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Chemical Compound Review:

Rubidium-81 rubidium

Synonyms: AC1O3TJR, 18268-34-3, Rubidium, isotope of mass 81

Botvinick, E.H. et al., Lurie, A.J. et al., Berman, D.S. et al., Shea, M.J. et al., Lustyik, G. et al., et al.

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Disease relevance of rubidium

Noninvasive detection of regional myocardial ischemia using rubidium-81 and the scintillation camera: comparison with stress electrocardiography in patients with arteriographically documented coronary stenosis [1].
Single-photon emission tomography studies of rubidium-81 in the detection of ischaemic heart disease, using a stress-reinjection protocol [2].
Fifty-six patients who subsequently underwent selective coronary angiography were studied noninvasively with relative myocardial perfusion scintigraphy with rubidium-81 and graded stress electrocardiography in an attempt to evaluate the ability of these tests to identify the presence of significant ischemia and, indirectly, coronary stenosis [3].

High impact information on rubidium

Separately, rubidium-81 (81Rb); T1/2 = 4.58 hr) was given as a peripheral intravenous injection 2 hr before the study to allow this long-lived tracer to distribute in the potassium space of the myocardium [4].
The measurement of spleen perfusion in man: a non-invasive method using the ratio between Rubidium-81 and its decay product Krypton-81m [5].
The effect of idebenone on the passive K+ and Rb+ permeability of the brain cell membranes of CFY rats as revealed by the Rb+-discrimination ratio [6].

Analytical, diagnostic and therapeutic context of rubidium

Determination of improved myocardial perfusion after aortocoronary bypass surgery by exercise rubidium-81 scintigraphy [7].
Revascularization was assessed in 15 patients by pre- and post-CBS rest and exercise rubidium-81 myocardial images with a scintillation camera equipped with pinhole collimator and high-energy shield [7].
Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography [8].
Myocardial stress perfusion scintigraphy with rubidium-81 versus stress electrocardiography [3].

References

Noninvasive detection of regional myocardial ischemia using rubidium-81 and the scintillation camera: comparison with stress electrocardiography in patients with arteriographically documented coronary stenosis. Berman, D.S., Salel, A.F., DeNardo, G.L., Mason, D.T. Circulation (1975) [Pubmed]
Single-photon emission tomography studies of rubidium-81 in the detection of ischaemic heart disease, using a stress-reinjection protocol. Botsch, H., Beringer, K., Petersen, J., Bauer, B., Weidemann, H. European journal of nuclear medicine. (1994) [Pubmed]
Myocardial stress perfusion scintigraphy with rubidium-81 versus stress electrocardiography. Botvinick, E.H., Shames, D.M., Gershengorn, K.M., Carlsson, E., Ratshin, R.A., Parmley, W.W. Am. J. Cardiol. (1977) [Pubmed]
Use of short- and long-lived rubidium tracers for the study of transient ischemia. Shea, M.J., Wilson, R.A., deLandsheere, C.M., Deanfield, J.E., Watson, I.A., Kensett, M.J., Jones, T., Selwyn, A.P. J. Nucl. Med. (1987) [Pubmed]
The measurement of spleen perfusion in man: a non-invasive method using the ratio between Rubidium-81 and its decay product Krypton-81m. Jones, T., Pettit, J.E., Rhodes, C.G., Waters, S.L. European journal of nuclear medicine. (1977) [Pubmed]
The effect of idebenone on the passive K+ and Rb+ permeability of the brain cell membranes of CFY rats as revealed by the Rb+-discrimination ratio. Lustyik, G., Szállási, Z., Jeney, F., Zs -Nagy, I. Archives of gerontology and geriatrics. (1990) [Pubmed]
Determination of improved myocardial perfusion after aortocoronary bypass surgery by exercise rubidium-81 scintigraphy. Lurie, A.J., Salel, A.F., Berman, D.S., DeNardo, G.L., Hurley, E.J., Mason, D.T. Circulation (1976) [Pubmed]
Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography. Cherry, S.R., Carnochan, P., Babich, J.W., Serafini, F., Rowell, N.P., Watson, I.A. J. Nucl. Med. (1990) [Pubmed]

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