Disease relevance of PUM1

• The highly conserved Pumilio protein family plays crucial roles in fertility of many organisms acting as a repressor of translation, and causing infertility when mutated [1].

Psychiatry related information on PUM1

High impact information on PUM1

• The modular architecture of the Pumilio RNA-binding domain allows the engineering of its RNA sequence specificity [2].
• Previous studies showed that PUF-8, a PUF protein with striking similarity to human Pumilio, prevents return of primary spermatocytes to the mitotic cell cycle [Subramaniam, K. & Seydoux, G. (2003) Curr. Biol. 13, 134-139] [3] .
• Translational repression: a duet of Nanos and Pumilio [4].
• The major downregulated genes are DeltaNp63 and PUMILIO, two potential markers for the maintenance of keratinocyte stem cells [5].

Biological context of PUM1

• PUM1 consists of 22 exons, spanning about 150 kb on chromosome 1p35.2, whereas PUM2 consists of 20 exons and spans at least 80 kb on chromosome 2p23-24 [6].
• Extremely high evolutionary conservation of the RNA-binding domain from yeast to humans, and conserved function of Pumilio proteins in invertebrates and lower vertebrates suggest that mammalian Pumilio proteins could also play an important role in translational regulation of embryogenesis and cell development and differentiation [6].
• Meiosis alone may require several hundred genes, including homologs of the BOULE (BOL) and PUMILIO ( PUM2) gene families [7].
• Proteins with conserved functions in translational control during development include cytoplasmic polyadenylation element binding proteins (CPEB/Orb), Pumilio, Bruno, Fragile X mental retardation protein and RNA helicases [8].
• Molecular genetics of Rhabdomys pumilio subspecies boundaries: mtDNA phylogeography and karyotypic analysis by fluorescence in situ hybridization [9].

Anatomical context of PUM1

• Both BOL and PUM homologs encode germ cell specific RNA binding proteins in diverse organisms where they are required for germ cell development [7].
• We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio [10].
• The mechanism of the twitch potentiating action of pumiliotoxin-B (PTX-B), an indolizidine alkaloid from the skin of the frog Dendrobates pumilio, was studied on frog skeletal muscles [11].
• Microspectrophotometry of isolated rod and cone photoreceptors of D. pumilio revealed the presence of a trichromatic photopic visual system [12].
• Two spotted fever group rickettsia strains, A-108 and A-167, were isolated from the hemolymph of Rhipicephalus pumilio ticks collected in the Astrakhan region of Russia, which is area endemic for Astrakhan fever [13].

Associations of PUM1 with chemical compounds

Other interactions of PUM1

• Here, we demonstrate that human BOL forms homodimers and is able to interact with a PUMILIO homolog, PUM2 [7].
• Sequence analysis of ZAR1 cDNAs evidenced numerous short inverted repeats within the coding sequences and putative Pumilio-binding and embryo-deadenylation elements within the 3'-untranslated regions, indicating the potential regulation ways [14].
• A comparative analysis of Pumilio homology domains, zinc-containing RNA binders, hnRNP K homology domains and RNA recognition motifs is performed in this review [15].

Analytical, diagnostic and therapeutic context of PUM1

• Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins [6].

References