Disease relevance of CA3

• After brief application of each drug (10 min), LTP in CA1 and CA3 was induced by tetanus stimulation delivered to commissural/associational fibers and mossy fibers, respectively [1].
• Expression of testosterone-dependent enzyme, carbonic anhydrase III, and oxidative stress in experimental alcoholic liver disease [2].

High impact information on CA3

• In two instances, simultaneous recordings were obtained from coupled pairs of elements that were presumed to be soma and dendrite of the same CA3 pyramidal neuron [3].
• Actions of endogenous opioids on NMDA receptor-independent long-term potentiation in area CA3 of the hippocampus [4].
• More surprisingly, although kappa receptor binding is found in the rat dentate gyrus molecular layer and in the CA3 pyramidal cell layer, dynorphin had no action on perforant path field responses, somatic potassium currents or evoked monosynaptic inhibitory postsynaptic currents in CA3 cells [5].
• In 9 cases, it was possible to directly evaluate the compound EPSP (elicited by stimulating a group of CA3 neuron's axons) and the unitary EPSP (elicited by stimulating a single CA3 neuron) in the same CA1 neuron [6].
• Activation of group I metabotropic glutamate receptors (mGluRs) alters the firing patterns of individual CA3 pyramidal cells in guinea pig hippocampal slices [7].

Biological context of CA3

• Orthodromic stimuli evoked large-amplitude excitatory postsynaptic potentials, followed by inhibitory postsynaptic potentials in dendrites of CA1 and CA3 neurons [3].
• Long-term potentiation (LTP) was evaluated for small monosynaptic CA3-mediated EPSPs in CA1 neurons in the guinea pig hippocampal slice [6].
• Field potentials evoked by single-shock PSD stimulation were recorded in anesthetized guinea pigs from ENT, DG, fields CA2, CA1, and CA3 [8].
• 2. Slow small (2-5 mV) and large (up to 30 mV) K-IPSPs were observed in CA3, granule and in some hilar neurons during 4-AP applications in the presence of blockers for fast synaptic transmission, picrotoxin (50 microM), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 5-10 microM) [9].
• Bath-applied PTX, at concentrations of 50-200 microM, had no apparent effect on the resting membrane potential or input resistance of the CA3 cells tested [10].

Anatomical context of CA3

• Dynorphin A(1-17) or U69593 inhibited mossy fiber synaptic responses in preparations in which the CA3 region was surgically isolated from the rest of the hippocampus [11].
• The relationship between presynaptic calcium transients ([Ca2+]t) and transmitter release evoked by a single stimulus was both investigated experimentally and modeled at a mammalian central synapse, the CA3 to CA1 pyramidal cell synapse in guinea pig hippocampal slices [12].
• The discharge of layer II neurons was followed by the sequential activation of the dentate gyrus (DG), field CA3, field CA1 [8].
• The population spike of CA3 and CA1 pyramidal neurons as well as the response evoked in the entorhinal cortex by the hippocampal output had slightly higher threshold than the granule cell population spike and, like the latter, abruptly reached maximum amplitude [13].
• GABA application to hippocampal CA3 or CA1 stratum lacunosum-moleculare excites an interneuron network [14].

Associations of CA3 with chemical compounds

• Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors [7].
• Focal application of GABA to regions other than CA3 was also tested [14].
• The distribution of 3H-CHA binding was consistent among the species with the strata radiatum and oriens of fields CA1 and CA3 exhibiting the highest levels of binding [15].
• 3. Repetitive giant IPSPs, which consisted of Cl-dependent and K-dependent components, were evoked by bath application of 4-aminopyridine (4-AP, 10-50 microM) in CA3 neurons and in granule cells [16].
• In the CA3, GR89,696 inhibited the NMDA receptor-mediated synaptic current [17].

Other interactions of CA3

• GR, but not MR, mRNA expression was elevated in the hippocampus and dentate gyrus, whereas NR1 mRNA expression was increased in the CA1 and CA3 fields of the foetal hippocampus [18].
• In the hippocampus, CA2, CA3, and hilar, neurons demonstrated both BDNF- and TrkB-IR during development and maturation, whereas CA1 neurons showed TrkB-IR throughout this period but only transient BDNF-IR in early gestation [19].
• Mu opioid receptor activation reduces inhibitory postsynaptic potentials in hippocampal CA3 pyramidal cells of rat and guinea pig [20].
• We examined the effects of [Arg8]-vasopressin (AVP) on long term potentiation (LTP) of the field excitatory postsynaptic potentials at CA1 and CA3 synapses in adult guinea pig hippocampal slices [21].

Analytical, diagnostic and therapeutic context of CA3

• In both models, single epileptiform events were evoked by electrical stimulation of the Schaffer collaterals in CA1 or of stratum pyramidale in area CA3 [22].
• SD-like fluctuations of DC potential were recorded by inserting microelectrodes into the CA1 and CA3 regions [23].
• To clarify the importance of glucose metabolism in maintaining neural activity, we investigated the effects of lowering the concentration of glucose in perfusion medium on synaptic activity (population spikes, PS) and on the level of high energy phosphates in the region of dentate gyrus (DG), CA3 and CA1 area of hippocampal slices of guinea pig [24].
• Using this animal model, we have found that LTP is produced in both CA1 regions, following conditioning stimulation to the left CA3 [25].
• 1. CA-III was measured by enzyme-immunoassay in the livers of male and female swine aged from the fetus to 5 years old [26].

References