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Chemical Compound Review

SureCN1697156     [(1-oxonaphthalen-2- ylidene)amino]urea

Synonyms: AC1NUZ4A, [(Z)-(1-oxonaphthalen-2-ylidene)amino]urea
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Disease relevance of Mediaven


High impact information on Mediaven


Biological context of Mediaven

  • Rats were also treated intraperitoneally for five days with various naftazone doses (0.125-10 mg kg-1) and ex-vivo platelet aggregation compared, at various times after the last injection, with that of control animals [2].

Anatomical context of Mediaven

  • In-vitro and ex-vivo inhibition of blood platelet aggregation by naftazone [2].
  • The pharmacological and biochemical effects of naftazone, a lysosomal membrane stabilizer and indomethacin, a standard anti-inflammatory agent were evaluated with regard to paw oedema volume, serum and exudate activities of the lysosomal enzyme N-acetyl-beta-D-glucosaminidase (NAG), in addition to serum and liver lipid peroxide (LP) levels [4].

Associations of Mediaven with other chemical compounds

  • Thrombin-induced aggregation in PRP and washed platelets was significantly reduced after in-vivo treatment with ticlopidine and naftazone [2].

Analytical, diagnostic and therapeutic context of Mediaven

  • Haemodynamic values were measured either before and 10 min after intravenous administration of 432 microg/kg of naftazone or after 4 days of oral administration of 10 mg/kg per day [1].


  1. Acute and chronic haemodynamic effects of naftazone in portal hypertensive rats. Sogni, P., Yang, S., Pilette, C., Moreau, R., Gadano, A., Avenard, G., Bloy, C., Lebrec, D. Eur. J. Pharmacol. (1998) [Pubmed]
  2. In-vitro and ex-vivo inhibition of blood platelet aggregation by naftazone. Durand, P., Bloy, C., Peltier-Pujol, F., Blache, D. J. Pharm. Pharmacol. (1996) [Pubmed]
  3. Reduction and glucuronidation of naftazone by human and rat liver microsomes. Herber, R., Hercelin, B., Van Cantfort, J., De Graeve, J., Fournel-Gigleux, S., Taguchi, T., Magdalou, J. Drug Metab. Dispos. (1995) [Pubmed]
  4. Lipid peroxidation and lysosomal integrity in different inflammatory models in rats: the effects of indomethacin and naftazone. Agha, A.M., Gad, M.Z. Pharmacol. Res. (1995) [Pubmed]
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