Disease relevance of sulfamic acid

• Aminosulfonic acid buffer preserves myocardium during prolonged ischemia [1].
• Sulfamate is an analogue of thiosulfate, and the sodium and potassium salts of sulfamic acid inhibited the chemolithoautotrophic growth on thiosulfate of Acidithiobacillus ferrooxidans and Halothiobacillus neapolitanus [2].

High impact information on sulfamic acid

• The X-ray crystal structure of the best-studied isozyme, CA II, with three sulfamates (sulfamic acid, topiramate, and EMATE) has recently been reported, which allowed for a rationale drug design of new inhibitors [3].
• X-ray crystal structures of the adducts of human carbonic anhydrase (hCA) isozyme II with derivatives incorporating a sulfamide or sulfamic acid moiety are reported [4].
• Sulfamic acid 2-[4-(1H-imidazol-1-yl)phenoxy]ethyl ester monohydrochloride (16) has the best combination of properties and showed excellent topical activity in lowering the intraocular pressure in New Zealand white rabbits [5].
• Hepsulfam (sulfamic acid 1,7-heptanediyl ester, NSC 329680) is an alkylating agent currently in Phase I clinical trials [6].
• Sulfamic acid diester was taken up by blood cells and only slowly eliminated with a whole blood gamma half-life of 42 h in the dog and 32 h in the mouse [7].

Biological context of sulfamic acid

• The pharmacokinetics and metabolism of sulfamic acid diester were studied in the beagle dog and mouse [7].
• Protein binding of sulfamic acid diester in human plasma is 82% at 10 micrograms/ml and 68% at 100 micrograms/ml [8].
• ANCP purification was followed by nitrosation, sulfamic acid treatment, and analysis for ANC [9].
• CONCLUSIONS: MOCA measured in sulfamic acid-protected urine samples without hydrolysis provides a more practical and reliable biomarker than "total" MOCA (after hydrolysis) or "free" MOCA [10].

Anatomical context of sulfamic acid

• At 50 and 100 micrograms/ml sulfamic acid diester, the half-time in whole blood is 6.9 h and 65% of the drug is sequestered by the blood cells [8].
• Using an improved method for determination of total N-nitroso compounds (NOC), we examined the stability of those compounds in fresh gastric juice samples during storage and the effects of the addition of 2% sulphamic acid on NOC concentration in 212 samples [11].

Associations of sulfamic acid with other chemical compounds

• From TLC, HPLC, and mass spectral studies, 1 initially degraded to sulfamic acid 1,7-heptanemonoyl ester and subsequently to 1,7-heptanediol [12].
• The experimental parameters were examined by varying various reaction conditions such as pH, zinc feeding time, amount of sulfamic acid, and amount of nitrate concentration [13].
• NOC were determined after sulfamic acid treatment to destroy nitrite, and NOCP were determined after treatment with 110 mM nitrite and then sulfamic acid [14].
• Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design [15].
• Sulfamic acid cleaning solution for 4,4'-methylene-bisorthochloroaniline (MOCA) [16].

Analytical, diagnostic and therapeutic context of sulfamic acid

• Sulfamic acid as a standard substance in non-aqueous titrimetry [17].
• Induction and suppression of aminosulfonic acid spikes in Wulst EEG of adult chickens [18].
• Amidosulfuric acid, a strong acid used as a reference material for volumetric analysis in Japan, was dried in a vacuum desiccator or heated at different temperatures, and then measured by Karl-Fischer titration, thermogravimetry/mass spectroscopy (TG-MS), ion chromatography and coulometric titration [19].

References