Gene Review:
Npy - neuropeptide Y
Mus musculus
Synonyms:
0710005A05Rik, Pro-neuropeptide Y
Holmes,
Smaldone,
Van der Ploeg,
Hurley,
Estrada,
Leibel,
Scharf,
Nishikibe,
Matsushita,
Okamoto,
O'Donnell,
Yumi Imai,
Hiral R. Patel,
Evan J. Hawkins,
Nicolai M. Doliba,
Franz M. Matschinsky,
Rexford S. Ahima,
Phelps,
Egashira,
Schwartz,
Chua,
Murai,
Tanaka,
Smith,
Guan,
Polotsky,
Crawley,
Macneil,
Jitsuoka,
Almond,
Heilig,
Korner,
Murai,
Li,
Savontaus,
Kanatani,
Bergen,
Mitobe,
Ishii,
Fukami,
Taylor,
Iwaasa,
Wardlaw,
Fukuroda,
Gomori,
Mashiko,
Ohe,
Tankersley,
Ishihara,
Mobbs,
Sato,
Karlsson,
Hidaka,
Birch,
Mizuno,
Ihara,
- Role of the Y5 neuropeptide Y receptor in feeding and obesity. Marsh, D.J., Hollopeter, G., Kafer, K.E., Palmiter, R.D. Nat. Med. (1998)
- Neuropeptide y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Patel, H.R., Qi, Y., Hawkins, E.J., Hileman, S.M., Elmquist, J.K., Imai, Y., Ahima, R.S. Diabetes (2006)
- Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice. Sainsbury, A., Schwarzer, C., Couzens, M., Herzog, H. Diabetes (2002)
- Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss. Chen, H., Hansen, M.J., Jones, J.E., Vlahos, R., Bozinovski, S., Anderson, G.P., Morris, M.J. Am. J. Respir. Crit. Care Med. (2006)
- Attenuation of diabetic hyperphagia in neuropeptide Y--deficient mice. Sindelar, D.K., Mystkowski, P., Marsh, D.J., Palmiter, R.D., Schwartz, M.W. Diabetes (2002)
- Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Marsh, D.J., Miura, G.I., Yagaloff, K.A., Schwartz, M.W., Barsh, G.S., Palmiter, R.D. Brain Res. (1999)
- Impact of interrupted leptin pathways on ventilatory control. Polotsky, V.Y., Smaldone, M.C., Scharf, M.T., Li, J., Tankersley, C.G., Smith, P.L., Schwartz, A.R., O'Donnell, C.P. J. Appl. Physiol. (2004)
- NPY and Y receptors: lessons from transgenic and knockout models. Lin, S., Boey, D., Herzog, H. Neuropeptides (2004)
- Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice. Karlsson, R.M., Holmes, A., Heilig, M., Crawley, J.N. Pharmacol. Biochem. Behav. (2005)
- Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Jones, K.R., Fariñas, I., Backus, C., Reichardt, L.F. Cell (1994)
- STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Bates, S.H., Stearns, W.H., Dundon, T.A., Schubert, M., Tso, A.W., Wang, Y., Banks, A.S., Lavery, H.J., Haq, A.K., Maratos-Flier, E., Neel, B.G., Schwartz, M.W., Myers, M.G. Nature (2003)
- Gut hormone PYY(3-36) physiologically inhibits food intake. Batterham, R.L., Cowley, M.A., Small, C.J., Herzog, H., Cohen, M.A., Dakin, C.L., Wren, A.M., Brynes, A.E., Low, M.J., Ghatei, M.A., Cone, R.D., Bloom, S.R. Nature (2002)
- Leptin-regulated endocannabinoids are involved in maintaining food intake. Di Marzo, V., Goparaju, S.K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G.I., Palmiter, R.D., Sugiura, T., Kunos, G. Nature (2001)
- Life without neuropeptide Y. Palmiter, R.D., Erickson, J.C., Hollopeter, G., Baraban, S.C., Schwartz, M.W. Recent Prog. Horm. Res. (1998)
- Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Bergen, H.T., Mizuno, T.M., Taylor, J., Mobbs, C.V. Endocrinology (1998)
- Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Sindelar, D.K., Ste Marie, L., Miura, G.I., Palmiter, R.D., McMinn, J.E., Morton, G.J., Schwartz, M.W. Endocrinology (2004)
- Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity. Tu, B., Jiao, Y., Herzog, H., Nadler, J.V. Neuroscience (2006)
- Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice. Imai, Y., Patel, H.R., Hawkins, E.J., Doliba, N.M., Matschinsky, F.M., Ahima, R.S. Endocrinology (2007)
- A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Ishihara, A., Kanatani, A., Mashiko, S., Tanaka, T., Hidaka, M., Gomori, A., Iwaasa, H., Murai, N., Egashira, S., Murai, T., Mitobe, Y., Matsushita, H., Okamoto, O., Sato, N., Jitsuoka, M., Fukuroda, T., Ohe, T., Guan, X., Macneil, D.J., Van der Ploeg, L.H., Nishikibe, M., Ishii, Y., Ihara, M., Fukami, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Shimokawa, T., Kumar, M.V., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Hohmann, J.G., Teklemichael, D.N., Weinshenker, D., Wynick, D., Clifton, D.K., Steiner, R.A. Mol. Cell. Biol. (2004)
- Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Wraith, A., Törnsten, A., Chardon, P., Harbitz, I., Chowdhary, B.P., Andersson, L., Lundin, L.G., Larhammar, D. Genome Res. (2000)
- Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. Korner, J., Savontaus, E., Chua, S.C., Leibel, R.L., Wardlaw, S.L. J. Neuroendocrinol. (2001)
- The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Cowley, M.A., Smith, R.G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K.L., Strasburger, C.J., Bidlingmaier, M., Esterman, M., Heiman, M.L., Garcia-Segura, L.M., Nillni, E.A., Mendez, P., Low, M.J., Sotonyi, P., Friedman, J.M., Liu, H., Pinto, S., Colmers, W.F., Cone, R.D., Horvath, T.L. Neuron (2003)
- Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Cavadas, C., Céfai, D., Rosmaninho-Salgado, J., Vieira-Coelho, M.A., Moura, E., Busso, N., Pedrazzini, T., Grand, D., Rotman, S., Waeber, B., Aubert, J.F., Grouzmann, E. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Raposinho, P.D., Pedrazzini, T., White, R.B., Palmiter, R.D., Aubert, M.L. Endocrinology (2004)
- Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice. Turi, G.F., Liposits, Z., Moenter, S.M., Fekete, C., Hrabovszky, E. Endocrinology (2003)
- Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease. Diez, M., Koistinaho, J., Dearmond, S.J., Groth, D., Prusiner, S.B., Hökfelt, T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Dexamethasone rapidly increases hypothalamic neuropeptide Y secretion in adrenalectomized ob/ob mice. Chen, H.L., Romsos, D.R. Am. J. Physiol. (1996)
- Differential influence of BDNF and NT3 on the expression of calcium binding proteins and neuropeptide Y in vivo. Agerman, K., Ernfors, P. Neuroreport (2003)
- Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro. Buresi, M.C., Vergnolle, N., Sharkey, K.A., Keenan, C.M., Andrade-Gordon, P., Cirino, G., Cirillo, D., Hollenberg, M.D., MacNaughton, W.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide y and corticotropin-releasing hormone. Luque, R.M., Park, S., Kineman, R.D. Endocrinology (2007)
- Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin-releasing hormone secretion in adrenalectomized mice. Jang, M., Mistry, A., Swick, A.G., Romsos, D.R. J. Nutr. (2000)
- Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice. Arens, J., Moar, K.M., Eiden, S., Weide, K., Schmidt, I., Mercer, J.G., Simon, E., Korf, H.W. Physiol. Genomics (2003)
- Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Mantzoros, C.S., Qu, D., Frederich, R.C., Susulic, V.S., Lowell, B.B., Maratos-Flier, E., Flier, J.S. Diabetes (1996)
- Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Kesterson, R.A., Huszar, D., Lynch, C.A., Simerly, R.B., Cone, R.D. Mol. Endocrinol. (1997)
- Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Mizuno, T.M., Mobbs, C.V. Endocrinology (1999)
- Anorexigenic melanocortin signaling in the hypothalamus is augmented in association with failure-to-thrive in a transgenic mouse model for Prader-Willi syndrome. Ge, Y., Ohta, T., Driscoll, D.J., Nicholls, R.D., Kalra, S.P. Brain Res. (2002)
- Reduced hypothalamic neuropeptide Y expression in growth hormone- and prolactin-deficient Ames and Snell dwarf mice. Hurley, D.L., Birch, D.V., Almond, M.C., Estrada, I.J., Phelps, C.J. Endocrinology (2003)
- Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Tritos, N.A., Elmquist, J.K., Mastaitis, J.W., Flier, J.S., Maratos-Flier, E. Endocrinology (1998)