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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1LCVGZ     7-[(1R,4R,6R,9S)-4-(1,1- difluoropentyl)-4...

Synonyms: S1675_Selleck, SureCN454016, CHEMBL1201134, SPI0211, AC-1863, ...
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Disease relevance of Lubiprostone

  • Significantly greater improvements occurred with lubiprostone than placebo in the degree of straining, stool consistency and constipation severity (where reported) in both pivotal studies (p < 0.05 for all comparisons at all timepoints) [1].

High impact information on Lubiprostone


Chemical compound and disease context of Lubiprostone

  • Use of tegaserod and the recently approved lubiprostone is supported by high-quality evidence, and these agents have acceptable safety profiles in patients with chronic constipation [3].

Anatomical context of Lubiprostone


Gene context of Lubiprostone

  • Our aim was to compare the effects of the selective ClC-2 activator lubiprostone on maximum tolerated volume (MTV) of a meal, postprandial symptoms, gastric volumes, and gastrointestinal and colonic transit in humans [2].

Analytical, diagnostic and therapeutic context of Lubiprostone


  1. Lubiprostone. McKeage, K., Plosker, G.L., Siddiqui, M.A. Drugs (2006) [Pubmed]
  2. Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Camilleri, M., Bharucha, A.E., Ueno, R., Burton, D., Thomforde, G.M., Baxter, K., McKinzie, S., Zinsmeister, A.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  3. Treating chronic constipation : How should we interpret the recommendations? Johnson, D.A. Clinical drug investigation (2006) [Pubmed]
  4. Activation of type-2 chloride channels: a novel therapeutic target for the treatment of chronic constipation. Crowell, M.D., Harris, L.A., DiBaise, J.K., Olden, K.W. Current opinion in investigational drugs (London, England : 2000) (2007) [Pubmed]
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