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Chemical Compound Review

Azidoalanine     2-amino-3-azido-propanoic acid

Synonyms: D-Azidoalanine, L-Azidoalanine, CCRIS 1789, CCRIS 1790, CCRIS 1792, ...
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Disease relevance of CCRIS 1789


High impact information on CCRIS 1789


Biological context of CCRIS 1789


Associations of CCRIS 1789 with other chemical compounds

  • The in vitro synthesized sodium azide mutagenic metabolite (azidoalanine) produced single-strand breaks and proteinase K-sensitive sites in isolated, germinating barley embryos [8].

Analytical, diagnostic and therapeutic context of CCRIS 1789

  • The levels of mutagenic metabolite of azide (presumably azidoalanine), were determined by bioassay in the two azide-treated maize callus types and compared to levels of mutagenic metabolite in embryos isolated from azide-treated kernels [9].


  1. Azidoalanine mutagenicity in Salmonella: effect of homologation and alpha-methyl substitution. Mangold, J.B., Mischke, M.R., LaVelle, J.M. Mutat. Res. (1989) [Pubmed]
  2. The lack of L-azidoalanine interaction with DNA. In vitro studies. Owais, W.M. Mutat. Res. (1993) [Pubmed]
  3. Synthesis and enantioselective mutagenicity of azidoalanine in Salmonella typhimurium. Mangold, J.B., Lavelle, J.M. Chem. Biol. Interact. (1986) [Pubmed]
  4. Mutagenicity of sodium azide and its metabolite azidoalanine in Drosophila melanogaster. Sadiq, M.F., Owais, W.M. Mutat. Res. (2000) [Pubmed]
  5. Genotoxicity of azidoalanine in mammalian cells. Arenaz, P., Hallberg, L. Environ. Mol. Mutagen. (1989) [Pubmed]
  6. Sodium azide mutagenesis in mammals: inability of mammalian cells to convert azide to a mutagenic intermediate. Arenaz, P., Hallberg, L., Mancillas, F., Gutierrez, G., Garcia, S. Mutat. Res. (1989) [Pubmed]
  7. Structure-activity relationships of the azide metabolite, azidoalanine, in S. typhimurium. LaVelle, J.M., Mangold, J.B. Mutat. Res. (1987) [Pubmed]
  8. Interaction of the mutagenic metabolite of sodium azide, synthesized in vitro, with DNA of barley embryos. Velemínský, J., Rosichan, J.L., Jurícek, M., Kleinhofs, A., Nilan, R.A., Gichner, T. Mutat. Res. (1987) [Pubmed]
  9. Differential metabolism of sodium azide in maize callus and germinating embryos. Dotson, S.B., Somers, D.A. Mutat. Res. (1989) [Pubmed]
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