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Chemical Compound Review

SureCN77988     1-[3-[2-(2- diethylaminoethoxy) phenyl]pheny...

Synonyms: AG-K-20424, CTK6E8528, AC1L25V8
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Disease relevance of Etafenone


High impact information on Etafenone

  • Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses [2].
  • It was suggested that the better recovery of myocardial high energy phosphate levels produced by etafenone was brought about by a decrease in oxygen consumption due to a decrease in mechanical performance of the heart and possibly by a better resynthesis of ATP [2].
  • In both atrial and ventricular fibers, etafenone prolonged the action potential duration and total refractory period [3].
  • The correlation of ultrastructural, ultracytochemical and X-ray microanalytical findings provides direct evidence of the hypothesis that etafenone acts on myocardium as a so-called "calcium antagonist". The subcellular targets of etafenone action are mainly the sarcoplasmic reticulum and mitochondria [1].
  • The distribution of blood flow to the subendocardial, medium and subepicardial layers of the left ventricular free wall was studied in anaesthetized dogs under normoxic (A), hypoxic (B) conditions and under pharmacologically induced (etafenone) coronary vasodilation (C) [4].

Anatomical context of Etafenone


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