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Chemical Compound Review:

SureCN1697156 [(1-oxonaphthalen-2- ylidene)amino]urea

Synonyms: AC1NUZ4A, [(Z)-(1-oxonaphthalen-2-ylidene)amino]urea

Durand, P. et al., Sogni, P. et al., Agha, A.M. et al., Herber, R. et al.

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Disease relevance of Mediaven

The aim of this study was to evaluate the haemodynamic effects of acute and chronic administration of naftazone in rats with portal hypertension [1].
Oral administration of naftazone significantly decreased portal pressure in rats with portal vein stenosis; this decrease depended on a significant reduction of portal blood flow [1].
Because of the considerable interest in the role of platelets and antiplatelet therapy in cardiovascular disease, including the aggregation of platelets to each other during arterial thrombosis and atherogenesis, we have studied the effect of naftazone (Etioven), an original vasculotropic drug on platelet aggregation [2].

High impact information on Mediaven

Acute administration of naftazone significantly reduced portal pressure in portal vein-stenosed and cirrhotic rats [1].
Reduction and glucuronidation of naftazone by human and rat liver microsomes [3].
Reduction and glucuronidation of the vasoprotectant drug, naftazone, by human and rat liver microsomes and by recombinant UDP-glucuronosyltransferases (UGT) stably expressed in V79 cells were studied [3].
We conclude that naftazone inhibits platelet aggregation in-vitro and ex-vivo [2].
Inhibition by naftazone was dose-dependent in both PRP and isolated platelets [2].

Biological context of Mediaven

Rats were also treated intraperitoneally for five days with various naftazone doses (0.125-10 mg kg-1) and ex-vivo platelet aggregation compared, at various times after the last injection, with that of control animals [2].

Anatomical context of Mediaven

In-vitro and ex-vivo inhibition of blood platelet aggregation by naftazone [2].
The pharmacological and biochemical effects of naftazone, a lysosomal membrane stabilizer and indomethacin, a standard anti-inflammatory agent were evaluated with regard to paw oedema volume, serum and exudate activities of the lysosomal enzyme N-acetyl-beta-D-glucosaminidase (NAG), in addition to serum and liver lipid peroxide (LP) levels [4].

Associations of Mediaven with other chemical compounds

Thrombin-induced aggregation in PRP and washed platelets was significantly reduced after in-vivo treatment with ticlopidine and naftazone [2].

Analytical, diagnostic and therapeutic context of Mediaven

Haemodynamic values were measured either before and 10 min after intravenous administration of 432 microg/kg of naftazone or after 4 days of oral administration of 10 mg/kg per day [1].

References

Acute and chronic haemodynamic effects of naftazone in portal hypertensive rats. Sogni, P., Yang, S., Pilette, C., Moreau, R., Gadano, A., Avenard, G., Bloy, C., Lebrec, D. Eur. J. Pharmacol. (1998) [Pubmed]
In-vitro and ex-vivo inhibition of blood platelet aggregation by naftazone. Durand, P., Bloy, C., Peltier-Pujol, F., Blache, D. J. Pharm. Pharmacol. (1996) [Pubmed]
Reduction and glucuronidation of naftazone by human and rat liver microsomes. Herber, R., Hercelin, B., Van Cantfort, J., De Graeve, J., Fournel-Gigleux, S., Taguchi, T., Magdalou, J. Drug Metab. Dispos. (1995) [Pubmed]
Lipid peroxidation and lysosomal integrity in different inflammatory models in rats: the effects of indomethacin and naftazone. Agha, A.M., Gad, M.Z. Pharmacol. Res. (1995) [Pubmed]

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