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Gene Review

PUM1  -  pumilio RNA-binding family member 1

Homo sapiens

Synonyms: HSPUM, HsPUM, KIAA0099, PUMH, PUMH1, ...
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Disease relevance of PUM1

  • The highly conserved Pumilio protein family plays crucial roles in fertility of many organisms acting as a repressor of translation, and causing infertility when mutated [1].

Psychiatry related information on PUM1


High impact information on PUM1

  • The modular architecture of the Pumilio RNA-binding domain allows the engineering of its RNA sequence specificity [2].
  • Previous studies showed that PUF-8, a PUF protein with striking similarity to human Pumilio, prevents return of primary spermatocytes to the mitotic cell cycle [Subramaniam, K. & Seydoux, G. (2003) Curr. Biol. 13, 134-139] [3] .
  • Translational repression: a duet of Nanos and Pumilio [4].
  • The major downregulated genes are DeltaNp63 and PUMILIO, two potential markers for the maintenance of keratinocyte stem cells [5].

Biological context of PUM1


Anatomical context of PUM1


Associations of PUM1 with chemical compounds


Other interactions of PUM1

  • Here, we demonstrate that human BOL forms homodimers and is able to interact with a PUMILIO homolog, PUM2 [7].
  • Sequence analysis of ZAR1 cDNAs evidenced numerous short inverted repeats within the coding sequences and putative Pumilio-binding and embryo-deadenylation elements within the 3'-untranslated regions, indicating the potential regulation ways [14].
  • A comparative analysis of Pumilio homology domains, zinc-containing RNA binders, hnRNP K homology domains and RNA recognition motifs is performed in this review [15].

Analytical, diagnostic and therapeutic context of PUM1


  1. Polymorphisms of the human PUMILIO2 gene and male sterility. Kusz, K., Ginter-Matuszewska, B., Ziolkowska, K., Spik, A., Bierla, J., Jedrzejczak, P., Latos-Bielenska, A., Pawelczyk, L., Jaruzelska, J. Mol. Reprod. Dev. (2007) [Pubmed]
  2. Engineering RNA sequence specificity of Pumilio repeats. Cheong, C.G., Hall, T.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. Bachorik, J.L., Kimble, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Translational repression: a duet of Nanos and Pumilio. Parisi, M., Lin, H. Curr. Biol. (2000) [Pubmed]
  5. Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. Dazard, J.E., Gal, H., Amariglio, N., Rechavi, G., Domany, E., Givol, D. Oncogene (2003) [Pubmed]
  6. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. Spassov, D.S., Jurecic, R. Gene (2002) [Pubmed]
  7. Interaction of the conserved meiotic regulators, BOULE (BOL) and PUMILIO-2 (PUM2). Urano, J., Fox, M.S., Reijo Pera, R.A. Mol. Reprod. Dev. (2005) [Pubmed]
  8. Mechanisms of translational control by the 3' UTR in development and differentiation. de Moor, C.H., Meijer, H., Lissenden, S. Semin. Cell Dev. Biol. (2005) [Pubmed]
  9. Molecular genetics of Rhabdomys pumilio subspecies boundaries: mtDNA phylogeography and karyotypic analysis by fluorescence in situ hybridization. Rambau, R.V., Stanyon, R., Robinson, T.J. Mol. Phylogenet. Evol. (2003) [Pubmed]
  10. Vertebrate GLD2 poly(A) polymerases in the germline and the brain. Rouhana, L., Wang, L., Buter, N., Kwak, J.E., Schiltz, C.A., Gonzalez, T., Kelley, A.E., Landry, C.F., Wickens, M. RNA (2005) [Pubmed]
  11. Pharmacology of the alkaloid pumiliotoxin-B. II. Possible involvement of calcium and sodium-dependent processes in nerve and skeletal muscle. Rao, K.S., Warnick, J.E., Daly, J.W., Albuquerque, E.X. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  12. Interspecific and intraspecific views of color signals in the strawberry poison frog Dendrobates pumilio. Siddiqi, A., Cronin, T.W., Loew, E.R., Vorobyev, M., Summers, K. J. Exp. Biol. (2004) [Pubmed]
  13. Astrakhan fever rickettsiae: antigenic and genotypic analysis of isolates obtained from human and Rhipicephalus pumilio ticks. Eremeeva, M.E., Beati, L., Makarova, V.A., Fetisova, N.F., Tarasevich, I.V., Balayeva, N.M., Raoult, D. Am. J. Trop. Med. Hyg. (1994) [Pubmed]
  14. Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells. Uzbekova, S., Roy-Sabau, M., Dalbiès-Tran, R., Perreau, C., Papillier, P., Mompart, F., Thelie, A., Pennetier, S., Cognie, J., Cadoret, V., Royere, D., Monget, P., Mermillod, P. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  15. Sequence-specific binding of single-stranded RNA: is there a code for recognition? Auweter, S.D., Oberstrass, F.C., Allain, F.H. Nucleic Acids Res. (2006) [Pubmed]
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