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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEBI:74112     2-amino-3-hydroxy-pentanoic acid

Synonyms: H4002_SIGMA, CTK8G4340, AKOS009157176, FT-0639152, FT-0694638, ...
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Disease relevance of beta-Hydroxynorvaline


High impact information on beta-Hydroxynorvaline

  • We have shown previously that processing of preprolactin to prolactin in isolated rat pituitaries is inhibited by the threonine analog, beta-hydroxynorvaline (Hnv), presumably because of its substitution for the threonine at the cleavage site [2].
  • Incorporation of the threonine analogue beta-hydroxynorvaline produced species approximately 2.5 kDa and approximately 5 kDa smaller than the fully glycosylated pro-MPO, suggesting that two of the glycans were in the asparagine-X-threonine tripeptide sequence [3].
  • Both the capacity to undergo autolytic cleavage and the Mr increase were inhibited by cell culture in the presence of the antibiotic tunicamycin or the threonine analog beta-hydroxynorvaline, both of which inhibit glycosylation [4].
  • The amino acid side chain was characterized as 3-hydroxynorvaline (3) by gas chromatography-mass spectrometry of the trimethylsilyl derivative after cleavage from 1 and 2 by alkaline hydrolysis [5].
  • Treatment of HSV-infected cells with 5-10 mM beta-hydroxynorvaline (Hnv), a threonine analog, specifically affects herpesvirus DNA replication: both the rate of and total DNA synthesis are reduced, the former approximately 15-fold by Hnv (6 h post-infection) and the latter by 12-fold (between 3 and 12 h post-infection) [6].

Biological context of beta-Hydroxynorvaline


Anatomical context of beta-Hydroxynorvaline


Gene context of beta-Hydroxynorvaline


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