Disease relevance of Kryptocyanine

• Phototoxicity mechanism of a kryptocyanine dye in human red cell membranes and isolated murine mitochondria [1].

High impact information on Kryptocyanine

• Cryptocyanin, a crustacean molting protein: evolutionary link with arthropod hemocyanins and insect hexamerins [2].
• Cryptocyanin has no phenoloxidase activity, although a phenoloxidase is present in the hemolymph [2].
• The concentration of cryptocyanin in the hemolymph is closely coordinated with the molt cycle and reaches levels higher than hemocyanin during premolt [2].
• Phylogenetic analysis of sequence similarities between cryptocyanin and other members of the hemocyanin gene family shows that cryptocyanin is closely associated with crustacean hemocyanins and suggests that cryptocyanin arose as a result of a hemocyanin gene duplication [2].
• The phototoxicity mechanism of a kryptocyanine dye, N,N'-bis(2-ethyl-1,3-dioxolane)kryptocyanine (EDKC+), has been studied in RBC membranes and isolated mitochondria [1].

Anatomical context of Kryptocyanine

• Both proteins are specifically expressed in the same type of cell in the hepatopancreas and secreted into the hemolymph, but cryptocyanin plays a major role in forming the new exoskeleton, while hemocyanin functions in oxygen transport [3].

Associations of Kryptocyanine with other chemical compounds

• The photophysical properties of 1,1'-diethyl-4,4'-carbocyanine chloride (kryptocyanine) have been measured in methanol solution and for the dye bound to human serum albumin, incorporated in neutral micelles and after incubation with leukemia cells [4].

Gene context of Kryptocyanine

• Cryptocyanin resembles insect hexamerins in the lack of copper, molt cycle patterns of biosynthesis, and potential contributions to the new exoskeleton [2].

References