995) [Pubmed]
  32. Multinuclear magnetic resonance studies of the 2Fe.2S* ferredoxin from Anabaena species strain PCC 7120. 3. Detection and characterization of hyperfine-shifted nitrogen-15 and hydrogen-1 resonances of the oxidized form. Oh, B.H., Markley, J.L. Biochemistry (1990) [Pubmed]
  33. Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase. Weiss, P.M., Cook, P.F., Hermes, J.D., Cleland, W.W. Biochemistry (1987) [Pubmed]
  34. Effects of dietary intake and hemodialysis on protein turnover in uremic children. Conley, S.B., Rose, G.M., Robson, A.M., Bier, D.M. Kidney Int. (1980) [Pubmed]
  35. Enigmatic dual symbiosis in the excretory organ of Nautilus macromphalus (Cephalopoda: Nautiloidea). Pernice, M., Wetzel, S., Gros, O., Boucher-Rodoni, R., Dubilier, N. Proc. Biol. Sci. (2007) [Pubmed]
  36. On the characterization of chemical surface groups of carbon materials. Domingo-García, M., López Garzón, F.J., Pérez-Mendoza, M.J. Journal of colloid and interface science (2002) [Pubmed]
  37. Characteristics of the bioreactor landfill system using an anaerobic-aerobic process for nitrogen removal. He, R., Liu, X.W., Zhang, Z.J., Shen, D.S. Bioresour. Technol. (2007) [Pubmed]
  38. Treatment of chromomycosis by cryosurgery with liquid nitrogen: 15 years' experience. Castro, L.G., Pimentel, E.R., Lacaz, C.S. International journal of dermatology. (2003) [Pubmed]
 
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