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Chemical Compound Review

Obidoxim     oxo-[[1-[[4- (oxoazaniumylmethylidene) pyrid...

Synonyms: Obidoxime, Toxobidin, Toxogonin, Toksobidin, Toxogonine, ...
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Disease relevance of 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine


High impact information on 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine

  • The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE [4].
  • The potassium (51 mM) evoked release of [(3)H]-acetylcholine and the liberation of [(3)H]-choline were determined in hippocampal slices following in vitro exposure to soman and five oximes (toxogonin, HI-6, HLö-7, P2S and 2-PAM) in separate experiments by superfusion [5].
  • Only limited reactivation of the acetylcholinesterase activity was observed in superfusion experiments with toxogonin, HI-6, P2S and 2-PAM following exposure of hippocampal slices to soman [5].
  • In vitro effects of toxogonin, HI-6 and HLö-7 on the release of [3H]acetylcholine from peripheral cholinergic nerves in rat airway smooth muscle [6].
  • HI-6, but neither toxogonin nor PAM Cl, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase [1].

Chemical compound and disease context of 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine


Biological context of 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine


Anatomical context of 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine


Associations of 4-(nitrosomethylidene)-1-[[4-(nitrosomethylidene)pyridin-1-yl]methoxymethyl]pyridine with other chemical compounds


  1. Central activity of acetylcholinesterase oxime reactivators. Clement, J.G. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  2. Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators. Xue, S.Z., Ding, X.J., Ding, Y. Scandinavian journal of work, environment & health. (1985) [Pubmed]
  3. Effect of pyridostigmine pretreatment, HI-6 and Toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure. Walday, P., Aas, P., Haider, T., Fonnum, F. Arch. Toxicol. (1993) [Pubmed]
  4. Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro. Bedford, C.D., Miura, M., Bottaro, J.C., Howd, R.A., Nolen, H.W. J. Med. Chem. (1986) [Pubmed]
  5. Pre-junctional effects of oximes on [3H]-acetylcholine release in rat hippocampal slices during soman intoxication. Øydvin, O.K., Tansø, R., Aas, P. Eur. J. Pharmacol. (2005) [Pubmed]
  6. In vitro effects of toxogonin, HI-6 and HLö-7 on the release of [3H]acetylcholine from peripheral cholinergic nerves in rat airway smooth muscle. Aas, P. Eur. J. Pharmacol. (1996) [Pubmed]
  7. Effect of toxogonin and P2S on the toxicity of carbamates and organophosphorus compounds. Sterri, S.H., Rognerud, B., Fiskum, S.E., Lyngaas, S. Acta pharmacologica et toxicologica. (1979) [Pubmed]
  8. HI-6 therapy of soman and tabun poisoning in primates and rodents. Hamilton, M.G., Lundy, P.M. Arch. Toxicol. (1989) [Pubmed]
  9. Side effects of phosphorylated acetylcholinesterase reactivators on neuronal membrane and synaptic transmission. Fossier, P., Tauc, L., Baux, G. Pflugers Arch. (1983) [Pubmed]
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