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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fetal Resorption

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Disease relevance of Fetal Resorption


Psychiatry related information on Fetal Resorption


High impact information on Fetal Resorption

  • Fetal resorptions reflecting in utero death were genotyped using the polymerase chain reaction and found to be increased 2.6-fold and 3.6-fold respectively with heterozygous and homozygous p53-deficient embryos [7].
  • Given our preliminary findings of low IL-3 in mice with APLS and the efficacy of IL-3 in preventing fetal loss in a strain of mice prone to fetal resorption, our aim in the present study was to examine the effect of murine recombinant IL-3 (mrIL-3) on pregnant mice induced with experimental APLS [8].
  • Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid [9].
  • Here we show that litters from untreated pregnant mutant mice with a hereditary G6PD deficiency had increased prenatal (fetal resorptions) and postnatal death [10].
  • Blastocysts cultured in the presence of LY-294002 demonstrate a dramatic increase in fetal resorptions as compared with control embryos [11].

Chemical compound and disease context of Fetal Resorption


Biological context of Fetal Resorption

  • The latter could significantly be prevented by simultaneous administration of exogenous progesterone, indicating luteolysis as the major, if not sole, factor responsible for fetal resorption in the untreated horn [17].
  • Regardless of the duration of dietary copper deprivation, feeding the fructose diet deficient in copper during pregnancy resulted in either fetal resorption or mortality of all newborn pups during the first few hours postpartum [18].
  • Certain preparations of rabbit gamma-globulins (Cohn Fraction II) contain an activity which, if administered intravenously to pregnant mice, causes either complete fetal resorption in virtually 100% of cases when given during the second trimester equivalent or abortions when given later in pregnancy [19].
  • From a developmental standpoint, fetal growth and viability were reduced in correlation with treatment-related effects of diepoxybutane on implantation losses and fetal resorptions on gestation day 9 [20].
  • The effect of various doses of anordrin and RU 486, alone or combined, on serum progesterone (P) levels, fetal resorption, and recovery of ovulation was studied in mice [21].

Anatomical context of Fetal Resorption


Gene context of Fetal Resorption


Analytical, diagnostic and therapeutic context of Fetal Resorption

  • RESULTS: Whereas the administration of 1 microgram of LPS to CFW female x CFW male pregnant mice on day 7 of gestation induced complete fetal resorption, prior immunization with 20 micrograms of LPS completely prevented LPS induced abortion as long as the anti-LPS antibody titers remained above a threshold value of about 1/500 [28].


  1. Dimethoxyethyl phthalate: embryopathy, teratogenicity, fetal metabolism and the role of zinc in the rat. Parkhie, M.R., Webb, M., Norcross, M.A. Environ. Health Perspect. (1982) [Pubmed]
  2. Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice. Wells, P.G., Vo, H.P. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  3. Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase. Wells, P.G., Zubovits, J.T., Wong, S.T., Molinari, L.M., Ali, S. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  4. Prevention of fetal loss in experimental antiphospholipid syndrome by low-molecular-weight heparin. Inbar, O., Blank, M., Faden, D., Tincani, A., Lorber, M., Shoenfeld, Y. Am. J. Obstet. Gynecol. (1993) [Pubmed]
  5. Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation. Hayakawa, S., Fujikawa, T., Fukuoka, H., Chisima, F., Karasaki-Suzuki, M., Ohkoshi, E., Ohi, H., Kiyoshi Fujii, T., Tochigi, M., Satoh, K., Shimizu, T., Nishinarita, S., Nemoto, N., Sakurai, I. J. Reprod. Immunol. (2000) [Pubmed]
  6. Maternal social stress disrupts reproduction of hamsters drinking high-calorie fluids. Wise, D.A., Eldred, N.L. Pharmacol. Biochem. Behav. (1986) [Pubmed]
  7. A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nicol, C.J., Harrison, M.L., Laposa, R.R., Gimelshtein, I.L., Wells, P.G. Nat. Genet. (1995) [Pubmed]
  8. Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3. Fishman, P., Falach-Vaknine, E., Zigelman, R., Bakimer, R., Sredni, B., Djaldetti, M., Shoenfeld, Y. J. Clin. Invest. (1993) [Pubmed]
  9. Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid. White, J.C., Shankar, V.N., Highland, M., Epstein, M.L., DeLuca, H.F., Clagett-Dame, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis. Nicol, C.J., Zielenski, J., Tsui, L.C., Wells, P.G. FASEB J. (2000) [Pubmed]
  11. Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. Riley, J.K., Carayannopoulos, M.O., Wyman, A.H., Chi, M., Moley, K.H. J. Biol. Chem. (2006) [Pubmed]
  12. Termination of pregnancy by sheep anti-LHRH gamma globulin in rats. Nishi, N., Arimura, A., de la Cruz, K.G., Schally, A.V. Endocrinology (1976) [Pubmed]
  13. Synthesis and evaluation of the male antifertility properties of a series of N-unsubstituted sulfamates. Hirsch, A.F., Kasulanis, C., Kraft, L., Mallory, R.A., Powell, G., Wong, B. J. Med. Chem. (1981) [Pubmed]
  14. Maintenance of pregnancy in ovariectomized rats with steroid analogs and the reproductive ability of the progeny. Macdonald, G.J. Biol. Reprod. (1982) [Pubmed]
  15. Vitam A deficiency and fetal growth and development in the rat. Takahashi, Y.I., Smith, J.E., Winick, M., Goodman, D.S. J. Nutr. (1975) [Pubmed]
  16. Retinol in addition to retinoic acid is required for successful gestation in vitamin A-deficient rats. Wellik, D.M., DeLuca, H.F. Biol. Reprod. (1995) [Pubmed]
  17. Luteolytic influence of intrauterine dead embryos in the early pregnant rat. Kabir, S.N., Pal, A.K., Pakrashi, A. Biol. Reprod. (1984) [Pubmed]
  18. Copper-carbohydrate interaction in maternal, fetal and neonate rat. Fields, M., Lewis, C.G., Beal, T. Neurotoxicology and teratology. (1988) [Pubmed]
  19. An activity derived from rabbit serum causing interruption of pregnancy in mice. Waters, C.A., Singh, B., Honore, L. American journal of reproductive immunology and microbiology : AJRIM. (1985) [Pubmed]
  20. Uterine-ovarian biochemical and developmental interactions to the postimplantation treatment with a butadiene metabolite, diepoxybutane, in pregnant rats. Chi, L., Nixon, E., Spencer, F. J. Biochem. Mol. Toxicol. (2002) [Pubmed]
  21. Additive effect of RU 486 and anordrin on pregnancy interruption in the mouse. Forcelledo, M.L., Cardenas, H., Croxatto, H.B. Contraception. (1993) [Pubmed]
  22. Regression of corpora lutea in the rabbit after injection of a gonadotropin-releasing peptide. Rippel, R.H., Johnson, E.S., Kimura, E.T. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  23. Maintenance of decidual cell reaction by androgens in the mouse. Zhang, X., Croy, B.A. Biol. Reprod. (1996) [Pubmed]
  24. Lipopolysaccharide-induced fetal resorption in mice is associated with the intrauterine production of tumour necrosis factor-alpha. Gendron, R.L., Nestel, F.P., Lapp, W.S., Baines, M.G. J. Reprod. Fertil. (1990) [Pubmed]
  25. Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption. Shimada, S., Iwabuchi, K., Watano, K., Shimizu, H., Yamada, H., Minakami, H., Onoé, K. Am. J. Reprod. Immunol. (2003) [Pubmed]
  26. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells. Krishnan, L., Guilbert, L.J., Wegmann, T.G., Belosevic, M., Mosmann, T.R. J. Immunol. (1996) [Pubmed]
  27. CSF-1 induces resorption of embryos in mice. Tartakovsky, B. Immunol. Lett. (1989) [Pubmed]
  28. Immunological prevention of spontaneous early embryo resorption is mediated by non-specific immunosimulation. Baines, M.G., Duclos, A.J., de Fougerolles, A.R., Gendron, R.L. Am. J. Reprod. Immunol. (1996) [Pubmed]
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