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Chemical Compound Review

PTX-B     (E,2R,3S,8Z)-8-[(8S,8aS)-8- hydroxy-8...

Synonyms: Pumiliotoxin B, AC1O5NIY, LS-98103, 67016-65-3
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Disease relevance of Pumiliotoxin B


High impact information on Pumiliotoxin B


Biological context of Pumiliotoxin B


Anatomical context of Pumiliotoxin B


Gene context of Pumiliotoxin B

  • In whole-cell patch-clamp recordings of isolated CA1 and CA3 neurons, 1-2 microM pumiliotoxin-B shifted the midpoint of Na+ current activation by -11.4 +/- 1.1 mV [7].


  1. Interaction of pumiliotoxin B with an "alkaloid-binding domain" on the voltage-dependent sodium channel. Gusovsky, F., Padgett, W.L., Creveling, C.R., Daly, J.W. Mol. Pharmacol. (1992) [Pubmed]
  2. Pumiliotoxin B binds to a site on the voltage-dependent sodium channel that is allosterically coupled to other binding sites. Gusovsky, F., Rossignol, D.P., McNeal, E.T., Daly, J.W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. The pharmacology of pumiliotoxin-B. I. Interaction with calcium sites in the sarcoplasmic reticulum of skeletal muscle. Albuquerque, E.X., Warnick, J.E., Maleque, M.A., Kauffman, F.C., Tamburini, R., Nimit, Y., Daly, J.W. Mol. Pharmacol. (1981) [Pubmed]
  4. Pumiliotoxin B-like alkaloid in extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea: effects on the systemic blood pressure of experimental animals and the rat heart. Erspamer, G.F., Severini, C., Erspamer, V., Melchiorri, P. Neuropharmacology (1989) [Pubmed]
  5. Pharmacology of the alkaloid pumiliotoxin-B. II. Possible involvement of calcium and sodium-dependent processes in nerve and skeletal muscle. Rao, K.S., Warnick, J.E., Daly, J.W., Albuquerque, E.X. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  6. The effect of pumiliotoxin-B on the excitability of bullfrog sympathetic neurons. Schofield, G.G., Weight, F.F., Ikeda, S.R. Eur. J. Pharmacol. (1988) [Pubmed]
  7. The effects of pumiliotoxin-B on sodium currents in guinea pig hippocampal neurons. Sheridan, R.E., Deshpande, S.S., Lebeda, F.J., Adler, M. Brain Res. (1991) [Pubmed]
  8. Neuropeptide Y release by pumiliotoxin-B in the electrically-stimulated mouse vas deferens: an immunohistochemical study. D'Este, L., Falconieri-Erspamer, G., Severini, C., Erspamer, V., Renda, T.G. Peptides (1999) [Pubmed]
  9. Phosphorimaging detection and quantitation for isotopic ion flux assays. Fitch, R.W., Daly, J.W. Anal. Biochem. (2005) [Pubmed]
  10. Electrophysiological effects of a neurotoxin extracted from the skin of the Australian frog Pseudophryne coriacea. Sacchi, O., Bardoni, R., Magherini, P.C., Belluzzi, O. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
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