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Chemical Compound Review

HOCH2CH2     ethanol

Synonyms: AC1O5EAN, CH2CH2OH, 116850-EP2272972A1, 116850-EP2272973A1, 116850-EP2277865A1, ...
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Disease relevance of ethanol

  • This decrease in surfactant was associated with impairment of the opsonic activity from BAL fluid in the ETH versus DEX animals using a standard assay of bacterial (Staphylococcus aureus) killing with normal polymorphonuclear leukocytes and BAL fluid as an opsonin [1].
  • Among paired dams, those designated submissive on the basis of agonistic behavior and drinking either SUC, ETH, or PG, had fewer viable pups and more fetal resorptions and stillborn pups than WAT dams [2].
  • BE was active against Salmonella typhimurium and Morganella morganii, and EE against Plesiomonas shigelloides, Shigella flexnerii and Sh. sonneii [3].
  • Antibacterial activity of petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanol (EE) extracts of dried Elaeocarpus sphaericus fruit was investigated against 28 gram-positive and gram-negative bacteria using the disc diffusion and plate dilution methods [3].
  • Aqueous (AE), ethanol (EE) and dichloromethane (DE) extracts from the whole plant of Anthurium cerrocampanense Croat, endemic to Panama, were assayed for antiinflammatory activity by carrageenan-induced rat paw edema and croton oil-induced mouse ear edema tests [4].

High impact information on ethanol

  • 3-Substituted pyrazoles, HOCH2 (1), HOCH2CH2 (2), HOCH2CH2CH2 (3), ClCH2 (4), ClCH2CH2 (5), ClCH2CH2CH2 (6), and CH3CO (7), were synthesized and evaluated in vitro on horse liver alcohol dehydrogenase for their potential as inhibitors of ethanol metabolism [5].
  • PE significantly increased plasma antioxidant capacity by 9% in Group E + PE and 18% in Group W + PE compared with their respective controls [6].
  • Nuclear preservation was best for DIR and inferior for AIR, ETH, SAC and HBSS [7].
  • Generally ER measurement requires fresh frozen tissue and for ER-D5 assay ethanol (E) fixation of the specimen is recommended [8].
  • The relationship between alcohol dehydrogenase (ADH) activity and survival appeared to be negative on E [9].

Biological context of ethanol

  • All genotypes showed greater survival in the presence of 10% ethanol (E) than on the control agar medium (C), with wild type showing greatest and the double mutant ebony-yellow least response [9].
  • The i.p. LD50 values were established to be 770 mg/kg and 280 mg/kg for the aqueous (WE) and ethanol (EE) extracts, respectively [10].

Associations of ethanol with other chemical compounds

  • PEWW and ETH significantly increased plasma antioxidant capacity and vitamin A concentrations [11].
  • The Carter MIR ozone potential of combined Federal Test Procedure (FTP) tailpipe and evaporative emissions was reduced more than 90% with CNG relative to RFG, M85, and E85 fuels [12].

Analytical, diagnostic and therapeutic context of ethanol


  1. Surfactant deficiency with decreased opsonic activity in a guinea pig model of alcoholism. Baughman, R.P., Roselle, G.A. Alcohol. Clin. Exp. Res. (1987) [Pubmed]
  2. Maternal social stress disrupts reproduction of hamsters drinking high-calorie fluids. Wise, D.A., Eldred, N.L. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  3. Antimicrobial activity of Elaeocarpus sphaericus. Singh, R.K., Nath, G. Phytotherapy research : PTR. (1999) [Pubmed]
  4. Antiinflammatory activity of Anthurium cerrocampanense Croat in rats and mice. Segura, L., Vila, R., Gupta, M.P., Espósito-Avella, M., Adzet, T., Cañigueral, S. Journal of ethnopharmacology. (1998) [Pubmed]
  5. 3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase. Fries, R.W., Bohlken, D.P., Plapp, B.V. J. Med. Chem. (1979) [Pubmed]
  6. Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). Auger, C., Caporiccio, B., Landrault, N., Teissedre, P.L., Laurent, C., Cros, G., Besançon, P., Rouanet, J.M. J. Nutr. (2002) [Pubmed]
  7. Comparison of different preparation techniques for fine needle aspiration specimens. A semiquantitative and statistical analysis. Crystal, B.S., Wang, H.H., Ducatman, B.S. Acta Cytol. (1993) [Pubmed]
  8. Value of ER-D5 immunocytochemical determination in routine tissue sections of human breast cancer. Giani, C., Campani, D., De Negri, F., Perpoli, F., Capotorti, E., Squartini, F., Pinchera, A. Int. J. Biol. Markers (1989) [Pubmed]
  9. Effect of ebony and yellow mutants of Drosophila melanogaster on adult survival and alcohol dehydrogenase activity. Soliman, M.H. Gerontology. (1987) [Pubmed]
  10. Studies on the antidiarrhoeal properties of pentaclethra macrophylla leaf extracts. Akah, P.A., Aguwa, C.N., Agu, R.U. Phytotherapy research : PTR. (1999) [Pubmed]
  11. Polyphenols-enriched Chardonnay white wine and sparkling Pinot Noir red wine identically prevent early atherosclerosis in hamsters. Auger, C., Rouanet, J.M., Vanderlinde, R., Bornet, A., Décordé, K., Lequeux, N., Cristol, J.P., Teissedre, P.L. J. Agric. Food Chem. (2005) [Pubmed]
  12. Alternative fuel motor vehicle tailpipe and evaporative emissions composition and ozone potential. Black, F., Tejada, S., Gurevich, M. Journal of the Air & Waste Management Association (1995) (1998) [Pubmed]
  13. Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn. Perianayagam, J.B., Sharma, S.K., Joseph, A., Christina, A.J. Journal of ethnopharmacology. (2004) [Pubmed]
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