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Chemical Compound Review

proscillaridin     5-[(3S,10R,13R,14S,17S)-14- hydroxy-10,13...

Synonyms: Talucard, Tradenal, Herzo, KST-1A5060, AC1L1UFN, ...
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Disease relevance of Talusin


High impact information on Talusin

  • The experiments in conjunction with the previous finding of the appearance of vesicles in vacuoles of starved cells (Simeon, A., van der Klei, I.J., Veenhuis, M., and Wolf, D. H. (1992) FEBS Lett. 301, 231-235) indicate that transport of these tested cytoplasmic proteins into the vacuole is an unselective bulk process induced by nutritional stress [4].
  • The concentration of the proscillaridin A immunoreactivity ED1 in normotensive subjects had a geometric mean of 0.1 nmol/L, with a dispersion factor of 8.77 [5].
  • We conclude that several substances cross-reacting with proscillaridin A antibodies and inhibiting the sodium pump of human red blood cells circulate in human blood [5].
  • IgG had an apparent affinity of 2 x 10(-9) mol/L for proscillaridin A [5].
  • To test whether bufadienolide-like substances may circulate in human blood, we used antibodies from rabbits against the bufadienolide proscillaridin A to measure the concentration of cross-reacting material in human plasma with an indirect enzyme-linked immunosorbent assay [5].

Chemical compound and disease context of Talusin


Biological context of Talusin


Anatomical context of Talusin


Associations of Talusin with other chemical compounds


Gene context of Talusin

  • In a separate experiment, the oxime TMB-4.2Br (100 microM), which did not inhibit AChE, increased the inhibitory effect of proscillaridin from 4% to 11% (a 3.7-fold increase) [15].

Analytical, diagnostic and therapeutic context of Talusin


  1. Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. Schneider, R., Wray, V., Nimtz, M., Lehmann, W.D., Kirch, U., Antolovic, R., Schoner, W. J. Biol. Chem. (1998) [Pubmed]
  2. Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. Bielawski, K., Winnicka, K., Bielawska, A. Biol. Pharm. Bull. (2006) [Pubmed]
  3. Disposition rate of proscillaridin A in man after multiple oral doses. Bergdahl, B. Arzneimittel-Forschung. (1979) [Pubmed]
  4. Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae. Egner, R., Thumm, M., Straub, M., Simeon, A., Schüller, H.J., Wolf, D.H. J. Biol. Chem. (1993) [Pubmed]
  5. Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound. Sich, B., Kirch, U., Tepel, M., Zidek, W., Schoner, W. Hypertension (1996) [Pubmed]
  6. Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps. Scheiner-Bobis, G. Naunyn Schmiedebergs Arch. Pharmacol. (2001) [Pubmed]
  7. On the pharmacokinetics of proscillaridin A in man. Andersson, K.E., Bertler, A., Redfors, A. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  8. Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure. Schneider, R., Antolovic, R., Kost, H., Sich, B., Kirch, U., Tepel, M., Zidek, W., Schoner, W. Clin. Exp. Hypertens. (1998) [Pubmed]
  9. Simeon Solomon and the biblical construction of marginal identity in Victorian England. Seymour, G.M. Journal of homosexuality. (1997) [Pubmed]
  10. Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities. Li, S., Eim, C., Kirch, U., Lang, R.E., Schoner, W. Life Sci. (1998) [Pubmed]
  11. Biliary excretion and enterochepatic recycling of proscillaridin A after oral adminstration to man. Andersson, K.E., Bergdahl, B., Wettrell, G. Eur. J. Clin. Pharmacol. (1977) [Pubmed]
  12. Proscillaridin activity in portal and peripheral venous blood after oral administration to man. Andersson, K.E., Bergdahl, B., Dencker, H., Wettrell, G. Eur. J. Clin. Pharmacol. (1977) [Pubmed]
  13. Activities of proscillaridin A in thoracic duct lymph after single oral doses in man. Andersson, K.E., Bergdahl, B., Dencker, H., Wettrell, G. Acta pharmacologica et toxicologica. (1977) [Pubmed]
  14. Role of endogenous cardiac glycosides in the spontaneously hypertensive rat--antagonism by active immunization. Nguyen, A.T., Doris, P.A. Am. J. Hypertens. (1996) [Pubmed]
  15. Cardiotonic drugs inhibit purified mammalian acetylcholinesterase. Hanke, D.W., Nelson, M.E., Baskin, S.I. Journal of applied toxicology : JAT. (1991) [Pubmed]
  16. Pharmacokinetics and pharmacodynamics of methyl proscillaridin in healthy man. Belz, G.G., Schreiter, H., Wolf, G.K. Eur. J. Clin. Pharmacol. (1976) [Pubmed]
  17. Excretion of methylproscillaridin in patients with a biliary fistula. Staud, R., Rietbrock, N., Fassbender, H.P. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  18. Determination of proscillaridin in plasma by radioimmunoassay. Kojima, K., Yamamoto, K., Terauchi, Y., Kagemoto, A., Naruto, S., Nakanishi, Y. J. Pharmacobio-dyn. (1986) [Pubmed]
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