Disease relevance of CM 7857

• Evaluation of pentisomide on stable ventricular premature beats. Comparison with placebo [1].
• When pentisomide was infused at 1 mg/kg/min for 20 min, the ventricular tachycardia was significantly reduced at 5 min after starting the infusion; the arrhythmias were reduced to less than 5% at the end of the 20 min infusion [2].
• In conclusion, pentisomide inhibits arrhythmias dependent with the plasma concentration or with the concentration of the external solution [2].
• If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either [3].
• Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia [3].

High impact information on CM 7857

• Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857) [4].
• In guinea pig left atria, disopyramide, pirmenol and pentisomide shifted the concentration-response curves for the negative inotropic effect of carbachol in a parallel manner [5].
• Computer-assisted analysis indicated that pirmenol interacted with a single class of binding sites, but the displacement curves of disopyramide and pentisomide were shallow and best fitted to a two-site model [5].
• Protein binding of propisomide [6].
• The major metabolite of the drug or other drugs with affinity for alpha1-acid glycoprotein can displace propisomide from its binding site only when present in serum at high levels [6].

Biological context of CM 7857

• The electrophysiological effects of pentisomide upon the intact human heart were evaluated using programmed stimulation and recording of intracardiac monophasic action potentials (MAP) in 17 patients with various ventricular arrhythmias [7].
• Mean AUC was larger and terminal elimination half-life longer in the elderly subjects, due to a decrease in total plasma clearance of pentisomide in the elderly [8].

Anatomical context of CM 7857

• Electrophysiological studies of penticainide (CM 7857), a new antiarrhythmic agent, in mammalian myocardium [9].
• Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle and the atrioventricular node [3].

Analytical, diagnostic and therapeutic context of CM 7857

• Results are similar to those by gas chromatography for propisomide but, in addition, the metabolite can be simultaneously measured in the same clinical sample [10].
• Two ultrafiltration techniques are compared to equilibrium dialysis for the determination of serum protein binding of propisomide [6].
• Quantitation of pentisomide and its metabolite by high-pressure liquid chromatography in human serum [11].

References