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Chemical Compound Review

disopyramide     4-(dipropan-2-ylamino)-2- phenyl-2-pyridin...

Synonyms: Isorythm, Ritmodan, Lispine, Rythmodan, Dicorantil, ...
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Disease relevance of disopyramide


Psychiatry related information on disopyramide

  • Serendipitous relief with disopyramide of phobia for flying [6].
  • The peak response (change in pre-ejection period) and area under the response time curves were better related to free than to total serum concentrations of disopyramide [7].
  • Improved patient compliance as regards dosing, ease in stabilizing blood levels of disopyramide, and effective antiarrhythmic control has been a significant factor in physician satisfaction with this preparation [8].

High impact information on disopyramide


Chemical compound and disease context of disopyramide


Biological context of disopyramide


Anatomical context of disopyramide


Associations of disopyramide with other chemical compounds


Gene context of disopyramide

  • Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans [34].
  • Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide [35].
  • Pretreatment of cells with 200 ng/ml pertussis toxin for 3 h, or incubation with the ATP-sensitive K+ channel blocker disopyramide (200 microM), prevented the inhibition by galanin of bombesin- and GIP-stimulated GLP-1 secretion [36].
  • These observations suggest that disopyramide directly blocks the pore-forming Kir6.2 subunit, in particular at reduced intracellular pH values that occur under cardiac ischaemia [37].
  • Relief of clinical symptoms in hypertrophic obstructive cardiomyopathy with disopyramide might be due in part to improvement of diastolic function, which appears secondary to the reduction in ventricular afterload [38].

Analytical, diagnostic and therapeutic context of disopyramide


  1. Cardiac arrhythmias associated with disopyramide. Kinney, E.L., Field, E.H., Salmon, M.P., Zelis, R. N. Engl. J. Med. (1980) [Pubmed]
  2. Congestive heart failure caused by oral disopyramide. Podrid, P.J., Schoeneberger, A., Lown, B. N. Engl. J. Med. (1980) [Pubmed]
  3. Muscular subaortic stenosis: hemodynamic and clinical improvement after disopyramide. Pollick, C. N. Engl. J. Med. (1982) [Pubmed]
  4. Fasting hypoglycemia secondary to disopyramide therapy. Report of two cases. Quevedo, S.F., Krauss, D.S., Chazan, J.A., Crisafulli, F.S., Kahn, C.B. JAMA (1981) [Pubmed]
  5. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. Bou-Holaigah, I., Rowe, P.C., Kan, J., Calkins, H. JAMA (1995) [Pubmed]
  6. Serendipitous relief with disopyramide of phobia for flying. Lewis, D.O. The American journal of psychiatry. (1983) [Pubmed]
  7. Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics. Lima, J.J., Boudoulas, H., Blanford, M. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  8. Long-term use of controlled-release disopyramide in patients with severe ventricular arrhythmias. Paulk, E.A. Angiology. (1987) [Pubmed]
  9. Initiation of uterine contractions by disopyramide during pregnancy. Leonard, R.F., Braun, T.E., Levy, A.M. N. Engl. J. Med. (1978) [Pubmed]
  10. Cardiogenic shock associated with disopyramide phosphate. Sinatra, S.T., Landry, A.B., Galle, J.S., Amato, J. JAMA (1980) [Pubmed]
  11. Agranulocytosis associated with disopyramide therapy. Conrad, M.E., Cumbie, W.G., Thrasher, D.R., Carpenter, J.T. JAMA (1978) [Pubmed]
  12. Relative efficacy and safety of intravenous drugs for termination of sustained ventricular tachycardia. Griffith, M.J., Linker, N.J., Garratt, C.J., Ward, D.E., Camm, A.J. Lancet (1990) [Pubmed]
  13. Intravenous and oral disopyramide after myocardial infarction. Nicholls, D.P., Haybyrne, T., Barnes, P.C. Lancet (1980) [Pubmed]
  14. Randomised placebo-controlled trial comparing oxprenolol with disopyramide phosphate in immediate treatment of suspected myocardial infarction. Wilcox, R.G., Rowley, J.M., Hampton, J.R., Mitchell, J.R., Roland, J.M., Banks, D.C. Lancet (1980) [Pubmed]
  15. Idiopathic ventricular fibrillation: inducibility and beneficial effects of class I antiarrhythmic agents. Belhassen, B., Shapira, I., Shoshani, D., Paredes, A., Miller, H., Laniado, S. Circulation (1987) [Pubmed]
  16. Relative role of alkalosis and sodium ions in reversal of class I antiarrhythmic drug-induced sodium channel blockade by sodium bicarbonate. Bou-Abboud, E., Nattel, S. Circulation (1996) [Pubmed]
  17. Disopyramide (Norpace)-induced hypoglycemia. Goldberg, I.J., Brown, L.K., Rayfield, E.J. Am. J. Med. (1980) [Pubmed]
  18. Role of anisotropy in determining the selective action of antiarrhythmics in atrial flutter in the dog. Yamashita, T., Inoue, H., Nozaki, A., Kuo, T.T., Usui, M., Sugimoto, T. Cardiovasc. Res. (1992) [Pubmed]
  19. Adverse hemodynamic effects of intravenous disopyramide compared with quinidine in conscious dogs. Walsh, R.A., Horwitz, L.D. Circulation (1979) [Pubmed]
  20. Electrophysiological effects of the optical isomers of disopyramide and quinidine in the dog. Dependence on stereochemistry. Mirro, M.J., Watanabe, A.M., Bailey, J.C. Circ. Res. (1981) [Pubmed]
  21. Two components of use-dependent block of Na+ current by disopyramide and lidocaine in guinea pig ventricular myocytes. Sunami, A., Fan, Z., Nitta, J., Hiraoka, M. Circ. Res. (1991) [Pubmed]
  22. High- and low-affinity sites for [3H]dofetilide binding to guinea pig myocytes. Duff, H.J., Feng, Z.P., Sheldon, R.S. Circ. Res. (1995) [Pubmed]
  23. Double-blind crossover randomized trial of intravenously administered verapamil. Its use for atrial fibrillation and flutter following open heart surgery. Hwang, M.H., Danoviz, J., Pacold, I., Rad, N., Loeb, H.S., Gunnar, R.M. Arch. Intern. Med. (1984) [Pubmed]
  24. Disopyramide. Morady, F., Scheinman, M.M., Desai, J. Ann. Intern. Med. (1982) [Pubmed]
  25. Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current. Tachibana, H., Yamaki, M., Kubota, I., Watanabe, T., Yamauchi, S., Tomoike, H. Circulation (1999) [Pubmed]
  26. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Pollick, C., Giacomini, K.M., Blaschke, T.F., Nelson, W.L., Turner-Tamiyasu, K., Briskin, V., Popp, R.L. Circulation (1982) [Pubmed]
  27. The direct electrophysiologic effects of disopyramide phosphate in the transplanted human heart. Bexton, R.S., Hellestrand, K.J., Cory-Pearce, R., Spurrell, R.A., English, T.A., Camm, A.J. Circulation (1983) [Pubmed]
  28. Activation block and trapping of penticainide, a disopyramide analogue, in the Na+ channel of rabbit cardiac Purkinje fibers. Carmeliet, E. Circ. Res. (1988) [Pubmed]
  29. The effect of concurrent oral administration of propranolol and disopyramide on cardiac function in healthy men. Cathcart-Rake, W.F., Coker, J.E., Atkins, F.L., Huffman, D.H., Hassanein, K.M., Shen, D.D., Azarnoff, D.L. Circulation (1980) [Pubmed]
  30. Electrophysiological effects of disopyramide in patients with bundle branch block. Desai, J.M., Scheinman, M., Peters, R.W., O'Young, J. Circulation (1979) [Pubmed]
  31. Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design. Pratt, C.M., Young, J.B., Francis, M.J., Taylor, A.A., Norton, H.J., English, L., Mann, D.E., Kopelen, H., Quinones, M.A., Roberts, R. Circulation (1984) [Pubmed]
  32. ATP-sensitive K+ channels mediate alpha 2D-adrenergic receptor contraction of arteriolar smooth muscle and reversal of contraction by hypoxia. Tateishi, J., Faber, J.E. Circ. Res. (1995) [Pubmed]
  33. Combination of disopyramide and mexiletine for better tolerance and additive effects for treatment of ventricular arrhythmias. Kim, S.G., Mercando, A.D., Tam, S., Fisher, J.D. J. Am. Coll. Cardiol. (1989) [Pubmed]
  34. Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Echizen, H., Tanizaki, M., Tatsuno, J., Chiba, K., Berwick, T., Tani, M., Gonzalez, F.J., Ishizaki, T. Drug Metab. Dispos. (2000) [Pubmed]
  35. Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Zhang, L., Fitzloff, J.F., Engel, L.C., Cook, C.S. Xenobiotica (2001) [Pubmed]
  36. Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells. Saïfia, S., Chevrier, A.M., Bosshard, A., Cuber, J.C., Chayvialle, J.A., Abello, J. J. Endocrinol. (1998) [Pubmed]
  37. Disopyramide block of K(ATP) channels is mediated by the pore-forming subunit. Zünkler, B.J., Kühne, S., Rustenbeck, I., Ott, T., Hildebrandt, A.G. Life Sci. (2000) [Pubmed]
  38. Salutary effect of disopyramide on left ventricular diastolic function in hypertrophic obstructive cardiomyopathy. Matsubara, H., Nakatani, S., Nagata, S., Ishikura, F., Katagiri, Y., Ohe, T., Miyatake, K. J. Am. Coll. Cardiol. (1995) [Pubmed]
  39. Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards. Zainal, N., Carmichael, D.J., Griffiths, J.W., Besterman, E.M., Kidner, P.H., Gillham, A.D., Summers, G.D. Lancet (1977) [Pubmed]
  40. Effects of oral disopyramide phosphate on induction and sustenance of atrioventricular reentrant tachycardia incorporating retrograde accessory pathway conduction. Kou, H.C., Hung, J.S., Lee, Y.S., Wu, D. Circulation (1982) [Pubmed]
  41. The cellular electrophysiologic mechanism of the dual actions of disopyramide on rabbit sinus node function. Katoh, T., Karagueuzian, H.S., Jordan, J., Mandel, W.J. Circulation (1982) [Pubmed]
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