The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Portal Pressure

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Portal Pressure


High impact information on Portal Pressure


Chemical compound and disease context of Portal Pressure


Biological context of Portal Pressure

  • Furthermore, ICI 118551 selective beta 2-adrenergic blockade offers portal blood flow and portal pressure reduction independent of reduction in cardiac output, which could be uniquely advantageous in situations where impairment of cardiac compensatory mechanisms might prove deleterious [14].
  • ANP at physiological concentrations reduced both PE-induced increases of portal pressure in a dose-dependent fashion, reaching half-maximal effects around 20 pmol/L and maximal effects (about 50% inhibition of PE-induced vasoconstriction) at 40 pmol/L [15].
  • STARTING POINT: David Patch and colleagues (Gastroenterology 2002; 123: 1013-19) randomised 102 patients surviving a variceal bleeding to EBL or drug therapy with propranolol with the addition of ISMN if target reductions in portal pressure (evaluated by the hepatic venous pressure-gradient [HVPG]) were not achieved at 3 months [16].
  • In sham-operated rats, clonidine reduced portal pressure presumably by decreasing hepatic portal vascular resistance, since no significant change in portal tributary blood flow was observed [17].
  • The hepatic venous pressure gradient, used as an index of portal pressure, significantly decreased after ketanserin (-23%) [18].

Anatomical context of Portal Pressure


Associations of Portal Pressure with chemical compounds


Gene context of Portal Pressure

  • The purpose of the present study was to assess the correlation that likely exists among increased portal pressure (Pp), portal blood flow quantity (Qp) and ETA and ETB receptor mRNA expression in human cirrhosis [28].
  • Endothelin A receptor blockade was not associated with significant changes in arterial and portal pressure in any group of animals [3].
  • Endothelin-stimulated contraction of stellate cells in cirrhotic liver may contribute to increased intrahepatic resistance and portal pressure [29].
  • Sarafotoxin S6C, an endothelin B (ETB) receptor agonist, had minor effects on portal pressure when perfused into normal livers at concentrations known to elicit stellate cell contraction (2 nmol/L) [29].
  • This study evaluates the acute effects of albumin dialysis, using the Molecular Adsorbents Recirculating System (MARS), on portal pressure in AH [30].

Analytical, diagnostic and therapeutic context of Portal Pressure


  1. Reduction of portal pressure by isosorbide-5-mononitrate in patients with cirrhosis. Effects on splanchnic and systemic hemodynamics and liver function. Navasa, M., Chesta, J., Bosch, J., Rodés, J. Gastroenterology (1989) [Pubmed]
  2. The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices. Escorsell, A., Ferayorni, L., Bosch, J., García-Pagán, J.C., García-Tsao, G., Grace, N.D., Rodés, J., Groszmann, R.J. Gastroenterology (1997) [Pubmed]
  3. Endothelin 1 does not play a major role in the homeostasis of arterial pressure in cirrhotic rats with ascites. Leivas, A., Jiménez, W., Lamas, S., Bosch-Marcé, M., Oriola, J., Clària, J., Arroyo, V., Rivera, F., Rodés, J. Gastroenterology (1995) [Pubmed]
  4. Propranolol plus prazosin compared with propranolol plus isosorbide-5-mononitrate in the treatment of portal hypertension. Albillos, A., García-Pagán, J.C., Iborra, J., Bandi, J.C., Cacho, G., Pérez-Paramo, M., Escorsell, A., Calleja, J.L., Escartín, P., Bosch, J. Gastroenterology (1998) [Pubmed]
  5. Bacterial infection in the pathogenesis of variceal bleeding. Goulis, J., Patch, D., Burroughs, A.K. Lancet (1999) [Pubmed]
  6. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Liu, S., Premont, R.T., Kontos, C.D., Zhu, S., Rockey, D.C. Nat. Med. (2005) [Pubmed]
  7. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. Shah, V., Haddad, F.G., Garcia-Cardena, G., Frangos, J.A., Mennone, A., Groszmann, R.J., Sessa, W.C. J. Clin. Invest. (1997) [Pubmed]
  8. Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver. Oshita, M., Takei, Y., Kawano, S., Yoshihara, H., Hijioka, T., Fukui, H., Goto, M., Masuda, E., Nishimura, Y., Fusamoto, H. J. Clin. Invest. (1993) [Pubmed]
  9. Discussion on randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis. Castaño, G., Viudez, P., Frider, B., Sookoian, S., Gustavo, C., Pedro, V., Bernardo, F., Silvia, S. Gastroenterology (2002) [Pubmed]
  10. The effects of ethanol administration on portal pressure and gastroesophageal collateral blood flow in patients with alcoholic cirrhosis. Ready, J.B., Hossack, K.F., Rector, W.G. Hepatology (1990) [Pubmed]
  11. Low dose of nitroglycerin failed to improve splanchnic hemodynamics in patients with cirrhosis: evidence for an impaired cardiopulmonary baroreflex function. Moreau, R., Roulot, D., Braillon, A., Gaudin, C., Hadengue, A., Bacq, Y., Lebrec, D. Hepatology (1989) [Pubmed]
  12. Comparison of the hemodynamic responses to ketanserin and prazosin in portal hypertensive rats. Cummings, S.A., Kaumann, A.J., Groszmann, R.J. Hepatology (1988) [Pubmed]
  13. Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis. Bellis, L., Berzigotti, A., Abraldes, J.G., Moitinho, E., García-Pagán, J.C., Bosch, J., Rodés, J. Hepatology (2003) [Pubmed]
  14. Effect of selective blockade of beta 2-adrenergic receptors on portal and systemic hemodynamics in a portal hypertensive rat model. Kroeger, R.J., Groszmann, R.J. Gastroenterology (1985) [Pubmed]
  15. Prolonged antagonism of alpha 1-adrenergic vasoconstriction in the rat liver by atrial natriuretic peptide. Bilzer, M., Paumgartner, G., Gerbes, A.L. Gastroenterology (1995) [Pubmed]
  16. Prevention of variceal rebleeding. Bosch, J., García-Pagán, J.C. Lancet (2003) [Pubmed]
  17. Mechanisms of a clonidine-induced decrease in portal pressure in normal and cirrhotic conscious rats. Roulot, D., Braillon, A., Gaudin, C., Ozier, Y., Girod, C., Lebrec, D. Hepatology (1989) [Pubmed]
  18. Beneficial hemodynamic effects of ketanserin in patients with cirrhosis: possible role of serotonergic mechanisms in portal hypertension. Hadengue, A., Lee, S.S., Moreau, R., Braillon, A., Lebrec, D. Hepatology (1987) [Pubmed]
  19. Effects of ritanserin, a selective and specific S2-serotonergic antagonist, on portal pressure and splanchnic hemodynamics in rats with long-term bile duct ligation. Fernández, M., Pizcueta, P., García-Pagán, J.C., Feu, F., Cirera, I., Bosch, J., Rodés, J. Hepatology (1993) [Pubmed]
  20. Noninvasive hemodynamic measurements of superior mesenteric artery in the prediction of portal pressure response to propranolol. Iwao, T., Oho, K., Sakai, T., Sato, M., Nakano, R., Yamayaki, M., Toyonaga, A., Tanikawa, K. J. Hepatol. (1998) [Pubmed]
  21. Alpha-adrenoceptor antagonistic action of amiloride. Häussinger, D., Brodde, O.E., Starke, K. Biochem. Pharmacol. (1987) [Pubmed]
  22. Hypersensitivity of mesenteric veins to 5-hydroxytryptamine- and ketanserin-induced reduction of portal pressure in portal hypertensive rats. Cummings, S.A., Groszmann, R.J., Kaumann, A.J. Br. J. Pharmacol. (1986) [Pubmed]
  23. Role of thromboxane A2 in early BDL-induced portal hypertension. Yokoyama, Y., Xu, H., Kresge, N., Keller, S., Sarmadi, A.H., Baveja, R., Clemens, M.G., Zhang, J.X. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  24. Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension. Sarin, S.K., Groszmann, R.J., Mosca, P.G., Rojkind, M., Stadecker, M.J., Bhatnagar, R., Reuben, A., Dayal, Y. J. Clin. Invest. (1991) [Pubmed]
  25. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver. Reichen, J., Le, M. J. Clin. Invest. (1986) [Pubmed]
  26. Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension. Escorsell , A., Bandi, J.C., Andreu, V., Moitinho, E., García-Pagán, J.C., Bosch, J., Rodés, J. Gastroenterology (2001) [Pubmed]
  27. Effects of vasopressin on portal pressure during hemorrhage from esophageal varices. Ready, J.B., Robertson, A.D., Rector, W.G. Gastroenterology (1991) [Pubmed]
  28. Increased expression of endothelin receptors in human cirrhosis--relationship with splanchnic hemodynamics. Deng, X., Yang, Z. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2002) [Pubmed]
  29. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Rockey, D.C., Weisiger, R.A. Hepatology (1996) [Pubmed]
  30. Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis. Sen, S., Mookerjee, R.P., Cheshire, L.M., Davies, N.A., Williams, R., Jalan, R. J. Hepatol. (2005) [Pubmed]
  31. Continuous prazosin administration in cirrhotic patients: effects on portal hemodynamics and on liver and renal function. Albillos, A., Lledó, J.L., Rossi, I., Pérez-Páramo, M., Tabuenca, M.J., Bañares, R., Iborra, J., Garrido, A., Escartín, P., Bosch, J. Gastroenterology (1995) [Pubmed]
  32. Chronic blockade of endothelin receptors in cirrhotic rats: hepatic and hemodynamic effects. Poo, J.L., Jiménez, W., María Muñoz, R., Bosch-Marcé, M., Bordas, N., Morales-Ruiz, M., Pérez, M., Deulofeu, R., Solé, M., Arroyo, V., Rodés, J. Gastroenterology (1999) [Pubmed]
  33. Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats. Fort, J., Oberti, F., Pilette, C., Veal, N., Gallois, Y., Douay, O., Rousselet, M.C., Rosenbaum, J., Calès, P. Hepatology (1998) [Pubmed]
  34. Isosorbide dinitrate in experimental portal hypertension: a study of factors that modulate the hemodynamic response. Blei, A.T., Gottstein, J. Hepatology (1986) [Pubmed]
  35. Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Transjugular intrahepatic portosystemic shunt. Bellis, L., Moitinho, E., Abraldes, J.G., Graupera, M., García-Pagán, J.C., Rodés, J., Bosch, J. Gut (2003) [Pubmed]
WikiGenes - Universities