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MeSH Review

Hyperthermia, Induced

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Disease relevance of Hyperthermia, Induced


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Chemical compound and disease context of Hyperthermia, Induced

  • METHODS: In a randomized, double-blind, placebo-controlled, crossover study, 10 subjects with rhinitis were treated for 30 minutes with local hyperthermia or placebo, which was followed 30 minutes later by nasal allergen challenge [12].
  • PURPOSE: This is the first study to evaluate the tolerability and activity of liposomal doxorubicin (Caelyx; Schering-Plough Pharmaceuticals) < or =60 mg/km(2) in patients with locally recurrent breast cancer, when administered in conjunction with reirradiation and local hyperthermia treatment [5].
  • BACKGROUND: Prior treatment with local hyperthermia has been shown to prevent mast cell degranulation and leucocyte histamine release, and to reduce mortality and cellular infiltrates in a model of acute lung injury [13].
  • Tumor growth delay (TGD) demonstrated that when the drugs were tested with radiation (3 Gy daily X 5) plus (43 degrees X 30 min) local hyperthermia, cisplatin/hyperthermia/radiation (TGD approximately 25 days) was significantly more effective than etoposide/hyperthermia/radiation (TGD approximately 14 days) [14].
  • In vivo, treatment of the FSaIIC tumor with misonidazole (1 g/kg) and/or local hyperthermia (43 degrees C for 30 min to the tumor-bearing limb) in conjunction with radiation (10, 20, or 30 Gy) yielded a radiation dose modifying factor for misonidazole of 1.32, for hyperthermia of 1.38, and for the combination of 2.06 (probably additive) [15].

Biological context of Hyperthermia, Induced


Anatomical context of Hyperthermia, Induced


Associations of Hyperthermia, Induced with chemical compounds


Gene context of Hyperthermia, Induced


Analytical, diagnostic and therapeutic context of Hyperthermia, Induced


  1. Local hyperthermia and SR 4233 enhance the antitumor effects of radioimmunotherapy in nude mice with human colonic adenocarcinoma xenografts. Wilder, R.B., Langmuir, V.K., Mendonca, H.L., Goris, M.L., Knox, S.J. Cancer Res. (1993) [Pubmed]
  2. Effects of interleukin 2 treatment combined with local hyperthermia in mice inoculated with Lewis lung carcinoma cells. Shen, R.N., Lu, L., Wu, B., Shidnia, H., Hornback, N.B., Broxmeyer, H.E. Cancer Res. (1990) [Pubmed]
  3. Selective delivery of liposome-associated cis-dichlorodiammineplatinum(II) by heat and its influence on tumor drug uptake and growth. Yatvin, M.B., Mühlensiepen, H., Porschen, W., Weinstein, J.N., Feinendegen, L.E. Cancer Res. (1981) [Pubmed]
  4. Enhanced therapeutic effect against liver W256 carcinosarcoma with temperature-sensitive liposomal adriamycin administered into the hepatic artery. Zou, Y., Yamagishi, M., Horikoshi, I., Ueno, M., Gu, X., Perez-Soler, R. Cancer Res. (1993) [Pubmed]
  5. Liposomal doxorubicin in conjunction with reirradiation and local hyperthermia treatment in recurrent breast cancer: a phase I/II trial. Kouloulias, V.E., Dardoufas, C.E., Kouvaris, J.R., Gennatas, C.S., Polyzos, A.K., Gogas, H.J., Sandilos, P.H., Uzunoglu, N.K., Malas, E.G., Vlahos, L.J. Clin. Cancer Res. (2002) [Pubmed]
  6. Therapeutic outcome and side-effects after radiotherapy, chemotherapy and/or hyperthermia treatment of head and neck tumour xenografts. Ressel, A., Schmitt, O., Weiss, C., Feyerabend, T. Eur. J. Cancer (2002) [Pubmed]
  7. Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Weinstein, J.N., Magin, R.L., Yatvin, M.B., Zaharko, D.S. Science (1979) [Pubmed]
  8. Treatment of perennial allergic rhinitis by local hyperthermia. Yerushalmi, A., Karman, S., Lwoff, A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  9. Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. Meyer, D.E., Kong, G.A., Dewhirst, M.W., Zalutsky, M.R., Chilkoti, A. Cancer Res. (2001) [Pubmed]
  10. Hyperthermia enhances tumor uptake and antitumor efficacy of thermostable liposomal daunorubicin in a rat solid tumor. van Bree, C., Krooshoop, J.J., Rietbroek, R.C., Kipp, J.B., Bakker, P.J. Cancer Res. (1996) [Pubmed]
  11. Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaIIC murine fibrosarcoma. Teicher, B.A., Holden, S.A., al-Achi, A., Herman, T.S. Cancer Res. (1990) [Pubmed]
  12. The effect of local hyperthermia on allergen-induced nasal congestion and mediator release. Johnston, S.L., Price, J.N., Lau, L.C., Walls, A.F., Walters, C., Feather, I.H., Holgate, S.T., Howarth, P.H. J. Allergy Clin. Immunol. (1993) [Pubmed]
  13. Attenuation of exercise induced asthma by local hyperthermia. Johnston, S.L., Perry, D., O'Toole, S., Summers, Q.A., Holgate, S.T. Thorax (1992) [Pubmed]
  14. The interaction of cisplatin plus etoposide with radiation +/- hyperthermia. Pfeffer, M.R., Teicher, B.A., Holden, S.A., al-Achi, A., Herman, T.S. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  15. Effect of environmental conditions (pH, oxygenation, and temperature) on misonidazole cytotoxicity and radiosensitization in vitro and in vivo in FSaIIC fibrosarcoma. Holden, S.A., Teicher, B.A., Herman, T.S. Int. J. Radiat. Oncol. Biol. Phys. (1991) [Pubmed]
  16. Phosphatidylinositol 3-kinase-dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced diabetic heart. Shinohara, T., Takahashi, N., Ooie, T., Hara, M., Shigematsu, S., Nakagawa, M., Yonemochi, H., Saikawa, T., Yoshimatsu, H. Diabetes (2006) [Pubmed]
  17. Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells. Okamoto, K., Shinoura, N., Egawa, N., Asai, A., Kirino, T., Shibasaki, F., Shitara, N. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  18. Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse. Honess, D.J., Workman, P., Morgan, J.E., Bleehen, N.M. Br. J. Cancer (1980) [Pubmed]
  19. Mechanisms of hyperthermia- and 4-hydroperoxy-ifosfamide-induced cytotoxicity in T cell leukemia. Mauz-Körholz, C., Dietzsch, S., Banning, U., Tröbs, R.B., Körholz, D. Anticancer Res. (2002) [Pubmed]
  20. Differential enhancement of cytotoxicity by combination of the carcinostatic agent benzaldehyde and hyperthermia in simian virus 40-transformed and normal cell lines. Ishida, A., Miwa, N., Mizuno, S. Cancer Res. (1983) [Pubmed]
  21. Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Kim, J.H., Kim, S.H., Alfieri, A.A., Young, C.W. Cancer Res. (1984) [Pubmed]
  22. The influence of hyperthermia on the uptake of cisplatin in the rat cervical spinal cord. Sminia, P., Los, G., Hendriks, J.J., van Vugt, M.J., Haveman, J., González González, D. Eur. J. Cancer (1992) [Pubmed]
  23. Involvement of central histaminergic neurons in polypnea induced by hyperthermia in rabbits. Iwase, M., Izumizaki, M., Kanamaru, M., Homma, I. Neurosci. Lett. (2001) [Pubmed]
  24. Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells. Li, F.J., Kondo, T., Zhao, Q.L., Tanabe, K., Ogawa, R., Li, M., Arai, Y. Free Radic. Res. (2001) [Pubmed]
  25. Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia. Magin, R.L., Sikic, B.I., Cysyk, R.L. Cancer Res. (1979) [Pubmed]
  26. Sequencing of trimodality therapy [cis-diamminedichloroplatinum(II)/hyperthermia/radiation] as determined by tumor growth delay and tumor cell survival in the FSaIIC fibrosarcoma. Herman, T.S., Teicher, B.A. Cancer Res. (1988) [Pubmed]
  27. Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models. Robins, H.I., Dennis, W.H., Slattery, J.S., Lange, T.A., Yatvin, M.B. Cancer Res. (1983) [Pubmed]
  28. Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells. Kapp, D.S., Hahn, G.M. Cancer Res. (1979) [Pubmed]
  29. Hyperthermia with simultaneous administration of interferon using established human renal carcinoma heterotransplanted in nude mice. Onishi, T., Machida, T., Mori, Y., Iizuka, N., Masuda, F., Mochizuki, S., Tsukamoto, H., Harada, N. British journal of urology. (1989) [Pubmed]
  30. The effect of in vivo hyperthermia on selected lymphokines in man. Downing, J.F., Taylor, M.W. Lymphokine Res. (1987) [Pubmed]
  31. The effects of dopamine D-1 and D-2 receptor agonists on body temperature in male mice. Sánchez, C. Eur. J. Pharmacol. (1989) [Pubmed]
  32. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. Zhang, H.J., Doctrow, S.R., Xu, L., Oberley, L.W., Beecher, B., Morrison, J., Oberley, T.D., Kregel, K.C. FASEB J. (2004) [Pubmed]
  33. Age-related maculopathy: pathogenetic features and new treatment modalities. Algvere, P.V., Seregard, S. Acta ophthalmologica Scandinavica. (2002) [Pubmed]
  34. Self-expandable coated stent after intraluminal treatment of esophageal cancer: a risky procedure? Maier, A., Pinter, H., Friehs, G.B., Renner, H., Smolle-Jüttner, F.M. Ann. Thorac. Surg. (1999) [Pubmed]
  35. Localized thermo-cisplatin therapy: a pilot study in spontaneous canine and feline tumours. Théon, A.P., Madewell, B.R., Moore, A.S., Stephens, C., Krag, D.N. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (1991) [Pubmed]
  36. Effects of p53 gene therapy in radiotherapy or thermotherapy of human head and neck squamous cell carcinoma cell lines. Higuchi, Y., Asaumi, J., Murakami, J., Matsuzaki, H., Wakasa, T., Inoue, T., Shigehara, H., Konouchi, H., Hisatomi, M., Kawasaki, S., Hiraki, Y., Kishi, K. Oncol. Rep. (2003) [Pubmed]
  37. Temperature dependence of canine brain tissue diffusion coefficient measured in vivo with magnetic resonance echo-planar imaging. MacFall, J., Prescott, D.M., Fullar, E., Samulski, T.V. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (1995) [Pubmed]
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