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MeSH Review

Coronary Stenosis

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Disease relevance of Coronary Stenosis


High impact information on Coronary Stenosis

  • Regardless of age the relative risk of akinesis or dyskinesis, adjusted for coronary stenosis, was significant: 1.84 (1.28 to 2.65) for men under 55 and 1.57 (1.12 to 2.19) for men 55 or older [6].
  • Angiographic studies have shown beneficial effects of pravastatin on coronary stenosis when initiated after a coronary event [7].
  • Therefore, phosphorus-31 nuclear magnetic resonance spectroscopy was employed in an in vivo porcine model of graded coronary stenosis [8].
  • Thus, (a) treadmill exercise promotes the development of cyclic flow variations in dogs with coronary stenoses and endothelial injury; (b) ventricular pacing does not induce cyclic flow variations in most dogs in the same model; and (c) TXA2 and/or serotonin are important mediators of cyclic flow variations in this model [9].
  • Using this canine model, we tested the hypotheses: (a) that thrombin is an important mediator of CFVs in dogs with coronary stenoses and endothelial injury; (b) that inhibition of thrombin with heparin, or MCI-9038, a selective thrombin inhibitor, abolishes CFVs in this model; and (c) that abolition of CFVs by thrombin inhibition is time dependent [10].

Chemical compound and disease context of Coronary Stenosis


Biological context of Coronary Stenosis


Anatomical context of Coronary Stenosis

  • METHODS AND RESULTS: The selective bradykinin B2 receptor antagonist HOE 140 was infused into the left main coronary artery (200 micrograms/min for 15 minutes) in 15 patients without significant coronary stenoses [21].
  • CONCLUSIONS: When myocardial necrosis coexists with post-ischemic myocardial dysfunction and no residual coronary stenosis, the absolute degree of wall thickening during dobutamine can be used to determine the extent of myocardium that has escaped necrosis [22].
  • Finally, activation of the catalytic unit of adenylyl cyclase by forskolin and GTP was not altered by coronary stenosis, however, basal cyclic AMP in myocytes was depressed at 14 days [23].
  • BACKGROUND: Although isoflurane may cause subendocardial hypoperfusion in the presence of coronary stenosis because of its coronary arteriolar dilatory effects, it is not known how the subendocardial microcirculation is affected [24].
  • CONCLUSIONS: Acute inflammatory markers such as high neutrophil count, CRP concentration, and neopterin concentration correlate with the presence of multiple angiographically complex coronary stenoses [25].

Gene context of Coronary Stenosis

  • No difference in the score of coronary stenosis index (CSI) was found in FH with/without CETP deficiency, although CSI was inversely correlated with HDL-C levels (P < 0.05) [26].
  • Thus, the level of PAI activity under basal conditions reflected the extent of disease activity, suggesting that PAI activity may be a useful clinical indicator of the severity of rest angina in patients without significant coronary stenosis [27].
  • LPL associated with sex (females>males) and LCAT with alcohol intake (drinkers>non-drinkers) although neither enzyme demonstrated direct correlation with coronary stenosis [28].
  • Complexity of coronary stenosis was positively correlated with tissue-type plasminogen activator (TPA) mass concentration (P < 0.01) and PAI activity (P < 0.05) [29].
  • We have recently reported a marked increase of basic FGF in the pericardial fluid of patients with severe coronary stenosis and an increase in vascular endothelial growth factor (VEGF) in the pericardial fluid of patients with severe myocardial ischemia [30].

Analytical, diagnostic and therapeutic context of Coronary Stenosis


  1. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia. McNulty, P.H., Sinusas, A.J., Shi, C.Q., Dione, D., Young, L.H., Cline, G.C., Shulman, G.I. J. Clin. Invest. (1996) [Pubmed]
  2. Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Haverkate, F., Thompson, S.G., Pyke, S.D., Gallimore, J.R., Pepys, M.B. Lancet (1997) [Pubmed]
  3. Prostacyclin: haemodynamic and metabolic effects in patients with coronary artery disease. Bergman, G., Daly, K., Atkinson, L., Rothman, M., Richardson, P.J., Jackson, G., Jewitt, D.E. Lancet (1981) [Pubmed]
  4. Coronary vasomotor effects of serotonin in patients with angina. Relation to coronary stenosis morphology. Tousoulis, D., Davies, G., McFadden, E., Clarke, J., Kaski, J.C., Maseri, A. Circulation (1993) [Pubmed]
  5. Direct comparison of [13N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Bol, A., Melin, J.A., Vanoverschelde, J.L., Baudhuin, T., Vogelaers, D., De Pauw, M., Michel, C., Luxen, A., Labar, D., Cogneau, M. Circulation (1993) [Pubmed]
  6. The association of smoking with cardiomyopathy. Hartz, A.J., Anderson, A.J., Brooks, H.L., Manley, J.C., Parent, G.T., Barboriak, J.J. N. Engl. J. Med. (1984) [Pubmed]
  7. Clinical relevance of statins: instituting treatment early in acute coronary syndrome patients. Thompson, P.L. Atherosclerosis. Supplements. (2001) [Pubmed]
  8. Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia. Phosphorus-31 nuclear magnetic resonance studies of porcine myocardium in vivo. Schaefer, S., Schwartz, G.G., Gober, J.R., Wong, A.K., Camacho, S.A., Massie, B., Weiner, M.W. J. Clin. Invest. (1990) [Pubmed]
  9. Treadmill exercise promotes cyclic alterations in coronary blood flow in dogs with coronary artery stenoses and endothelial injury. Eidt, J.F., Ashton, J., Golino, P., McNatt, J., Buja, L.M., Willerson, J.T. J. Clin. Invest. (1989) [Pubmed]
  10. Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury. Eidt, J.F., Allison, P., Noble, S., Ashton, J., Golino, P., McNatt, J., Buja, L.M., Willerson, J.T. J. Clin. Invest. (1989) [Pubmed]
  11. Coronary stenosis dilatation induced by L-arginine. Tousoulis, D., Davies, G., Tentolouris, C., Crake, T., Toutouzas, P. Lancet (1997) [Pubmed]
  12. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Chen, C., Li, L., Chen, L.L., Prada, J.V., Chen, M.H., Fallon, J.T., Weyman, A.E., Waters, D., Gillam, L. Circulation (1995) [Pubmed]
  13. Serial thallium-201 myocardial imaging after dipyridamole infusion: diagnostic utility in detecting coronary stenoses and relationship to regional wall motion. Leppo, J., Boucher, C.A., Okada, R.D., Newell, J.B., Strauss, H.W., Pohost, G.M. Circulation (1982) [Pubmed]
  14. Quantitative thallium-201 redistribution with a fixed coronary stenosis in dogs. Leppo, J., Rosenkrantz, J., Rosenthal, R., Bontemps, R., Yipintsoi, T. Circulation (1981) [Pubmed]
  15. Comparison between 201Tl and 99mTc sestamibi uptake during adenosine-induced vasodilation as a function of coronary stenosis severity. Glover, D.K., Ruiz, M., Edwards, N.C., Cunningham, M., Simanis, J.P., Smith, W.H., Watson, D.D., Beller, G.A. Circulation (1995) [Pubmed]
  16. Adrenergic coronary vasoconstriction during myocardial underperfusion. Feigl, E.O., Buffington, C.W., Nathan, H.J. Circulation (1987) [Pubmed]
  17. Platelet membrane activation markers are predictive for increased risk of acute ischemic events after PTCA. Tschoepe, D., Schultheiss, H.P., Kolarov, P., Schwippert, B., Dannehl, K., Nieuwenhuis, H.K., Kehrel, B., Strauer, B., Gries, F.A. Circulation (1993) [Pubmed]
  18. Is esmolol cardioprotective? Tolerance of pacing tachycardia, acute afterloading and hemodilution in dogs with coronary stenosis. Spahn, D.R., Frasco, P.E., White, W.D., Smith, L.R., McRae, R.L., Leone, B.J. J. Am. Coll. Cardiol. (1993) [Pubmed]
  19. Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart. Steendijk, P., Baan, J., Van der Velde, E.T., Baan, J. J. Am. Coll. Cardiol. (1998) [Pubmed]
  20. Relation between myocardial thallium-201 kinetics during exercise and quantitative coronary angiography in patients with one vessel coronary artery disease. Hadjimiltiades, S., Watson, R., Hakki, A.H., Heo, J., Iskandrian, A.S. J. Am. Coll. Cardiol. (1989) [Pubmed]
  21. Role of endogenous bradykinin in human coronary vasomotor control. Groves, P., Kurz, S., Just, H., Drexler, H. Circulation (1995) [Pubmed]
  22. Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion. An experimental evaluation. Sklenar, J., Ismail, S., Villanueva, F.S., Goodman, N.C., Glasheen, W.P., Kaul, S. Circulation (1994) [Pubmed]
  23. Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes. Meggs, L.G., Huang, H.E., Li, B., Li, P., Coupet, J., Hamby, C.V., Akanuma, M., Ishikawa, Y., Anversa, P. Cardiovasc. Res. (1997) [Pubmed]
  24. Comparative effects of hypotension due to isoflurane, nitroglycerin, and adenosine on subendocardial microcirculation: observation of the in situ beating swine heart under critical stenosis. Fujita, Y., Habazettl, H., Corso, C.O., Messmer, K., Yada, T. Anesthesiology (1997) [Pubmed]
  25. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes. Avanzas, P., Arroyo-Espliguero, R., Cosín-Sales, J., Aldama, G., Pizzi, C., Quiles, J., Kaski, J.C. Heart (2004) [Pubmed]
  26. Clinical characteristics of double heterozygotes with familial hypercholesterolemia and cholesteryl ester transfer protein deficiency. Haraki, T., Inazu, A., Yagi, K., Kajinami, K., Koizumi, J., Mabuchi, H. Atherosclerosis (1997) [Pubmed]
  27. Plasminogen activator inhibitor activity as a possible indicator of disease activity in rest angina with angiographically insignificant coronary artery stenosis. Sakata, K., Kurata, C., Kobayashi, A., Rydzewski, A., Yamazaki, N. Thromb. Res. (1991) [Pubmed]
  28. Plasma concentrations of LPL and LCAT are in putative association with females and alcohol use which are independent negative risk factors for coronary atherosclerosis among Japanese. Goto, A., Sasai, K., Suzuki, S., Fukutomi, T., Ito, S., Matsushita, T., Okamoto, M., Suzuki, T., Itoh, M., Okumura-Noji, K., Yokoyama, S. Clin. Chim. Acta (2003) [Pubmed]
  29. Correlation between coronary morphology and molecular markers of fibrinolysis in unstable angina pectoris. Hoffmeister, H.M., Jur, M., Helber, U., Fischer, M., Heller, W., Seipel, L. Atherosclerosis (1999) [Pubmed]
  30. Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid. Iwakura, A., Fujita, M., Ikemoto, M., Hasegawa, K., Nohara, R., Sasayama, S., Miyamoto, S., Yamazato, A., Tambara, K., Komeda, M. Heart and vessels. (2000) [Pubmed]
  31. Detection of coronary artery stenosis in children with Kawasaki disease. Usefulness of pharmacologic stress 201Tl myocardial tomography. Kondo, C., Hiroe, M., Nakanishi, T., Takao, A. Circulation (1989) [Pubmed]
  32. Effect of nitroglycerin and nifedipine on subendocardial perfusion in the presence of a flow-limiting coronary stenosis in the awake dog. Bache, R.J., Tockman, B.A. Circ. Res. (1982) [Pubmed]
  33. Quantitative coronary angiography in the estimation of the functional significance of coronary stenosis: correlations with dobutamine-atropine stress test. Baptista, J., Arnese, M., Roelandt, J.R., Fioretti, P., Keane, D., Escaned, J., Boersma, E., di Mario, C., Serruys, P.W. J. Am. Coll. Cardiol. (1994) [Pubmed]
  34. Estrogen replacement and coronary artery disease. Effect on survival in postmenopausal women. Sullivan, J.M., Vander Zwaag, R., Hughes, J.P., Maddock, V., Kroetz, F.W., Ramanathan, K.B., Mirvis, D.M. Arch. Intern. Med. (1990) [Pubmed]
  35. Relation of perfusion defects observed with myocardial contrast echocardiography to the severity of coronary stenosis: correlation with thallium-201 single-photon emission tomography. Cheirif, J., Desir, R.M., Bolli, R., Mahmarian, J.J., Zoghbi, W.A., Verani, M.S., Quiñones, M.A. J. Am. Coll. Cardiol. (1992) [Pubmed]
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